Microbead dynamics on quartz crystal microbalance at elevated amplitudes

The application of the Quartz Crystal Microbalance (QCM) for biochemical sensing is well known. However, utilizing the nonlinear response of the QCM at elevated amplitudes has received sporadic attention. This study presents results for QCM-analyte interaction that provide insight into the nonlinear dynamics of the QCM with attached analyte. In particular, interactions of the QCM with polystyrene microbeads physisorbed via self-assembled monolayer (SAM) were studied through experiments and modelling. It was found that the response of the QCM coupled to these surface adsorbents is anharmonic even at low oscillation amplitudes and that the nonlinear signals from such interactions are much higher than those for bare quartz. Therefore, these signals can potentially be used as sensitive signatures of adsorbents and their kinetics on the surface. ©2009 IEEE.