Industry perceptions of barriers to commercialization of regenerative medicine products in the UK.

AIMS: Regenerative medicine is an emerging field with the potential to provide widespread improvement in healthcare and patient wellbeing via the delivery of therapies that can restore, regenerate or repair damaged tissue. As an industry, it could significantly contribute to economic growth if products are successfully commercialized. However, to date, relatively few products have reached the market owing to a variety of barriers, including a lack of funding and regulatory hurdles. The present study analyzes industry perceptions of the barriers to commercialization that currently impede the success of the regenerative medicine industry in the UK. MATERIALS & METHODS: The analysis is based on 20 interviews with leading industrialists in the field. RESULTS: The study revealed that scientific research in regenerative medicine is thriving in the UK. Unfortunately, lack of access to capital, regulatory hurdles, lack of clinical evidence leading to problems with reimbursement, as well as the culture of the NHS do not provide a good environment for the commercialization of regenerative medicine products. CONCLUSION: Policy interventions, including increased translational government funding, a change in NHS and NICE organization and policies, and regulatory clarity, would likely improve the general outcomes for the regenerative medicine industry in the UK.

Analysis and performance assessment of 6-pulse inverter-fed 3-phase and 6-phase induction machines

The paper describes a model for a 6-phase induction motor driven by an inverter operating in a 6-pulse (square wave) mode. The model is implemented and performance, in terms of torque, current, efficiency and pulsating torque, compared to the performance of a 3-phase motor (both sine and 6-pulse supplied). The models are verified experimentally, in particular the efficiency performance, and it is illustrated that the improvement in inverter efficiency when in 6-pulse operating mode may improve the performance of the overall system. © 2005 IEEE.

Numerical back-analysis of energy pile test at Lambeth College, London

Energy Piles present an efficient solution for long-term carbon emission reduction and sustainable construction. However, they have received only partial acceptance by the industry, because of concerns regarding the impact of cyclic thermal changes on the serviceability of energy pile foundations. This paper investigates the applicability of the hybrid load transfer approach to load-settlement analysis of single piles behavior during thermal energy exchange processes. Back-analysis results in terms of the thermal and mechanical response of energy piles show good agreement with field test results from Lambeth College in London. © ASCE 2011.

Simplifying mooring analysis for deepwater systems using truncation

Over recent years academia and industry have engaged with the challenge of model testing deepwater structures at conventional scales. One approach to the limited depth problem has been to truncate the lines. This concept will be introduced, highlighting the need to better understand line dynamic processes. The type of line truncation developed here models the upper sections of each line in detail, capturing wave action and all coupling effects with the vessel, terminating to an approximate analytical model that aims to simulate the remainder of the line. A rationale for this is that in deep water transverse elastic waves of a line are likely to decay before they are reflected at the seabed because of nonlinear hydrodynamic drag forces. The first part of this paper is centered on verification of this rationale. A simplified model of a mooring line that describes the transverse dynamics in wave frequency is used, adopting the equation of motion of an inextensible taut string. The line is submerged in still water, one end fixed at the bottom the other assumed to follow the vessel response, which can be harmonic or random. A dimensional analysis, supported by exact benchmark numerical solutions, has shown that it is possible to produce a universal curve for the decay of transverse vibrations along the line, which is suitable for any kind of line with any top motion. This has a significant engineering benefit, allowing for a rapid assessment of line dynamics - it can be useful in deciding whether a truncated line model is appropriate, and if so, at which point truncation might be applied. This is followed by developing a truncation mechanism, formulating an end approximation that can reproduce the correct impedance, had the line been continuous to full depth. It has been found that below a certain length criterion, which is also universal, the transverse vibrational characteristics for each line are inertia driven. As such the truncated model can assume a linear damper whose coefficient depends on the line properties and frequency of vibration. Copyright © 2011 by the International Society of Offshore and Polar Engineers (ISOPE).

A novel method for rapid comparative quantitative analysis of nuclear fuel cycles

One of the greatest obstacles facing the nuclear industry is that of sustainability, both in terms of the finite reserves of uranium ore and the production of highly radiotoxic spent fuel which presents proliferation and environmental hazards. Alternative nuclear technologies have been suggested as a means of delivering enhanced sustainability with proposals including fast reactors, the use of thorium fuel and tiered fuel cycles. The debate as to which is the most appropriate technology continues, with each fuel system and reactor type delivering specific advantages and disadvantages which can be difficult to compare fairly. This paper demonstrates a framework of performance metrics which, coupled with a first-order lumped reactor model to determine nuclide population balances, can be used to quantify the aforementioned pros and cons for a range of different fuel and reactor combinations. The framework includes metrics such as fuel efficiency, spent fuel toxicity and proliferation resistance, and relative cycle performance is analysed through parallel coordinate plots, yielding a quantitative comparison of disparate cycles. © 2011 Elsevier Ltd. All rights reserved.

Change propagation analysis in complex technical systems

Understanding how and why changes propagate during engineering design is critical because most products and systems emerge from predecessors and not through clean sheet design. This paper applies change propagation analysis methods and extends prior reasoning through examination of a large data set from industry including 41,500 change requests, spanning 8 years during the design of a complex sensor system. Different methods are used to analyze the data and the results are compared to each other and evaluated in the context of previous findings. In particular the networks of connected parent, child and sibling changes are resolved over time and mapped to 46 subsystem areas. A normalized change propagation index (CPI) is then developed, showing the relative strength of each area on the absorber-multiplier spectrum between -1 and +1. Multipliers send out more changes than they receive and are good candidates for more focused change management. Another interesting finding is the quantitative confirmation of the "ripple" change pattern. Unlike the earlier prediction, however, it was found that the peak of cyclical change activity occurred late in the program driven by systems integration and functional testing. Patterns emerged from the data and offer clear implications for technical change management approaches in system design. Copyright © 2007 by ASME.

Numerical analysis of thermally actuated magnets for magnetization of superconductors

Superconductors, such as YBCO bulks, have extremely high potential magnetic flux densities, comparing to rare earth magnets. Therefore, the magnetization of superconductors has attracted broad attention and contribution from both academic research and industry. In this paper, a novel technique is proposed to magnetize superconductors. Unusually, instead of using high magnetic fields and pulses, repeatedly magnetic waves with strength of as low as rare earth magnets are applied. These magnetic waves, generated by thermally controlling a Gadolinium (Gd) bulk with a rare earth magnet underneath, travel over the flat surface of a YBCO bulk and get trapped little by little. Thus, a very small magnetic field can be used to build up a very large magnetic field. In this paper, the modelling results of thermally actuated magnetic waves are presented showing how to transfer sequentially applied thermal pulses into magnetic waves. The experiment results of the magnetization of YBCO bulk are also presented to demonstrate how superconductors are progressively magnetized by small magnetic field © 2010 IOP Publishing Ltd.