Contingency awareness in human aversive conditioning involves the middle frontal gyrus.

In contrast to the wealth of data describing the neural mechanisms underlying classical conditioning, we know remarkably little about the mechanisms involved in acquisition of explicit contingency awareness. Subjects variably acquire contingency awareness in classical conditioning paradigms, in which they are able to describe the temporal relationship between a conditioned cue and its outcome. Previous studies have implicated the hippocampus and prefrontal cortex in the acquisition of explicit knowledge, although their specific roles remain unclear. We used functional magnetic resonance imaging to track the trial-by-trial acquisition of explicit knowledge in a concurrent trace and delay conditioning paradigm. We show that activity in bilateral middle frontal gyrus and parahippocampal gyrus correlates with the accuracy of explicit contingency awareness on each trial. In contrast, amygdala activation correlates with conditioned responses indexed by skin conductance responses (SCRs). These results demonstrate that brain regions known to be involved in other aspects of learning and memory also play a specific role, reflecting on each trial the acquisition and representation of contingency awareness.

Performance evaluation of multiplexed model predictive control for a large airliner in nominal and contingency scenarios

Model predictive control allows systematic handling of physical and operational constraints through the use of constrained optimisation. It has also been shown to successfully exploit plant redundancy to maintain a level of control in scenarios when faults are present. Unfortunately, the computational complexity of each individual iteration of the algorithm to solve the optimisation problem scales cubically with the number of plant inputs, so the computational demands are high for large MIMO plants. Multiplexed MPC only calculates changes in a subset of the plant inputs at each sampling instant, thus reducing the complexity of the optimisation. This paper demonstrates the application of multiplexed model predictive control to a large transport airliner in a nominal and a contingency scenario. The performance is compared to that obtained with a conventional synchronous model predictive controller, designed using an equivalent cost function. © 2012 AACC American Automatic Control Council).