Design-phase-specific selection of user research methods

For increasing the usability of a medical device the usability engineering standards IEC 60601-1-6 and IEC 62366 suggest incorporating user information in the design and development process. However, practice shows that integrating user information and the related investigation of users, called user research, is difficult in the field of medical devices. In particular, identifying the most appropriate user research methods is a difficult process. This difficulty results from the complexity of the medical device industry, especially with respect to regulations and standards, the characteristics of this market and the broad range of potential user research methods available from various research disciplines. Against this background, this study aimed at guiding designers and engineers in selecting effective user research methods according to their stage in the design process. Two approaches are described which reduce the complexity of method selection by summarizing the high number of methods into homogenous method classes. These approaches are closely connected to the medical device industry characteristic design phases and therefore provide the possibility of selecting design-phase- specific user research methods. In the first approach potential user research methods are classified after their characteristics in the design process. The second approach suggests a method summarization according to their similarity in the data collection techniques and provides an additional linkage to design phase characteristics. Both approaches have been tested in practice and the results show that both approaches facilitate user research method selection. © 2009 Springer-Verlag.

Corpus design for a unit selection TtS system with application to Bulgarian

In this paper we present the process of designing an efficient speech corpus for the first unit selection speech synthesis system for Bulgarian, along with some significant preliminary results regarding the quality of the resulted system. As the initial corpus is a crucial factor for the quality delivered by the Text-to-Speech system, special effort has been given in designing a complete and efficient corpus for use in a unit selection TTS system. The targeted domain of the TTS system and hence that of the corpus is the news reports, and although it is a restricted one, it is characterized by an unlimited vocabulary. The paper focuses on issues regarding the design of an optimal corpus for such a framework and the ideas on which our approach was based on. A novel multi-stage approach is presented, with special attention given to language and speaker dependent issues, as they affect the entire process. The paper concludes with the presentation of our results and the evaluation experiments, which provide clear evidence of the quality level achieved. © 2011 Springer-Verlag.

FY is an RNA 3' end-processing factor that interacts with FCA to control the Arabidopsis floral transition

The nuclear RNA binding protein, FCA, promotes Arabidopsis reproductive development. FCA contains a WW protein interaction domain that is essential for FCA function. We have identified FY as a protein partner for this domain. FY belongs to a highly conserved group of eukaryotic proteins represented in Saccharomyces cerevisiae by the RNA 3' end-processing factor, Pfs2p. FY regulates RNA 3' end processing in Arabidopsis as evidenced through its role in FCA regulation. FCA expression is autoregulated through the use of different polyadenylation sites within the FCA pre-mRNA, and the FCA/FY interaction is required for efficient selection of the promoter-proximal polyadenylation site. The FCA/FY interaction is also required for the downregulation of the floral repressor FLC. We propose that FCA controls 3' end formation of specific transcripts and that in higher eukaryotes, proteins homologous to FY may have evolved as sites of association for regulators of RNA 3' end processing.

Computer-based selection of joining processes

The assembly of any manufactured product involves joining. This paper describes ways of selecting processes for joining. The method allows discrimination of the joint geometry, joint loading, material, and other attributes of the joint itself, identifying the subset of available processes capable of meeting a given set of design constraints. A relational database containing data-tables for joining processes, materials to be joined, and joint geometry and mode of loading, allows the attributes of each of these to be stored in an appropriate format, and permits links to be created between those that are related. A search engine isolates the processes that meet design requirements on material, joint geometry and loading. The method is illustrated in Part 2 by case studies, utilising software that embodies the method.

Design and process selection for joints in flexible materials

The application of high performance textiles has grown significantly in the last 10 to 15 years. Various research groups throughout the United Kingdom, such as the Department of Trade and Industry, have identified technical textiles as a field for future development. There is little design guidance for joining of flexible materials or general property models that can be applied to theses materials. This lack is due to the large diversity of properties, structures and resulting behaviours of the materials that are classified as "Flexible Materials". This dissertation explores the issues that are involved in characterising the materials at the fibre, bulk and textile levels. Different units of measurement are used for each stage of the manufacturing process of flexible materials and this disparity creates problems when trying to make general comparisons (e.g. comparing textiles to polymer films). Thus, a possible solution to this is to create selection charts that allow designers to compare the strength of materials for a given mass per unit area. A design tool was created using the Cambridge Engineering Selector (CES) software to enable the selection of joining processes for material. The tool is effective in selecting a reduced number of viable joining processes. Through case studies it was shown that designers are required to examine the selected processes (identified by the software) in greater detail - in particular the economics and geometry of the joint - in order to identify the optimum joining process.