Modelling rail corrugation with specific track parameters focusing on ballasted track and slab track

The objective of this paper is to compare 3 types of track (high performance ballasted track, STEDEF and AFTRAV) from the corrugation growth point of view. This work has considered different vehicle speeds and track radii, and the results have taken into account the four wheels of a bogie. These tracks have been studied using Finite Elements with Nastran-Patran and RACING, a tool developed in Matlab by the authors which estimates the corrugation growth tendency. The tracks are studied using the Finite Strip Method and the Periodic Structure Theory. Lateral and vertical receptances for track and vehicle have been obtained, as well as the corrugation growth functions. In the paper the tracks are ranked according to corrugation development.

Euskal testu corpusa osatzen: J.P. Ulibarriren "Egunare eusquerazcoa erderascotic itzuliya"

[EUS] Artikulu honetan J. P. Ulibarri idazle okondoarrak 1815an argitaratu zuen "Egunare euskerazkoa erdaraskotik itzuliya" egutegia aurkezten dugu, urteetan galdutzat jo izan dena. Lan honetan, orain arte euskal bibliografoek "Egunare"-az esan dutena laburtu dugu (§1), eta horrekin batera alearen deskribapena eskaini dugu bai fisikoa eta baita gaien arabera(§2). Hirugarren atalean(§3), libarriren egiletasuna bermatu dugu: testua egile izenik gabe argitaratu bazen ere albaitariaren lantzat jo dugu, bere idaztankera eta euskara moldea aztertzeko lan honek duen garrantzia azpimarratuz. Amaitzeko, testua bera eskaini dugu, bai edizio erdipaleografiko legez eta baita faksimile eran.

Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene

Age of onset (AO) of Huntington disease (HD) is mainly determined by the length of the CAG repeat expansion (CAGexp) in exon 1 of the HTT gene. Additional genetic variation has been suggested to contribute to AO, although the mechanism by which it could affect AO is presently unknown. The aim of this study is to explore the contribution of candidate genetic factors to HD AO in order to gain insight into the pathogenic mechanisms underlying this disorder. For that purpose, two AO definitions were used: the earliest age with unequivocal signs of HD (earliest AO or eAO), and the first motor symptoms age (motor AO or mAO). Multiple linear regression analyses were performed between genetic variation within 20 candidate genes and eAO or mAO, using DNA and clinical information of 253 HD patients from REGISTRY project. Gene expression analyses were carried out by RT-qPCR with an independent sample of 35 HD patients from Basque Country Hospitals. We found suggestive association signals between HD eAO and/or mAO and genetic variation within the E2F2, ATF7IP, GRIN2A, GRIN2B, LINC01559, HIP1 and GRIK2 genes. Among them, the most significant was the association between eAO and rs2742976, mapping to the promoter region of E2F2 transcription factor. Furthermore, rs2742976 T allele patient carriers exhibited significantly lower lymphocyte E2F2 gene expression, suggesting a possible implication of E2F2-dependent transcriptional activity in HD pathogenesis. Thus, E2F2 emerges as a new potential HD AO modifier factor.