Prioritization of candidate cancer genes-an aid to oncogenomic studies

The development of techniques for oncogenomic analyses such as array comparative genomic hybridization, messenger RNA expression arrays and mutational screens have come to the fore in modern cancer research. Studies utilizing these techniques are able to highlight panels of genes that are altered in cancer. However, these candidate cancer genes must then be scrutinized to reveal whether they contribute to oncogenesis or are coincidental and non-causative. We present a computational method for the prioritization of candidate (i) proto-oncogenes and (ii) tumour suppressor genes from oncogenomic experiments. We constructed computational classifiers using different combinations of sequence and functional data including sequence conservation, protein domains and interactions, and regulatory data. We found that these classifiers are able to distinguish between known cancer genes and other human genes. Furthermore, the classifiers also discriminate candidate cancer genes from a recent mutational screen from other human genes. We provide a web-based facility through which cancer biologists may access our results and we propose computational cancer gene classification as a useful method of prioritizing candidate cancer genes identified in oncogenomic studies.

Bertso eguna 2016: bertso-ikuskizuna eta genero-ikuspegia

[EUS] Gradu Amaierako Lan honetan esparru hauek uztartu dira: bertsolaritza, hedabideak eta Genero Ikasketak. Hiru esparru horien bidegurutzean, 2016ko Bertso Egunaren genero-irakurketa bat egitea du helburu ikerlanak. Genero-azterketa egiteko, bertso-emanaldiaren hiru alderdi nagusi aztertu dira: batetik, antolakuntzak hartutako erabakiak aztertu dira; bestetik, bertsolarien bertso-jardunaren inguruko gogoeta egin da; eta azkenik, EITBk eginiko ikus-entzunezko ekoizpena izan da hizpide. Alderdi horien analisia egiteko lau urrats nagusi egin dira: lehenik, Bertso Egunaren inguruko dokumentazio-lana osatu da; bigarrenik, bertso-egoeren, bertso-jardunaren, eta ikus-entzunezkoaren deskripzioa egin da; hirugarrenik, deskripzioan xehaturiko ezaugarrien interpretazioa egin da, atalez atal; eta laugarrenik, atal guztien ezaugarriak kontuan harturik, ondorio orokor zenbait garatu dira.

Enfoques de estudio y modelos de investigación sobre calidad y resultados: una revisión crítica

[ES] El presente estudio sintetiza las contribuciones realizadas en la investigación sobre la calidad y su relación con los resultados. La revisión se lleva a cabo considerando la variada casuística que se ha utilizado en el diseño de los trabajos analizados, desde distintas medidas para reflejar la gestión de la calidad o los resultados conseguidos por la empresa, hasta el diferente modelo de investigación propuesto. Centrando nuestra atención en los estudios sobre las relaciones entre TQM y resultado financiero, consideramos que el diseño de modelos de análisis que incorporen y combinen tanto medidas subjetivas como objetivas del rendimiento empresarial, ayudaría a entender la diversidad de resultados obtenidos en esta línea de investigación.

European Newspapers’ Digital Transition: New Products and New Audiences

The adaptation of traditional newspapers to new digital media and its interface, far from being a mere technical transformation, has contributed to a gradual change in the media themselves and their audiences. With a sample including the top general information pay newspaper in each of the 28 countries of the European Union, this research has carried out an analysis using 17 indicators divided in 4 categories. The aim is to identify the transformations that the implementation of digital media have brought to the top European newspapers. In general terms, the results show that most dailies have managed to keep their leadership also in online environment. Moreover, an emerging group of global media is growing up, based in preexisting national media. Digital and mobile media have contributed to the appearance of new consumption habits as well, where users read more superficially and sporadically. The audience uses several formats at a time, and digital devices already bring the biggest amount of users to many media. The Internet-created new information windows –search engines, social networks, etc. –are also contributing to the change in professional work routines.