Diseño y puesta en practica de una intervención psicoeducativa en relación al logro de un autoconcepto ajustado.

El autoconcepto es una pieza esencial para el desarrollo adecuado del individuo, por lo que en este trabajo se elabora y aplica una intervención en relación al logro de un autoconcepto ajustado. Para ello, se llevan a cabo una serie de dinámicas en un grupo-clase y periodo de tiempo específicos. Asimismo, se utilizan una serie de instrumentos de medida previa y posteriormente a la intervención, con el objetivo de evaluar las posibles variaciones en lo que al autoconcepto de los alumnos respecta. Finalmente, se concluyen ciertas variaciones que más que reflejar grandes cambios en el autoconcepto del alumnado, indican la importancia y posible eficacia de programas que dirigen su atención a dicho constructo

Towards a Comprehensive Approach to Quantifying and Mapping Ecosystem Services Flows

25 p.

Properties of convergence of a class of iterative processes generated by sequences of self-mappings with applications to switched dynamic systems

This article investigates the convergence properties of iterative processes involving sequences of self-mappings of metric or Banach spaces. Such sequences are built from a set of primary self-mappings which are either expansive or non-expansive self-mappings and some of the non-expansive ones can be contractive including the case of strict contractions. The sequences are built subject to switching laws which select each active self-mapping on a certain activation interval in such a way that essential properties of boundedness and convergence of distances and iterated sequences are guaranteed. Applications to the important problem of stability of dynamic switched systems are also given.

Advantages and Versatility of Fluorescence-Based Methodology to Characterize the Functionality of LDLR and Class Mutation Assignment

Familial hypercholesterolemia (FH) is a common autosomal codominant disease with a frequency of 1:500 individuals in its heterozygous form. The genetic basis of FH is most commonly mutations within the LDLR gene. Assessing the pathogenicity of LDLR variants is particularly important to give a patient a definitive diagnosis of FH. Current studies of LDLR activity ex vivo are based on the analysis of I-125-labeled lipoproteins (reference method) or fluorescent-labelled LDL. The main purpose of this study was to compare the effectiveness of these two methods to assess LDLR functionality in order to validate a functional assay to analyse LDLR mutations. LDLR activity of different variants has been studied by flow cytometry using FITC-labelled LDL and compared with studies performed previously with I-125-labeled lipoproteins. Flow cytometry results are in full agreement with the data obtained by the I-125 methodology. Additionally confocal microscopy allowed the assignment of different class mutation to the variants assayed. Use of fluorescence yielded similar results than I-125-labeled lipoproteins concerning LDLR activity determination, and also allows class mutation classification. The use of FITC-labelled LDL is easier in handling and disposal, cheaper than radioactivity and can be routinely performed by any group doing LDLR functional validations.