[R_Cornago_Castillo] Documentación Geométrica y Modelado Virtual del Castillo de Cornago (La Rioja)

[ES] El Castillo se encuentra coronando, junto a la iglesia de San Pedro, el cerro sobre el que se asienta el caserío de Cornago. Actualmente está formado por un patio interior de forma rectangular y rematado por cuatro torres en las esquinas, de las cuales tres son circulares de diferentes radios y una cuarta (NE) cuadrada, la superficie total ocupada es de unos 50 x 30 metros al exterior.

[R_Arnedo_SanMiguel] Documentación geométrica de las excavaciones arqueológicas del Cerro de San Miguel (Arnedo, La Rioja)

[ES] El cerro de San Miguel de Arnedo alberga un importante asentamiento plenamente adscrito a la cultura celtibérica. Los restos documentados corresponden a dos conjuntos de viviendas y una estructura defensiva compuesta por un foso y restos de muralla.

[R_Arnedo_SanMiguel] Documentación geométrica de las excavaciones arqueológicas del Cerro de San Miguel (Arnedo, La Rioja). Campaña 2007

[ES] El cerro de San Miguel de Arnedo alberga un importante asentamiento plenamente adscrito a la cultura celtibérica. Los restos documentados corresponden a dos conjuntos de viviendas y una estructura defensiva compuesta por un foso y restos de muralla.

Cartas enviadas por A. Nathan Womack a Justo Garate entre 1945 y 1956

2 cartas (mecanografiadas) ; 200x267mm

[R_Lumbreras_CastilloMonjes] Documentación geométrica del Castro de los Monjes. Lumbreras, La Rioja

[ES] En lo alto del cerro se encuentra un sistema de cuatro recintos amurallados de piedra en seco que se disponen sobre un espolón rocoso de forma triangular de unos 150 metros de longitud y 100 metros de base.

HPV infection, a described cause for human cancer: HPV detection and molecular mechanisms of HPV carcinogenesis (Review).

[en]Human papillomavirus (HPV) belongs to the Papillomaviridae virus family and it is one of the most common sexual transmission infections. HPV genome is composed of eight genes, including two early genes and six late genes. Among these late genes, E6 and E7 code for proteins that trigger cell-cycle re-entry in infected cells, which can lead to cervical cancer development. The IARC (International Agency for Research Cancer) proposed a guideline based on Hill’s criteria to determine whether the relation between HPV infection and cervical cancer is causal or not. Epidemiological studies have demonstrated that HPV infection is a necessary but non-sufficient cause for cervical cancer. Furthermore, HPV infection is considered the first necessary cause described of a human cancer, being HPV16 and 18 carcinogenic to humans and the most studied types. Cervical cancer is the second leading cause of cancer death among women worldwide. Different screening programs are carried out with the aim of preventing cervical cancer; such as cytologies and HPV tests. There are two main methods which are equally usable to detect HPV: the real-time PCR assays and the array assays. Regarding the molecular mechanisms of HPV mediated malignancies, E2, E6 and E7 proteins of HPV16 lead to immune response evasion, inducing IL-10 and TGF-β1 gene expression. Besides, E6 and E7 proteins allow cell-cycle reentry, phosphorylating RB and ubiquitinating p53 respectively. HPV genome integration in host genome leads to the alteration of host and viral genes expression, including oncogenes and tumor suppressor genes. However, the differences of E6 and E7 oncoproteins in different HPV types is poorly known due to the fact that almost the most studied HPV type has been HPV16.