Efectos neurovasculares y cognitivos de la administración intracortical del VEGF y el enriquecimiento ambiental durante el desarrollo postnatal de ratas Long Evans

140 págs.

Laugarren mundua: herri indigenen erbeste ekintza, onespen eta aldaketa eragile nazioarteko harremanetan 1992-2007

[EUS] Jasandako kolonizazioaren poderioz herri indigenak domestikatu eta ikusezinak bihurtu egin dituzte urte askotan. Gauzak erabat aldatu egin dira azken bolada honetan indigenek martxan kanpo ekintzari esker gai izan baitira euren irudia eta nazioarteko agenda propioa bultzatzeko. Era honetan lortu egin dute aktore berri bezala nazioarteko erkidegoan onartuak izatea, eta ondorioz sustatu egin dituzte euren aldeko gertatu diren hainbat aldaketa garrantzitsuak. Hauen artean aipamen berezia merezi du Herri Indigenen Eskubideen Aldeko Aldarrikapen Unibertsalak, 2007an onartu zena. Doktorego tesi honetan herri indigenek nazioartean propio aritzeko sorturiko Laugarren Mundua delako mugimenduaren azterketa egiten da. Errotik mugimendu antikolonialista izanik kolonialismo uhin ezberdinek sorturiko egoera aztertzen da. Geroxeago honen aurka aritu izan den mundo mailako mugimendu indigenaren sorrera, agenda eta ekimen eremu nagusiak aztertu direlarik. Ekintza eremuen artean aipamen berezia merezi dute giza eskubideen eremuan zein ekologian egindakoak.

Increased physical activity is not enough to recover astrocytic population from dark-rearing. Synergy with multisensory enrichment is required

10 p.

Sistema software para el control de producción de la unidad de rodajes

El presente proyecto consiste en el análisis y búsqueda de soluciones para el control de producción de la unidad de rodajes de la compañía CAF S.A. Para ello, se ha tenido que analizar procesos de producción, capturar requerimientos, desarrollar unas herramientas de control de producción temporales y elaborar una especificación de requisitos. Sin olvidar la gestión e interlocución con proveedores. Estas líneas de trabajo se encuentran descritas en esta memoria, junto con análisis de resultados, conclusiones y unas líneas futuras donde se seguirá trabajando.

An Embedded Stress Sensor for Concrete SHM Based on Amorphous Ferromagnetic Microwires

A new smart concrete aggregate design as a candidate for applications in structural health monitoring (SHM) of critical elements in civil infrastructure is proposed. The cement-based stress/strain sensor was developed by utilizing the stress/strain sensing properties of a magnetic microwire embedded in cement-based composite (MMCC). This is a contact-less type sensor that measures variations of magnetic properties resulting from stress variations. Sensors made of these materials can be designed to satisfy the specific demand for an economic way to monitor concrete infrastructure health. For this purpose, we embedded a thin magnetic microwire in the core of a cement-based cylinder, which was inserted into the concrete specimen under study as an extra aggregate. The experimental results show that the embedded MMCC sensor is capable of measuring internal compressive stress around the range of 1-30 MPa. Two stress sensing properties of the embedded sensor under uniaxial compression were studied: the peak amplitude and peak position of magnetic switching field. The sensitivity values for the amplitude and position within the measured range were 5 mV/MPa and 2.5 mu s/MPa, respectively.

Enseñanza-aprendizaje del inglés en las pymes exportadoras de Bizkaia: identificación de necesidades y propuestas de mejora

343 p.

Morphofunctional changes in a rat model of Parkinson's disease - Effects of neurotrophic factors administration

255 p.

Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease

Current research efforts are focused on the application of growth factors, such as glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), as neuroregenerative approaches that will prevent the neurodegenerative process in Parkinson's disease. Continuing a previous work published by our research group, and with the aim to overcome different limitations related to growth factor administration, VEGF and GDNF were encapsulated in poly(lactic-co-glycolic acid) nanospheres (NS). This strategy facilitates the combined administration of the VEGF and GDNF into the brain of 6-hydroxydopamine (6-OHDA) partially lesioned rats, resulting in a continuous and simultaneous drug release. The NS particle size was about 200 nm and the simultaneous addition of VEGF NS and GDNF NS resulted in significant protection of the PC-12 cell line against 6-OHDA in vitro. Once the poly(lactic-co-glycolic acid) NS were implanted into the striatum of 6-OHDA partially lesioned rats, the amphetamine rotation behavior test was carried out over 10 weeks, in order to check for in vivo efficacy. The results showed that VEGF NS and GDNF NS significantly decreased the number of amphetamine-induced rotations at the end of the study. In addition, tyrosine hydroxylase immunohistochemical analysis in the striatum and the external substantia nigra confirmed a significant enhancement of neurons in the VEGF NS and GDNF NS treatment group. The synergistic effect of VEGF NS and GDNF NS allows for a reduction of the dose by half, and may be a valuable neurogenerative/neuroreparative approach for treating Parkinson's disease.

Las Asociaciones Estratégicas : El instrumento de política exterior de la Unión Europea frente al nuevo orden mundial

El presente trabajo realiza un análisis de las Asociaciones Estratégicas de la Unión Europea. Se tratan de un instrumento de política exterior de la Unión, para hacer frente al nuevo orden mundial. Por ello, el trabajo presenta el sistema internacional actual al que se enfrenta la Unión, analiza las Asociaciones Estratégicas (características, funciones y límites) y realiza un breve análisis de los 10 socios estratégicos con quienes se han establecido dichas asociaciones. El trabajo está redactado en castellano.

Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness

Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 (TSC1 or TSC2) genes. While allosteric inhibition of the mechanistic target of rapamycin (mTOR) has shown substantial clinical benefit, complementary therapies are required to improve response and/or to treat specific patients. However, there is a lack of LAM biomarkers that could potentially be used to monitor the disease and to develop other targeted therapies. We hypothesized that the mediators of cancer metastasis to lung, particularly in breast cancer, also play a relevant role in LAM. Analyses across independent breast cancer datasets revealed associations between low TSC1/2 expression, altered mTOR complex 1 (mTORC1) pathway signaling, and metastasis to lung. Subsequently, immunohistochemical analyses of 23 LAM lesions revealed positivity in all cases for the lung metastasis mediators fascin 1 (FSCN1) and inhibitor of DNA binding 1 (ID1). Moreover, assessment of breast cancer stem or luminal progenitor cell biomarkers showed positivity in most LAM tissue for the aldehyde dehydrogenase 1 (ALDH1), integrin-beta 3 (ITGB3/CD61), and/or the sex-determining region Y-box 9 (SOX9) proteins. The immunohistochemical analyses also provided evidence of heterogeneity between and within LAM cases. The analysis of Tsc2-deficient cells revealed relative over-expression of FSCN1 and ID1; however, Tsc2-deficient cells did not show higher sensitivity to ID1-based cancer inhibitors. Collectively, the results of this study reveal novel LAM biomarkers linked to breast cancer metastasis to lung and to cell stemness, which in turn might guide the assessment of additional or complementary therapeutic opportunities for LAM.