The IRYSS-COPD appropriateness study: objectives, methodology, and description of the prospective cohort

Background: Patients with chronic obstructive pulmonary disease (COPD) often experience exacerbations of the disease that require hospitalization. Current guidelines offer little guidance for identifying patients whose clinical situation is appropriate for admission to the hospital, and properly developed and validated severity scores for COPD exacerbations are lacking. To address these important gaps in clinical care, we created the IRYSS-COPD Appropriateness Study. Methods/Design: The RAND/UCLA Appropriateness Methodology was used to identify appropriate and inappropriate scenarios for hospital admission for patients experiencing COPD exacerbations. These scenarios were then applied to a prospective cohort of patients attending the emergency departments (ED) of 16 participating hospitals. Information was recorded during the time the patient was evaluated in the ED, at the time a decision was made to admit the patient to the hospital or discharge home, and during follow-up after admission or discharge home. While complete data were generally available at the time of ED admission, data were often missing at the time of decision making. Predefined assumptions were used to impute much of the missing data. Discussion: The IRYSS-COPD Appropriateness Study will validate the appropriateness criteria developed by the RAND/UCLA Appropriateness Methodology and thus better delineate the requirements for admission or discharge of patients experiencing exacerbations of COPD. The study will also provide a better understanding of the determinants of outcomes of COPD exacerbations, and evaluate the equity and variability in access and outcomes in these patients.

Length of concentrate finishing affects the fatty acid composition of grass-fed andgenetically lean beef: an emphasis on trans-18:1 and conjugated linoleic acid profiles

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Second-to-Fourth Digit Ratio Has a Non-Monotonic Impact on Altruism

Gene-culture co-evolution emphasizes the joint role of culture and genes for the emergence of altruistic and cooperative behaviors and behavioral genetics provides estimates of their relative importance. However, these approaches cannot assess which biological traits determine altruism or how. We analyze the association between altruism in adults and the exposure to prenatal sex hormones, using the second-to-fourth digit ratio. We find an inverted U-shaped relation for left and right hands, which is very consistent for men and less systematic for women. Subjects with both high and low digit ratios give less than individuals with intermediate digit ratios. We repeat the exercise with the same subjects seven months later and find a similar association, even though subjects' behavior differs the second time they play the game. We then construct proxies of the median digit ratio in the population (using more than 1000 different subjects), show that subjects' altruism decreases with the distance of their ratio to these proxies. These results provide direct evidence that prenatal events contribute to the variation of altruistic behavior and that the exposure to fetal hormones is one of the relevant biological factors. In addition, the findings suggest that there might be an optimal level of exposure to these hormones from social perspective.

Prevención de la agresividad y la violencia en el deporte en edad escolar: Un estudio de revisión.

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Urte biko gelako gatazkak: izaera eta esku-hartzea

[EUS] Ikerketa lan honen helburua urte biko gela batean ematen diren egoera gatazkatsuak eta horietan burutzen diren esku-hartze mota desberdinak aztertzea izan da. Horretarako, bi alditan banandu da ikerketa honen zeregina: fase esploratzailean eta fase zientifikoan, hain zuzen. Lehenengoan, gaiari buruzko hausnarketa teoriko sakon bat gauzatzearekin batera, ikerketaren behaketa esparruak zehaztu dira, hala nola, zer, noiz, non eta nola behatuko den. Orduan, goizeko une gatazkatsuenak behatzea erabaki da; saio kolektiboa, txokoak eta batzeko unea, hain zuzen. Ondoren, fase zientifikoan, hiru esparru horietan behatutako datu guztiak bildu eta hainbat taula eta grafiko eratu dira. Lortutako emaitzen arabera, argi gelditu delarik eskolan biolentzia erabiltzea nahiko ohikoa dela; autoritarismoa, diziplina inposaketa eta boterearen erabilera bortitza. Hori dela eta, batetik garatutako lan enpirikoan eta bestetik Pikler-Lóczy eskolatze goiztiarraren hezkuntza-eredu arrakastatsuan oinarritutako hausnarketa egin da, gatazka egoeretan erabili daitezkeen baliabide nahiz esku-hartze mota kalitatezko eta egokiagoak eskaintzeko asmotan.