Estudio de la actividad aminopeptidásica en espermatozoides astenozoospérmicos : comparación clínica

249 p.: il., col.

Trafikoaren monitorizazioa datu sareetan. Firewall errendimendu analisia

[EU]Gaur egungo sareetan egunetik egunera garraiatzen den paketeen trafikoa handituz doa eskariak horrela behartzen duelako. Beste alde batetik, gure sareen eta batez ere sare pribatuen segurtasuna gero eta garrantzitsuagoa da, bertan dauden datuen eskuragarritasuna mugatze aldera. Ondorioz segurtasun teknika hauek aplikatzeko ahalik eta denbora gutxien erabiltzea garrantzitsua da sareak duen datu garraiorako errendimendu altua manten dezan, segurtasuna bermatua. Proiektu honetan, enpresa eta erakundeetan oso arruntak diren firewall, segurtasun tekniken inguruko azterketa egingo da. Firewall ezagun baten eta driver baten arteko integrazioa burutuko da firewallak sarean duen errendimendua hobetze aldera.

Estudio del Sistema Renina Angiotensina como posible biomarcador para la mejora de los tratamientos de fecundación in vitro

287 p.

Expression and Localization of Opioid Receptors in Male Germ Cells and the Implication for Mouse Spermatogenesis

The presence of endogenous opioid peptides in different testicular cell types has been extensively characterized and provides evidence for the participation of the opioid system in the regulation of testicular function. However, the exact role of the opioid system during the spermatogenesis has remained controversial since the presence of the mu-, delta-and kappa-opioid receptors in spermatogenic cells was yet to be demonstrated. Through a combination of quantitative real-time PCR, immunofluorescence, immunohistochemistry and flow cytometry approaches, we report for the first time the presence of active mu-, deltaand kappa-opioid receptors in mouse male germ cells. They show an exposition time-dependent response to opioid agonist, hence suggesting their active involvement in spermatogenesis. Our results contribute to understanding the role of the opioid receptors in the spermatogenesis and could help to develop new strategies to employ the opioid system as a biochemical tool for the diagnosis and treatment of male infertility.