Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease

The formation of cerebral senile plaques composed of amyloid beta peptide (A beta) is a fundamental feature of Alzheimer's disease (AD). Glial cells and more specifically microglia become reactive in the presence of A beta. In a triple transgenic model of AD (3 x Tg-AD), we found a significant increase in activated microglia at 12 (by 111%) and 18 (by 88%) months of age when compared with non-transgenic (non-Tg) controls. This microglial activation correlated with A beta plaque formation, and the activation in microglia was closely associated with A beta plaques and smaller A beta deposits. We also found a significant increase in the area density of resting microglia in 3 x Tg-AD animals both at plaque-free stage (at 9 months by 105%) and after the development of A plaques (at 12 months by 54% and at 18 months by 131%). Our results show for the first time that the increase in the density of resting microglia precedes both plaque formation and activation of microglia by extracellular A beta accumulation. We suggest that AD pathology triggers a complex microglial reaction: at the initial stages of the disease the number of resting microglia increases, as if in preparation for the ensuing activation in an attempt to fight the extracellular A beta load that is characteristic of the terminal stages of the disease. Cell Death and Disease (2010) 1, e1; doi:10.1038/cddis.2009.2; published online 14 January 2010

Familias monoparentales: satisfacción vital en madres jóvenes inmigrantes

[SPA] Conocer el bienestar psicológico subjetivo y satisfacción vital de quienes asumen la responsabilidad de las familias monoparentales mejora la acción educativa, ayudando a prevenir situaciones de riesgo y exclusión social. Este trabajo presenta el análisis de la satisfacción vital expresada por un grupo de madres jóvenes inmigrantes al frente de familias monomarentales usuarias del Programa Beregain de la Fundación Itaka-Escolapios (Bilbao). Se realizaron entrevistas individuales semiestructuradas a las madres que integran la muestra. El análisis e interpretación de datos se llevaron a cabo conforme a una metodología cualitativa, específicamente el estudio de casos. Los resultados revelaron la escasa satisfacción en ciertos ámbitos vitales relacionados con las relaciones interpersonales, el ocio, la conciliación del cuidado de sus hijos/as con la propia formación, y la imposibilidad de hacer frente a los gastos económicos sin la ayuda que reciben por parte de la fundación.