An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines

18 p.

Valoración de la Cooperación Inter-empresarial en las Microempresas del Municipio de Murcia, proyectos Micro y e-Micro (2002-2007)

[ES] El marco teórico del trabajo tiene como finalidad explicar los procesos de cooperación diseñados para las microempresas, con el propósito de establecer propuestas y argumentos para la formación de acuerdos, identificar los factores que afectan el desarrollo de los mismos, así como los sistemas de innovación nacional, regional y local para la animación de la cooperación entre firmas. Con ello, se propone una metodología para promover la cooperación entre microempresas, coordinada por agentes locales y la administración pública de los proyectos Micro y e-Micro (2002-2007) de la ciudad de Murcia.

Clinical factors associated with a Candida albicans Germ Tube Antibody positive test in Intensive Care Unit patients

Background: Poor outcomes of invasive candidiasis (IC) are associated with the difficulty in establishing the microbiological diagnosis at an early stage. New scores and laboratory tests have been developed in order to make an early therapeutic intervention in an attempt to reduce the high mortality associated with invasive fungal infections. Candida albicans IFA IgG has been recently commercialized for germ tube antibody detection (CAGTA). This test provides a rapid and simple diagnosis of IC (84.4% sensitivity and 94.7% specificity). The aim of this study is to identify the patients who could be benefited by the use of CAGTA test in critical care setting. Methods: A prospective, cohort, observational multicentre study was carried out in six medical/surgical Intensive care units (ICU) of tertiary-care Spanish hospitals. Candida albicans Germ Tube Antibody test was performed twice a week if predetermined risk factors were present, and serologically demonstrated candidiasis was considered if the testing serum dilution was >= 1: 160 in at least one sample and no other microbiological evidence of invasive candidiasis was found. Results: Fifty-three critically ill non-neutropenic patients (37.7% post surgery) were included. Twenty-two patients (41.5%) had CAGTA-positive results, none of them with positive blood culture for Candida. Neither corrected colonization index nor antifungal treatment had influence on CAGTA results. This finding could corroborate that the CAGTA may be an important biomarker to distinguish between colonization and infection in these patients. The presence of acute renal failure at the beginning of the study was more frequent in CAGTA-negative patients. Previous surgery was statistically more frequent in CAGTA-positive patients. Conclusions: This study identified previous surgery as the principal clinical factor associated with CAGTA-positive results and emphasises the utility of this promising technique, which was not influenced by high Candida colonization or antifungal treatment. Our results suggest that detection of CAGTA may be important for the diagnosis of invasive candidiasis in surgical patients admitted in ICU.

Evolución de la tecnología micro-nanoelectrónica a través de patentes

El trabajo tiene como objetivos mostrar el uso de las patentes como medio de difusión de conocimiento y encontrar las claves más significativas de la evolución de la tecnología escogida.

A Novel Micro- and Nano-Scale Positioning Sensor Based on Radio Frequency Resonant Cavities

In many micro- and nano-scale technological applications high sensitivity displacement sensors are needed, especially in ultraprecision metrology and manufacturing. In this work a new way of sensing displacement based on radio frequency resonant cavities is presented and experimentally demonstrated using a first laboratory prototype. The principle of operation of the new transducer is summarized and tested. Furthermore, an electronic interface that can be used together with the displacement transducer is designed and proved. It has been experimentally demonstrated that very high and linear sensitivity characteristic curves, in the range of some kHz/nm; are easily obtainable using this kind of transducer when it is combined with a laboratory network analyzer. In order to replace a network analyzer and provide a more affordable, self-contained, compact solution, an electronic interface has been designed, preserving as much as possible the excellent performance of the transducer, and turning it into a true standalone positioning sensor. The results obtained using the transducer together with a first prototype of the electronic interface built with cheap discrete elements show that positioning accuracies in the micrometer range are obtainable using this cost-effective solution. Better accuracies would also be attainable but using more involved and costly electronics interfaces.

Un análisis sobre la financiación colectiva: el micro-mecenazgo

[ES]Este es un Trabajo Fin de Grado interdisciplinar que aúna el Micro-mecenazgo con la Econometría. En la parte teórica, se sintetiza la literatura relacionada con el crowdfunding, los tipos y su funcionamiento, así como los factores que influyen tanto positiva como negativamente en la consecución de los proyectos llevados a cabo por esta práctica. Se analizan también las bases de datos sobre plataformas de crowdfunding disponibles en Internet y se explica la búsqueda realizada para encontrar una muestra adecuada. Mientras que en la parte empírica, se analiza el impacto de los factores elegidos sobre la probabilidad de éxito de los proyectos. Para ello se utilizan modelos econométricos no estudiados anteriormente que se explican y analizan en la parte metodológica del trabajo. De esta forma, se obtienen resultados que ayudan a conocer las características que han de tener los proyectos publicados en las plataformas de crowdfunding para conseguir la financiación exigida. Para ello, se han teniendo en cuenta los datos encontrados en diferentes plataformas de crowdfunding entre el año 2013 y el 2015.