Efficient Gate-tunable light-emitting device made of defective boron nitride nanotubes: from ultraviolet to the visible

Boron nitride is a promising material for nanotechnology applications due to its two-dimensional graphene-like, insulating, and highly-resistant structure. Recently it has received a lot of attention as a substrate to grow and isolate graphene as well as for its intrinsic UV lasing response. Similar to carbon, one-dimensional boron nitride nanotubes (BNNTs) have been theoretically predicted and later synthesised. Here we use first principles simulations to unambiguously demonstrate that i) BN nanotubes inherit the highly efficient UV luminescence of hexagonal BN; ii) the application of an external perpendicular field closes the electronic gap keeping the UV lasing with lower yield; iii) defects in BNNTS are responsible for tunable light emission from the UV to the visible controlled by a transverse electric field (TEF). Our present findings pave the road towards optoelectronic applications of BN-nanotube-based devices that are simple to implement because they do not require any special doping or complex growth

Randomised, crossover clinical trial, in healthy volunteers, to compare the systemic availability of two topical intranasal budesonide formulations

Background: Budesonide has a long history as intranasal drug, with many marketed products. Efforts should be made to demonstrate the therapeutic equivalence and safety comparability between them. Given that systemic availability significantly varies from formulations, the clinical comparability of diverse products comes to be of clinical interest and a regulatory requirement. The aim of the present study was to compare the systemic availability, pharmacodynamic effect, and safety of two intranasal budesonide formulations for the treatment of rhinitis. Methods: Eighteen healthy volunteers participated in this randomised, controlled, crossover, clinical trial. On two separated days, subjects received a single dose of 512 mu g budesonide (4 puffs per nostril) from each of the assayed devices (Budesonida nasal 64 (R), Aldo-Union, Spain and Rhinocort 64 (R), AstraZeneca, Spain). Budesonide availability was determined by the measurement of budesonide plasma concentration. The pharmacodynamic effect on the hypothalamic-adrenal axis was evaluated as both plasma and urine cortisol levels. Adverse events were tabulated and described. Budesonide availability between formulations was compared by the calculation of 90% CI intervals of the ratios of the main pharmacokinetic parameters describing budesonide bioavailability. Plasma cortisol concentration-time curves were compared by means of a GLM for Repeated Measures. Urine cortisol excretion between formulations was compared through the Wilcoxon's test. Results: All the enroled volunteers successfully completed the study. Pharmacokinetic parameters were comparable in terms of AUC(t) (2.6 +/- 1.5 vs 2.2 +/- 0.7), AUCi (2.9 +/- 1.5 vs 2.4 +/- 0.7), t(max) (0.4 +/- 0.1 vs 0.4 +/- 0.2), C(max)/AUC(i) (0.3 +/- 0.1 vs 0.3 +/- 0.0), and MRT (5.0 +/- 1.4 vs 4.5 +/- 0.6), but not in the case of C(max) (0.9 +/- 0.3 vs 0.7 +/- 0.2) and t(1/2) (3.7 +/- 1.8 vs 2.9 +/- 0.4). The pharmacodynamic effects, measured as the effect over plasma and urine cortisol, were also comparables between both formulations. No severe adverse events were reported and tolerance was comparable between formulations. Conclusion: The systemic availability of intranasal budesonide was comparable for both formulations in terms of most pharmacokinetic parameters. The pharmacodynamic effect on hypothalamic-pituitary-adrenal axis was also similar. Side effects were scarce and equivalent between the two products. This methodology to compare different budesonide-containing devices is reliable and easy to perform, and should be recommended for similar products intented to be marketed or already on the market.

The Determinants of Energy Efficiency Investments in the U.S.

31 p.

Optimisation of the first principle code Octopus for massive parallel architectures: application to light harvesting complexes

150 p.

Shedding light on TQM: some research findings

Over the last decad , the paradigm of Total Quality Management (TQM) has been successfully forged in our business world. TQM may be defined as something that is both complex and ambiguous; nevertheless, some key elements or principles can be mentioned which are common to all of them: customer satisfaction, continuous improvement, commitment and leadership on the part of top management, involvement and support on the part of employees, teamwork, measurement via indicators and feedback. There are, in short, two main reasons for it having spread so widely: on the one hand, the successful diffusion of ISO 9000 standards for the implementation and certification of quality management systems, standards that have been associated to the TQM paradigm, and, on the other, the also successful diffusion of self evaluation models such as the EFQM promoted by the European Foundation for Quality Management and the Malcolm Baldrige National Quality Award in the USA, promoted by the Foundation for the Malcolm Baldrige National Quality Award. However, the quality movement is not without its problems as far as its mid and long term development is concerned. In this book some research findings related to these issues are presented.

Ultrastrong light-matter interaction in quantum technologies

120 p.

Comparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation

We analysed the whole-genome transcriptional profile of 6 cell lines of dark melanocytes (DM) and 6 of light melanocytes (LM) at basal conditions and after ultraviolet-B (UVB) radiation at different time points to investigate the mechanisms by which melanocytes protect human skin from the damaging effects of UVB. Further, we assessed the effect of different keratinocyte-conditioned media (KCM+ and KCM-) on melanocytes. Our results suggest that an interaction between ribosomal proteins and the P53 signaling pathway may occur in response to UVB in both DM and LM. We also observed that DM and LM show differentially expressed genes after irradiation, in particular at the first 6h after UVB. These are mainly associated with inflammatory reactions, cell survival or melanoma. Furthermore, the culture with KCM+ compared with KCM- had a noticeable effect on LM. This effect includes the activation of various signaling pathways such as the mTOR pathway, involved in the regulation of cell metabolism, growth, proliferation and survival. Finally, the comparison of the transcriptional profiles between LM and DM under basal conditions, and the application of natural selection tests in human populations allowed us to support the significant evolutionary role of MIF and ATP6V0B in the pigmentary phenotype.

Energy and momentum transfer in one-dimensional trapped gases by stimulated light scattering

In ultracold atoms settings, inelastic light scattering is a preeminent technique to reveal static and dynamic properties at nonzero momentum. In this work, we investigate an array of one-dimensional trapped Bose gases, by measuring both the energy and the momentum imparted to the system via light scattering experiments. The measurements are performed in the weak perturbation regime, where these two quantities-the energy and momentum transferred-are expected to be related to the dynamic structure factor of the system. We discuss this relation, with special attention to the role of in-trap dynamics on the transferred momentum.

Klima-aldaketaren eraginak euskal kostaldeko mendebaldeko sakonera handiko begetazio azpimarealean

[eus] Euskal kostaldeko mareazpiko begetazioak aldaketa esanguratsuak jasan ditu azken hiru hamarkadetan. Aurretik egindako ikerketek jakinarazi dute aldaketa horiek klima-aldaketak eragindakoak direla. Ikerketa honen helburua inpaktu horri buruzko informazio gehiago lortzea da. Horretarako, sakonera handiko uretako fitobentosaren osaerari eta ugaritasunari buruzko balioespena egin da. 2014. urteko udan 7 trantsektu ezarri ziren, Kobaroneko muturretik Muskizeko muturreraino. Trantsektu horiek aurretik ikertuak izan ziren 1982 eta 2007 urteetan, eta laginketa suntsitzailea egin zen. Analisi estatistikoek aldaketa esanguratsuak erakusten dituzte sakoneko (9-11m) komunitateetan azken 32 urteetan. Uraren tenperaturaren emendioa eta eguzki-erradiazio altuagoa detektatutako aldaketen erantzuleak izan daitezke neurri batean. Pterosiphonia complanata espezie esziafiloaren gainbeherak eta Cystoseira baccata eta Aphanocladia stichidiosa espezieen ugaritzeak hipotesi hori azaltzen dute. Espero genuenaren kontra, Gelidium corneum espeziea, sakontasun gutxiko uretan gainbehera bortitza jasaten ari dena, ez da 9 metrotik beherako sakonerara lekualdatu. Hala ere, ezin da ziurtatu egungo ingurumeneko baldintzak optimoak ez direnik G. corneum espeziearen garapenerako 9-11 metroko sakoneretan. Migrazio bertikal hori ez gertatzearen arrazoi onargarriena C. baccata- rekiko lehiakortasuna dela dirudi. Bestalde, C. baccata hiru dimentsiotako habitatak eratzeko gai den tamaina handiko alga bat da, espezie askorentzat babesleku gisa diharduena. Ondorioz, haren hedapenak G. corneum-ek sakonera txikiagoetan betetzen zuen funtzioa ordezka lezake neurri batean.