Efficacy and safety of autologous platelet rich plasma for the treatment of vascular ulcers in primary care: Phase III study

Background: Vascular ulcers are commonly seen in daily practice at all levels of care and have great impact at personal, professional and social levels with a high cost in terms of human and material resources. Given that the application of autologous platelet rich plasma has been shown to decrease healing times in various different studies in the hospital setting, we considered that it would be interesting to assess the efficacy and feasibility of this treatment in primary care. The objectives of this study are to assess the potential efficacy and safety of autologous platelet rich plasma for the treatment of venous ulcers compared to the conventional treatment (moist wound care) in primary care patients with chronic venous insufficiency (C, clinical class, E, aetiology, A, anatomy and P, pathophysiology classification C6). Design: We will conduct a phase III, open-label, parallel-group, multicentre, randomized study. The subjects will be 150 patients aged between 40 and 100 years of age with an at least 2-month history of a vascular venous ulcer assigned to ten primary care centres. For the treatment with autologous platelet rich plasma, all the following tasks will be performed in the primary care setting: blood collection, centrifugation, separation of platelet rich plasma, activation of coagulation adding calcium chloride and application of the PRP topically after gelification. The control group will receive standard moist wound care. The outcome variables to be measured at baseline, and at weeks 5 and 9 later include: reduction in the ulcer area, Chronic Venous Insufficiency Quality of Life Questionnaire score, and percentage of patients who require wound care only once a week. Discussion: The results of this study will be useful to improve the protocol for using platelet rich plasma in chronic vascular ulcers and to favour wider use of this treatment in primary care.

Unidades organizativas indígenas del área indoeuropea de Hispania III: addenda

[ES] Se ofrecen los nuevos nombres, repetidos o no, de unidades organizativas indígenas (cognationes, gentes y gentilitates) aparecidos desde la década de los 90 del pasado siglo y documentados en la epigrafía latina y celtibérica de la Hispania indoeuropea

Fixed Points of Closed and Compact Composite Sequences of Operators and Projectors in a Class of Banach Spaces

Some results on fixed points related to the contractive compositions of bounded operators in a class of complete metric spaces which can be also considered as Banach's spaces are discussed through the paper. The class of composite operators under study can include, in particular, sequences of projection operators under, in general, oblique projective operators. In this paper we are concerned with composite operators which include sequences of pairs of contractive operators involving, in general, oblique projection operators. The results are generalized to sequences of, in general, nonconstant bounded closed operators which can have bounded, closed, and compact limit operators, such that the relevant composite sequences are also compact operators. It is proven that in both cases, Banach contraction principle guarantees the existence of unique fixed points under contractive conditions.

La importancia de la iteración fonética en la traducción del texto shakespeariano: la aliteración en Ricardo III

Eterio Pajares, Raquel Merino y José Miguel Santamaría (eds.)

On a Class of Self-Adjoint Compact Operators in Hilbert Spaces and Their Relations with Their Finite-Range Truncations

This paper investigates a class of self-adjoint compact operators in Hilbert spaces related to their truncated versions with finite-dimensional ranges. The comparisons are established in terms of worst-case norm errors of the composite operators generated from iterated computations. Some boundedness properties of the worst-case norms of the errors in their respective fixed points in which they exist are also given. The iterated sequences are expanded in separable Hilbert spaces through the use of numerable orthonormal bases.

Asymptotic Hyperstability of a Class of Linear Systems under Impulsive Controls Subject to an Integral Popovian Constraint

This paper is focused on the study of the important property of the asymptotic hyperstability of a class of continuous-time dynamic systems. The presence of a parallel connection of a strictly stable subsystem to an asymptotically hyperstable one in the feed-forward loop is allowed while it has also admitted the generation of a finite or infinite number of impulsive control actions which can be combined with a general form of nonimpulsive controls. The asymptotic hyperstability property is guaranteed under a set of sufficiency-type conditions for the impulsive controls.

Genetics of Type III Bartter Syndrome in Spain, Proposed Diagnostic Algorithm

9 p.

Ekonomian lizentziaturako matematika III. Azterketak

irakasgaia gainditu behar duten ikasleentzat, eta baita ere, gai batzuetan, gradu berriko Matematika I eta Matematika II irakasgaiko ikasleentzat.Ekonomian Lizentziaturako Matematika III irakasgaiko azken hamar urteetan jarri diren azterketak eta haien erantzunak aurkituko dituzue. Lehenengo zatian, egin gabeko azterketak daude, ordena kronologikoan, zaharrenetik berrienera, eta bigarren zatian, erantzunak daude, ordena kronologikoan ere baina gaika ere. Horrela, programaren gai bakoitzaren ariketa guztiak elkarrekin aurkituko dituzue, gaiz gai ikasi nahi izanez gero.

Enpresen administrazio eta zuzendaritzako lizentziaturako matematika III. Azterketak

Enpresen Administrazio eta Zuzendaritzako Lizentziaturako Matematika III irakasgaia gainditu behar duten ikasleentzat, eta baita ere, gai batzuetan, gradu berriko Matematika I eta Matematika II irakasgaiko ikasleentzat.Enpresen Administrazio eta Zuzendaritzako Lizentziaturako Matematika III irakasgaiko azken hamar urteetan jarri diren azterketak eta haien erantzunak aurkituko dituzue. Lehenengo zatian, egin gabeko azterketak daude, ordena kronologikoan, zaharrenetik berrienera, eta bigarren zatian, erantzunak daude, ordena kronologikoan ere baina gaika ere. Horrela, programaren gai bakoitzaren ariketa guztiak elkarrekin aurkituko dituzue, gaiz gai ikasi nahi izanez gero.

Design, analysis and implementation of a versatile low level radio frequency system for accelerating cavities

179 p.

Jarduera Fisikoaren orokortasunak bihotz-errehabilitazioaren III. faseko programa batean

Bihotz - errehabilitazioaren III. fasean alderdi ezberdinak hartu behar dira kontuan eta lan honek, alderdi ezberdin hauek azaldu nahi izan dit u: patologia ezberdinak azaltzea , jarduera fisikoaren orokortasunak eta entrena mendu metodo ezberdinak azaltzea eta azkenik, patologia zehatzen arabera kont uan hartu beharrekoak azaltzea Orain arte bihotz - errehabilitazioaren barruan entrenamendu aerobiko jarraia soilik landu den arren, lan honek entrenamendu aerobiko interbalikoaren onura adierazgarriak baieztatzen ditu: ahalmen aerobikoa hobetzea, VO 2pikoa hobetzea, ezker bentrikuluaren eiekzio frakzioa handitzea ... Gainera, entrenamendu aerobikoaz gain, indar entrenamenduak, arnasketa entrenamenduak eta malgutasun entrenamenduak ere onura adierazgarriak lortzen dituztela frogatu da, entrenamendu mota hauek entrenamendu aerobikoaren konplimentagarri izan behar direlarik.

Serie Vídeos tutoriales para fonética. Video 3. Grabación (Parte III: Grabadoras)

Esta es una colección de 10 vídeos tutoriales que pueden ser empleados como material educativo en los cursos de fonética básica en el ámbito universitario. Los vídeos 1-3 tratan aspectos relacionados con la grabación: el tipo de micrófonos que se emplean, las clases de espacios en las que se suelen llevar a cabo la captura de señales de audio y las grabadoras que se suelen emplear. El vídeo 4 explora técnicas de captura y observación de datos de flujo y presión en fonética aerodinámica. Los vídeos 5-10 presentan información sobre los principales usos que se le brindan al programa Praat (Boersma y Weenink, 2014) en los estudios actuales de fonética acústica, desde la clase de información sobre modos de articulación de las consonantes que se puede identificar en oscilogramas hasta la creación de señales sonoras sintetizadas por medio de unos procedimientos que tiene el programa para tal propósito, los cuales son susceptibles de ser empleados en experimentos de percepción auditiva.