Design,optimization and in vivo evaluation of non-viral vectors for gene therapy. Applications in ocular disorders

227 págs.

Query-by-Example Spoken Term Detection ALBAYZIN 2012 evaluation: overview, systems, results, and discussion

Query-by-Example Spoken Term Detection (QbE STD) aims at retrieving data from a speech data repository given an acoustic query containing the term of interest as input. Nowadays, it has been receiving much interest due to the high volume of information stored in audio or audiovisual format. QbE STD differs from automatic speech recognition (ASR) and keyword spotting (KWS)/spoken term detection (STD) since ASR is interested in all the terms/words that appear in the speech signal and KWS/STD relies on a textual transcription of the search term to retrieve the speech data. This paper presents the systems submitted to the ALBAYZIN 2012 QbE STD evaluation held as a part of ALBAYZIN 2012 evaluation campaign within the context of the IberSPEECH 2012 Conference(a). The evaluation consists of retrieving the speech files that contain the input queries, indicating their start and end timestamps within the appropriate speech file. Evaluation is conducted on a Spanish spontaneous speech database containing a set of talks from MAVIR workshops(b), which amount at about 7 h of speech in total. We present the database metric systems submitted along with all results and some discussion. Four different research groups took part in the evaluation. Evaluation results show the difficulty of this task and the limited performance indicates there is still a lot of room for improvement. The best result is achieved by a dynamic time warping-based search over Gaussian posteriorgrams/posterior phoneme probabilities. This paper also compares the systems aiming at establishing the best technique dealing with that difficult task and looking for defining promising directions for this relatively novel task.

Modelado y control de estación de célula de manipulación

[ES]El objetivo de este proyecto es el diseño e implementación del modelo de la estación FMS 201 (alimentación de la base) y el diseño e implementación del control de la estación. Esta estación pertenece a la serie FMS 200 (sistema didáctico modular de ensamblaje flexible) distribuido por la empresa SMC. Se dispone uno en el laboratorio de investigación del departamento de Ingeniería de Sistemas y Automática de la Escuela Superior de Ingeniería de Bilbao (EHU/UPV). Para el desarrollo e implementación del modelo se usará la herramienta informática Automation Studio. Para el control del modelo se usará el PLC. Para el intercambio de información entre modelo y controlador se utilizará la comunicación OPC Para el control de la estación se usa un PLC S7-300 de la marca SIEMENS. Se finaliza el documento realizando las pruebas de validación del modelo desarrollado, ejecutándose el programa de control en el PLC y corriendo el modelo desarrollado en el PC.

Parity-dependent State Engineering and Tomography in the ultrastrong coupling regime

Reaching the strong coupling regime of light-matter interaction has led to an impressive development in fundamental quantum physics and applications to quantum information processing. Latests advances in different quantum technologies, like superconducting circuits or semiconductor quantum wells, show that the ultrastrong coupling regime (USC) can also be achieved, where novel physical phenomena and potential computational benefits have been predicted. Nevertheless, the lack of effective decoupling mechanism in this regime has so far hindered control and measurement processes. Here, we propose a method based on parity symmetry conservation that allows for the generation and reconstruction of arbitrary states in the ultrastrong coupling regime of light-matter interactions. Our protocol requires minimal external resources by making use of the coupling between the USC system and an ancillary two-level quantum system.

Stability analysis and observer design for discrete-time SEIR epidemic models

This paper applies Micken's discretization method to obtain a discrete-time SEIR epidemic model. The positivity of the model along with the existence and stability of equilibrium points is discussed for the discrete-time case. Afterwards, the design of a state observer for this discrete-time SEIR epidemic model is tackled. The analysis of the model along with the observer design is faced in an implicit way instead of obtaining first an explicit formulation of the system which is the novelty of the presented approach. Moreover, some sufficient conditions to ensure the asymptotic stability of the observer are provided in terms of a matrix inequality that can be cast in the form of a LMI. The feasibility of the matrix inequality is proved, while some simulation examples show the operation and usefulness of the observer.

Análisis Dinámico de mecanismos paralelos con requisitos de diseño mecatrónico

[ES]El objetivo del presente TFG es el Análisis Dinámico de mecanismos paralelos según las necesidades de la mecatrónica. La mecatrónica requiere expresiones explícitas de las fuerzas motoras que sólo dependen de las propias posiciones, velocidades y aceleraciones en los accionamientos. Ello requiere métodos avanzados de la mecánica analítica de sólido rígido. Concretamente se han desarrollado la ecuación de Lagrange modificada (según [11]) y la ecuación de Boltzmann-Hamel modificada, siendo esta última una aportación de este TFG. Como aplicación práctica se ha programado un modelo mecatrónico para un manipulador paralelo 5R y se ha optimizado el diseño de una Multi Axis Simulation Table 3PRS.