Discursos forales y fiscalidad real. Las provincias vascas ante el "crecimiento" de la sal de 1631

[ES]La sustitución de los millones por el crecimiento en el precio de la sal que Felipe IV estableció en 1631 provocó reacciones generalizadas en toda Castilla, y en particular entre las provincias que se hallaban exentas de pagarlos. Son conocidos los violentos disturbios de Vizcaya. En cambio, poco se sabe acerca de lo sucedido en las otras dos Provincias Exentas. El presente artículo analiza, en conjunto, la actitud que tanto Vizcaya como Guipúzcoa y Álava adoptaron ante el nuevo impuesto. Aunque las tres coincidieron en rechazarlo, lo hicieron mediante discursos y métodos bien diferentes. No en vano, lejos de lo que suele pensarse no gozaban de una plena equiparación fiscal ni jurídica.

Del arte en el espacio público: habitar/transitar (¿ser/estar?)

Ponencia leída en el Foro de Comunicaciones IkasArt II (BEC Barakaldo, 2010.06.17)

ColeccionApp

Aplicación móvil para iOS. Gestor de colecciones de cromos.

Ganadores del certamen literario de Ciencia Ficción Alberto Magno 2007-2010

La traición de Judas (Joaquín Revuelta Candón, 15ª edición 2003: 1er Premio). - Lemmings (Ignacio Sanz Vallas, 15ª edición 2003: 2º Premio) - Mar de Titanes (José Manuel González Rodríguez, 15ª edición 2003: Premio UPV). - No habrá vergüenza en mi derrota (Juan Luis López Aranguren, 16ª edición 2004: 1er Premio). - Sobre los inmortales (Ezequiel Dellutri, 16ª edición 2004: 2º Premio). - Tximeleta mezularia (Gotzone Barandika, 16ª edición 2004: Premio UPV). - Argos (José Antonio Cotrina Gómez, 17ª edición 2005: 1er Premio). - Las lágrimas de Caín (Juan Luis López Aranguren, 17ª edición 2005: 2º Premio). - Las dudas de Job (José Manuel González Rodríguez, 17ª edición 2005: Premio UPV). - Una larga descendencia (Santiago García Albás, 18ª edición 2006: 1er Premio). - La apuesta faustiana (Vladimir Hernández Pacín, 18ª edición 2006: 2º Premio)

Perinatal hipoxic ischemic injury in the auditory pathway and the effect of several neuroprotective agents

192 p.

Effect of Neonatal Asphyxia on the Impairment of the Auditory Pathway by Recording Auditory Brainstem Responses in Newborn Piglets: A New Experimentation Model to Study the Perinatal Hypoxic-Ischemic Damage on the Auditory Syste

Introduction Hypoxia-ischemia (HI) is a major perinatal problem that results in severe damage to the brain impairing the normal development of the auditory system. The purpose of the present study is to study the effect of perinatal asphyxia on the auditory pathway by recording auditory brain responses in a novel animal experimentation model in newborn piglets. Method Hypoxia-ischemia was induced to 1.3 day-old piglets by clamping 30 minutes both carotid arteries by vascular occluders and lowering the fraction of inspired oxygen. We compared the Auditory Brain Responses (ABRs) of newborn piglets exposed to acute hypoxia/ischemia (n = 6) and a control group with no such exposure (n = 10). ABRs were recorded for both ears before the start of the experiment (baseline), after 30 minutes of HI injury, and every 30 minutes during 6 h after the HI injury. Results Auditory brain responses were altered during the hypoxic-ischemic insult but recovered 30-60 minutes later. Hypoxia/ischemia seemed to induce auditory functional damage by increasing I-V latencies and decreasing wave I, III and V amplitudes, although differences were not significant. Conclusion The described experimental model of hypoxia-ischemia in newborn piglets may be useful for studying the effect of perinatal asphyxia on the impairment of the auditory pathway.

Pretreatment with Resveratrol Prevents Neuronal Injury and Cognitive Deficits Induced by Perinatal Hypoxia-Ischemia in Rats

Despite advances in neonatal care, hypoxic-ischemic brain injury is still a serious clinical problem, which is responsible for many cases of perinatal mortality, cerebral palsy, motor impairment and cognitive deficits. Resveratrol, a natural polyphenol with important anti-oxidant and anti-inflammatory properties, is present in grapevines, peanuts and pomegranates. The aim of the present work was to evaluate the possible neuroprotective effect of resveratrol when administered before or immediately after a hypoxic-ischemic brain event in neonatal rats by analyzing brain damage, the mitochondrial status and long-term cognitive impairment. Our results indicate that pretreatment with resveratrol protects against brain damage, reducing infarct volume, preserving myelination and minimizing the astroglial reactive response. Moreover its neuroprotective effect was found to be long lasting, as behavioral outcomes were significantly improved at adulthood. We speculate that one of the mechanisms for this neuroprotection may be related to the maintenance of the mitochondrial inner membrane integrity and potential, and to the reduction of reactive oxygen species. Curiously, none of these protective features was observed when resveratrol was administered immediately after hypoxia-ischemia.