Simple Coalitional Strategy Profiles in Repeated Games

This paper is a version of the discussion paper titled "Simple coalitional strategy profiles"

Strategic Behavior and Collusion: An Application to the Spanish Electricity Market

The paper has two major contributions to the theory of repeated games. First, we build a supergame oligopoly model where firms compete in supply functions, we show how collusion sustainability is affected by the presence of a convex cost function, the magnitude of both the slope of demand market, and the number of rivals. Then, we compare the results with those of the traditional Cournot reversion under the same structural characteristics. We find how depending on the number of firms and the slope of the linear demand, collusion sustainability is easier under supply function than under Cournot competition. The conclusions of the models are simulated with data from the Spanish wholesale electricity market to predict lower bounds of the discount factors.

Aproximación teórica de la lealtad de marca: enfoques y valoraciones

[ES] El concepto de lealtad no es nuevo en el mercadeo, por el contrario ha sido uno de los temas más investigados, sin embargo no se ha llegado a unificar criterios sobre su definición por ser un fenómeno complejo. Inicialmente, el estudio de la lealtad se abordó desde dos corrientes diferentes: como una actitud, donde se dan cabida sentimientos y afectos positivos a favor de una marca; como un comportamiento efectivo, materializado en compras repetidas de la misma marca. Luego, se consideró una corriente que plantea que la medición de la lealtad no concierne exclusivamente a la valoración del comportamiento de recompra o al compromiso, sino a ambos. El objetivo de este artículo es el describir los aspectos más relevantes del concepto de lealtad de marca, a partir de la revisión y análisis teórico, específicamente su definición, enfoques, métodos de medición y tipos, para presentar algunas consideraciones finales.

Role of Monoubiquitylation on the Control of IκBα Degradation and NF-κB Activity

9 p.

The Loss of Functional Caspase-12 in Europe Is a Pre-Neolithic Event

6 p.

Unidades organizativas indígenas del área indoeuropea de Hispania III: addenda

[ES] Se ofrecen los nuevos nombres, repetidos o no, de unidades organizativas indígenas (cognationes, gentes y gentilitates) aparecidos desde la década de los 90 del pasado siglo y documentados en la epigrafía latina y celtibérica de la Hispania indoeuropea

Validation of a Spanish version of the Revised Fibromyalgia Impact Questionnaire (FIQR)

8 p.

Molecular diagnosis of distal renal tubular acidosis in Tunisian patients: proposed algorithm for Northern Africa populations for the ATP6V1B1, ATP6V0A4 and SCL4A1 genes

Background: Primary distal renal tubular acidosis (dRTA) caused by mutations in the genes that codify for the H+ -ATPase pump subunits is a heterogeneous disease with a poor phenotype-genotype correlation. Up to now, large cohorts of dRTA Tunisian patients have not been analyzed, and molecular defects may differ from those described in other ethnicities. We aim to identify molecular defects present in the ATP6V1B1, ATP6V0A4 and SLC4A1 genes in a Tunisian cohort, according to the following algorithm: first, ATP6V1B1 gene analysis in dRTA patients with sensorineural hearing loss (SNHL) or unknown hearing status. Afterwards, ATP6V0A4 gene study in dRTA patients with normal hearing, and in those without any structural mutation in the ATP6V1B1 gene despite presenting SNHL. Finally, analysis of the SLC4A1 gene in those patients with a negative result for the previous studies. Methods: 25 children (19 boys) with dRTA from 20 families of Tunisian origin were studied. DNAs were extracted by the standard phenol/chloroform method. Molecular analysis was performed by PCR amplification and direct sequencing. Results: In the index cases, ATP6V1B1 gene screening resulted in a mutation detection rate of 81.25%, which increased up to 95% after ATP6V0A4 gene analysis. Three ATP6V1B1 mutations were observed: one frameshift mutation (c.1155dupC; p.Ile386fs), in exon 12; a G to C single nucleotide substitution, on the acceptor splicing site (c.175-1G > C; p.?) in intron 2, and one novel missense mutation (c. 1102G > A; p. Glu368Lys), in exon 11. We also report four mutations in the ATP6V0A4 gene: one single nucleotide deletion in exon 13 (c.1221delG; p. Met408Cysfs* 10); the nonsense c.16C > T; p.Arg6*, in exon 3; and the missense changes c.1739 T > C; p.Met580Thr, in exon 17 and c.2035G > T; p.Asp679Tyr, in exon 19. Conclusion: Molecular diagnosis of ATP6V1B1 and ATP6V0A4 genes was performed in a large Tunisian cohort with dRTA. We identified three different ATP6V1B1 and four different ATP6V0A4 mutations in 25 Tunisian children. One of them, c.1102G > A; p.Glu368Lys in the ATP6V1B1 gene, had not previously been described. Among deaf since childhood patients, 75% had the ATP6V1B1 gene c. 1155dupC mutation in homozygosis. Based on the results, we propose a new diagnostic strategy to facilitate the genetic testing in North Africans with dRTA and SNHL.

Influence of Humidity on Fiber Bragg Grating Sensors

We demonstrate the influence of the relative humidity (RH) on the wavelength of fiber Bragg grating sensors (FBGS), performing tests with five FBGS at different humidity and temperature conditions. These tests were performed in a climate chamber whose RH changes according to a scheduled profile from 30% to 90%, in steps of 10%. These profiles were repeated for a wide range of temperatures from to , in steps of . Two different types of instrumentation methods have been tested, spot welding and epoxy bonding, in two different materials, steel and carbon fiber reinforced polymer (CFRP). We discuss the results for each type of sensor and instrumentation method by analyzing the linearity of the Bragg wavelength with RH and temperature.

Randomised, crossover clinical trial, in healthy volunteers, to compare the systemic availability of two topical intranasal budesonide formulations

Background: Budesonide has a long history as intranasal drug, with many marketed products. Efforts should be made to demonstrate the therapeutic equivalence and safety comparability between them. Given that systemic availability significantly varies from formulations, the clinical comparability of diverse products comes to be of clinical interest and a regulatory requirement. The aim of the present study was to compare the systemic availability, pharmacodynamic effect, and safety of two intranasal budesonide formulations for the treatment of rhinitis. Methods: Eighteen healthy volunteers participated in this randomised, controlled, crossover, clinical trial. On two separated days, subjects received a single dose of 512 mu g budesonide (4 puffs per nostril) from each of the assayed devices (Budesonida nasal 64 (R), Aldo-Union, Spain and Rhinocort 64 (R), AstraZeneca, Spain). Budesonide availability was determined by the measurement of budesonide plasma concentration. The pharmacodynamic effect on the hypothalamic-adrenal axis was evaluated as both plasma and urine cortisol levels. Adverse events were tabulated and described. Budesonide availability between formulations was compared by the calculation of 90% CI intervals of the ratios of the main pharmacokinetic parameters describing budesonide bioavailability. Plasma cortisol concentration-time curves were compared by means of a GLM for Repeated Measures. Urine cortisol excretion between formulations was compared through the Wilcoxon's test. Results: All the enroled volunteers successfully completed the study. Pharmacokinetic parameters were comparable in terms of AUC(t) (2.6 +/- 1.5 vs 2.2 +/- 0.7), AUCi (2.9 +/- 1.5 vs 2.4 +/- 0.7), t(max) (0.4 +/- 0.1 vs 0.4 +/- 0.2), C(max)/AUC(i) (0.3 +/- 0.1 vs 0.3 +/- 0.0), and MRT (5.0 +/- 1.4 vs 4.5 +/- 0.6), but not in the case of C(max) (0.9 +/- 0.3 vs 0.7 +/- 0.2) and t(1/2) (3.7 +/- 1.8 vs 2.9 +/- 0.4). The pharmacodynamic effects, measured as the effect over plasma and urine cortisol, were also comparables between both formulations. No severe adverse events were reported and tolerance was comparable between formulations. Conclusion: The systemic availability of intranasal budesonide was comparable for both formulations in terms of most pharmacokinetic parameters. The pharmacodynamic effect on hypothalamic-pituitary-adrenal axis was also similar. Side effects were scarce and equivalent between the two products. This methodology to compare different budesonide-containing devices is reliable and easy to perform, and should be recommended for similar products intented to be marketed or already on the market.

Fiabilidad de diferentes pruebas que se utilizan para evaluar el riesgo de lesión del miembro inferior en mujeres deportistas

233 p. : il. + anexo (247 p.)

Annotation of orthologous genes in Tunnus thynnus and T.albacore species

Albacore and Atlantic Bluefin tuna are two pelagic fish. Atlantic Bluefin tuna is included in the IUCN red list of threatened species and albacore is considered to be near threatened, so conservation plans are needed. However, no genomic resources are available for any of them. In this study, to better understand their transcriptome we functionally annotated orthologous genes. In all, 159 SNPs distributed in 120 contigs of the muscle transcriptome were analyzed. Genes were predicted for 98 contigs (81.2%) using the bioinformatics tool BLAST. In addition, another bioinformatics tool, BLAST2GO was used in order to achieve GO terms for the genes, in which 41 sequences were given a biological process, and 39 sequences were given a molecular process. The most repeated biological process was metabolism and it is important that no cellular process was given in any of the sequences. The most abundant molecular process was binding and very few catalytic activity processes were given. From the initial 159 SNPs, 40 were aligned with a sequence in the database after BLAST2GO was run, and were polymorphic in Atlantic Bluefin tuna and monomorphic in albacore. From these 40 SNPs, 24 were located in an open reading frame of which four were non-synonymous and 20 were synonymous and 16 were not located in a known open reading frame,. This study provides information for better understanding the ecology and evolution of these species and this is important in order to establish a proper conservation plan and an appropriate management.

Bertso transformation with pattern-based sampling

This paper presents a method to generate new melodies, based on conserving the semiotic structure of a template piece. A pattern discovery algorithm is applied to a template piece to extract significant segments: those that are repeated and those that are transposed in the piece. Two strategies are combined to describe the semiotic coherence structure of the template piece: inter-segment coherence and intra-segment coherence. Once the structure is described it is used as a template for new musical content that is generated using a statistical model created from a corpus of bertso melodies and iteratively improved using a stochastic optimization method. Results show that the method presented here effectively describes a coherence structure of a piece by discovering repetition and transposition relations between segments, and also by representing the relations among notes within the segments. For bertso generation the method correctly conserves all intra and inter-segment coherence of the template, and the optimization method produces coherent generated melodies.

Evaluation of a programme to improve emotional intelligence during adolescence

348 p.

El cerebro como regulador del rendimiento en la capacidad de repetir sprints

[ES] Durante pruebas cíclicas de larga duración ha sido probada que las estrategias para gestionar la fatiga pueden ser un factor determinante. A pesar de ello, este mismo fenómeno no está del todo probado que pueda darse en esfuerzos máximos de corta duración. Es por eso, que el objetivo de este trabajo ha sido analizar si variando el grado de conocimiento de los atletas durante este tipo de pruebas puede darse alguna alteración en su rendimiento. METODO: Siete deportistas varones completaron durante tres diferentes días un mismo protocolo (8 repeticiones máximas de 30 metros con un minuto de recuperación) en el que se varió la información que se les deba. Así, el primer día se les señaló que realizarían 4 repeticiones, pero cuando finalizaron se les indicó que realizarían 4 más (Prueba decepción). El segundo día, no se les informó del número de repeticiones a realizar (Prueba Suspense) y se les mandó parar al realizar la octava. Y por último, el tercer día se les señaló que realizarían 8 repeticiones (Prueba Control). RESULTADOS: Diferencias significativas (p>0.05) se encontraron en los tiempos de las cuatro primeras repeticiones entre la Prueba Suspense y Prueba Decepción. CONCLUSIÓN: Los resultados muestran como en pruebas máximas de corta duración las estrategias de gestión de la fatiga se pueden dar de manera anticipatoria al número de repeticiones a realizar.