Goierriko garraioaren hobekuntza eta ingurumen inpaktua

[EU]Goierriko eskualdean egun batean burutzen diren bidai guztien %9a bakarrik burutzen da garraio publiko bidez. Hau gertatzearen bizilagunen “aitzakia” nagusia honakoa da: zerbitzua oso txarra da. Niri ordea, ondorengo zalantza datorkit burura: nahiz eta zerbitzua hobea izan, garraio publikoa gehiago erabiliko litzateke? Hau biraka dabilen gurpil zoroa da. Zerbitzua txarra delako ez dabil jende gehiago, baina ez du merezi zerbitzua hobetzea jende gutxi ibiltzen delako. Guzti hau argitzearren eta Goierriko garraio publikoaren hobekuntza sustatzeko zer egin daitekeen aztertzeko garatu da lan hau. Hobekuntza termino hau autobus gehiago jartzearekin erlazionatzen dugu gehienetan, baina nik beste planteamendu bat eman nahi izan diot. Bidaiari gutxi daudenez, ezin dira maiztasun handiz autobusak ezarri, proiektua ez baita bideragarria. Horregatik dagoen zerbitzua, gutxi bada ere, bizilagunei erabat moldatua egotea mahaigaineratu nahi izan dut, bizilagun hauen sentsibilizazioari arreta berezia eskainiz.

Guided Bus Rapid Transit

Electrical Bus Rapid Transit (eBRT) is a charging electrical public transport which brings a clean, high performance, and affordable cost alternative from the conventional traffic vehicles which work with combustion and hybrid technology. These buses charge the battery in every bus stop to arrive at the next station. But, this charging system needs an appropriate infrastructure called pantograph, and it requires a high precision bus location to maintain battery lifetime, energy saving and charging time. To overcome this issue Vicomtech and Datik has planned a project based on computer vision to help to the driver to locate the vehicle in the correct place. In this document, we present a mono camera bus driver guided fast algorithm because these vehicles embedded computers do not support high computation and precision operations. In addition to the frequent lane sign, there are more accurate geometric beacons painted on the road to bring metric information to the vision system. This method uses segmentation to binarize the image discriminating the background space. Besides it detects, tracks and counts different lane mark contours in addition to classify each special painted mark. Besides it does not need any calibration task to calculate longitudinal and cross distances because we know the lane mark sizes.

Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport

Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia (AML), where mutant NPM seems to play an oncogenic role. AML-associated NPM mutants exhibit altered subcellular traffic, being aberrantly located in the cytoplasm of leukoblasts. Exacerbated export of AML variants of NPM is mediated by the nuclear export receptor CRM1, and due, in part, to a mutationally acquired novel nuclear export signal (NES). To gain insight on the molecular basis of NPM transport in physiological and pathological conditions, we have evaluated the export efficiency of NPM in cells, and present new data indicating that, in normal conditions, wild type NPM is weakly exported by CRM1. On the other hand, we have found that AML-associated NPM mutants efficiently form complexes with CRM1HA (a mutant CRM1 with higher affinity for NESs), and we have quantitatively analyzed CRM1HA interaction with the NES motifs of these mutants, using fluorescence anisotropy and isothermal titration calorimetry. We have observed that the affinity of CRM1HA for these NESs is similar, which may help to explain the transport properties of the mutants. We also describe NPM recognition by the import machinery. Our combined cellular and biophysical studies shed further light on the determinants of NPM traffic, and how it is dramatically altered by AML-related mutations.

What Can the Brain Teach Us about Winemaking? An fMRI Study of Alcohol Level Preferences

Over the last few decades, wine makers have been producing wines with a higher alcohol content, assuming that they are more appreciated by consumers. To test this hypothesis, we used functional magnetic imaging to compare reactions of human subjects to different types of wine, focusing on brain regions critical for flavor processing and food reward. Participants were presented with carefully matched pairs of high- and low- alcohol content red wines, without informing them of any of the wine attributes. Contrary to expectation, significantly greater activation was found for low- alcohol than for high- alcohol content wines in brain regions that are sensitive to taste intensity, including the insula as well as the cerebellum. Wines were closely matched for all physical attributes except for alcohol content, thus we interpret the preferential response to the low- alcohol content wines as arising from top-down modulation due to the low alcohol content wines inducing greater attentional exploration of aromas and flavours. The findings raise intriguing possibilities for objectively testing hypotheses regarding methods of producing a highly complex product such as wine.