9 resultados para Predicting future earnings growth
em Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco
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El objetivo del presente trabajo es el de establecer las directrices de una valoración actuarial en los diversos casos en los que puede ser requerido en caso de litigio e intentar tras realizar una lectura completa de este trabajo tener una visión más cercana y comprensible de lo que al principio podría verse como algo fuera del entendimiento de alguien sin una formación y conocimiento actuarial, sin embargo, con unos conocimientos actuariales básicos el objetivo es que sea sencillo y aporte una visión general de la valoración actuarial. Se compone de una parte teórica donde se define y se desglosan los factores del lucro cesante a tener en cuenta para la realización de su valoración, así mismo, se muestran distintas metodologías, y finalmente se encuentra la parte práctica donde se realizan varias hipótesis, todas ellas con su definición y detallándose su labor en la valoración; y un intervalo de supuestos prácticos que engloba los sucesos más comunes en la vida real. En definitiva, el objetivo del presente trabajo además de entender el procedimiento para la valoración del actuario es tras realizar una lectura completa del trabajo comprender la importancia del papel del actuario, al ser éste la persona encargada de lograr la justicia y equidad social, consiguiendo con sus conocimientos actuariales que aquella persona que se haya visto perjudicada económicamente por el suceso sea resarcida justamente.
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47 p.
Current Approaches for Predicting a Lack of Response to Anti-EGFR Therapy in KRAS Wild-Type Patients
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Targeting epidermal growth factor receptor (EGFR) has been one of the most effective colorectal cancer strategies. Anti-EGFR antibodies function by binding to the extracellular domain of EGFR, preventing its activation, and ultimately providing clinical benefit. KRAS mutations in codons 12 and 13 are recognized prognostic and predictive biomarkers that should be analyzed at the clinic prior to the administration of anti-EGFR therapy. However, still an important fraction of KRAS wild-type patients do not respond to the treatment. The identification of additional genetic determinants of primary or secondary resistance to EGFR targeted therapy for further improving the selection of patients is urgent. Herein, we review the latest published literature highlighting the most important genes that may predict resistance to anti-EGFR monoclonal antibodies in colorectal cancer patients. According to the available findings, the evaluation of BRAF, NRAS, PIK3CA, and PTEN status could be the right strategy to select patients who are likely to respond to anti-EGFR therapies. In the future, the combination of those biomarkers will help establish consensus that can be introduced into clinical practice.
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In this paper we analyze the effects of social security policies in an unfunded, earnings-related social security system on the incentives to education investment and voluntary retirement, on growth and on income inequality. Growth is endogenously driven by human capital investment, individuals differ in their innate (learning) ability at birth, and the pension scheme includes a minimum pension. More skilled individuals spend more on education, minimum pensions reduce low skill individuals' incentives to invest in human capital, there is no monotonic relationship between per capita growth and income inequality.
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4 p.
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20 p.
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29 p.
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9 p.
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This paper analyzes the effects of personal income tax progressivity on long-run economic growth, income inequality and social welfare. The quantitative implications of income tax progressivity increments are illustrated for the US economy under three main headings: individual effects (reduced labor supply and savings, and increased dispersion of tax rates); aggregate effects (lower GDP growth and lower income inequality); and welfare effects (lower dispersion of consumption across individuals and higher leisure levels, but also lower growth of future consumption). The social discount factor proves to be crucial for this third effect: a higher valuation of future generations' well-being requires a lower level of progressivity. Additionally, if tax revenues are used to provide a public good rather than just being discarded, a higher private valuation of such public goods will also call for a lower level of progressivity.