Los programas de fidelización como plataforma de venta directa: clasificación de los titulares según la redención de billetes aéreos

[ES] Cada vez son más numerosos los programas de fidelización que ofrecen al titular la posibilidad de comprar puntos o conseguir premios, viajes o billetes aéreos pagando una parte de los mismos con dinero. Dicha característica, unida a la propia estructura y dinámica de los programas de fidelización y a la actual coyuntura del sector turístico, ha permitido desarrollar plataformas de venta directa desde las que ofrecer servicios a los titulares.

Ahozkotasunaren irakaskuntza bigarren hezkuntzako testuliburuetan

[EN]Traditionally writing skills have been given priority in language teaching and so, oral skills have been put aside. However, during the last years many voices have asserted the importance of oral skills. Therefore, they claim that oral language teaching must be emphasized at school. Also, the necessity of strengthening oral language is shown in the new curriculum. Nevertheless, those intentions are reflected in very different ways in textbooks. In this work we have looked into the treatment that oral language is given in teaching materials because, in our opinion, textbooks are one of the most important tools for teachers. The facts show that the importance given to oral language and the exercises and tools needed to work that skill are very different from one publishing house to another. Besides, we have confirmed that all the textbooks don’t satisfy the requirements proposed in the Basque official curriculum (e.g. didactic sequences) or that the approach to the text or the way to work with it are not always what they should be. Therefore, it is obvious that we have still a long way in the field of oral language and specially in the way of teaching oral skills

Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial

Background The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a humanized monoclonal antibody that recognizes the EGFR extracellular domain and reaches Central Nervous System tumors, in nonclinical and clinical setting. While it has similar activity when compared to other anti-EGFR antibodies, it does not induce skin toxicity or hypomagnesemia. Methods A randomized, double blind, multicentric clinical trial was conducted in high grade glioma patients (41 anaplastic astrocytoma and 29 glioblastoma multiforme) that received radiotherapy plus nimotuzumab or placebo. Treatment and placebo groups were well-balanced for the most important prognostic variables. Patients received 6 weekly doses of 200 mg nimotuzumab or placebo together with irradiation as induction therapy. Maintenance treatment was given for 1 year with subsequent doses administered every 3 weeks. The objectives of this study were to assess the comparative overall survival, progression free survival, response rate, immunogenicity and safety. Results The median cumulative dose was 3200 mg of nimotuzumab given over a median number of 16 doses. The combination of nimotuzumab and RT was well-tolerated. The most prevalent related adverse reactions included nausea, fever, tremors, anorexia and hepatic test alteration. No anti-idiotypic response was detected, confirming the antibody low immunogenicity. The mean and median survival time for subjects treated with nimotuzumab was 31.06 and 17.76 vs. 21.07 and 12.63 months for the control group. Conclusions In this randomized trial, nimotuzumab showed an excellent safety profile and significant survival benefit in combination with irradiation.

Anoak estimatzerakoan doitasun maila: elikagaien formek duten eragina

[EUS] Ikerketa lan honen helburua entrenamendu programa baten ondoren elikagaien formek, anoak estimatzeko garaian duen eragina baloratzea da. Doitasun baxuenarekin estimaturiko elikagai amorfoak izan ziren, bai entrenamendu aurretik zein ondoren. Estimazioan eginiko akatsak txikitu egin ziren entrenamenduaren ondoren elikagai solido eta likidoetan, nahiz eta hilabete batzuk igaro ondoren akats hauek areagotu.

Criterios para la aplicación de coeficientes modificativos de la curva S-N de fatiga

[ES]Este Trabajo de Fin de Grado tiene como objeto crear un programa que sirva como herramienta para los cálculos en las propiedades a fatiga de una pieza. El conjunto del trabajo se centra en su creación mediante la herramienta Excel. El programa cuenta con tres diferentes pestañas: una para los datos que debe introducir el usuario, otra correspondiente a los cálculos y por último una en la que aparecen los resultados. El usuario debe conocer las propiedades de la probeta del material a ensayar, así como el rango de ciclos en el cual se va a trabajar (siempre en un rango de ciclos medio alto). A partir de estas informaciones de la probeta, y gracias a la curva de Basquin y la ecuación de Marin, el programa será capaz de obtener la curva de resistencia a fatiga correspondiente para la pieza. Se incluyen también casos especiales en los que se realicen tratamientos mecánicos de mejora, con una tensión límite del proceso. Para obtener la curva S-N de la pieza se pedirá información en la pestaña de interfaz con el usuario sobre distintas propiedades de la pieza, que permitan así calcular los valores de los coeficientes de Marín gracias a la base de datos que contiene el programa. El usuario tiene también la opción de introducir él mismo los valores de los coeficientes para así obtener una curva que se aproxime más a sus resultados experimentales. En resumen, la función del programa es la de ser una calculadora de la resistencia fatiga de la pieza a partir de los datos que se disponen de la probeta.

Evaluation of a programme to improve emotional intelligence during adolescence

348 p.

Effectiveness of a Multi-Component Smoking Cessation Support Programme (McSCSP) for Patients with Severe Mental Disorders: Study Design

Only a few studies have examined the efficacy and safety of smoking cessation programmes in patients with mental disorders. The aim of this paper is to describe in detail the methodology used in the study as well as the Multi-component Smoking Cessation Support Programme in terms of pharmacological treatments and psychological interventions. An open-label 9-month follow-up study was conducted in Spain. A total of 82 clinically stable outpatients with schizophrenia, schizoaffective or bipolar disorder were enrolled. Treatment consisted of a programme specifically developed by the research team for individuals with severe mental disorders. The programme consisted of two phases: (1) weekly individual motivational therapy for 4-12 weeks, and (2) a 12-week active treatment phase. During this phase, at each study visit patients received a one- or two-week supply of medication (transdermal nicotine patches, varenicline or bupropion) with instructions on how to take it, in addition to group psychotherapy for smoking cessation. Evaluations were performed: (1) at the time of enrolment in the study, (2) during the 12-week active treatment phase of the study (weekly for the first 4 weeks and then biweekly), and (3) after the end of this phase (two follow-up assessments at weeks 12 and 24). Evaluations included: (1) smoking history, (2) substance use, (3) psychopathology, (4) adverse events, and (5) laboratory tests. The importance of this study lies in addressing a topical issue often ignored by psychiatrists: the unacceptably high rates of tobacco use in patients with severe mental disorders.