Prediction of Multi-Target Networks of Neuroprotective Compounds with Entropy Indices and Synthesis, Assay, and Theoretical Study of New Asymmetric 1,2-Rasagiline Carbamates

In a multi-target complex network, the links (L-ij) represent the interactions between the drug (d(i)) and the target (t(j)), characterized by different experimental measures (K-i, K-m, IC50, etc.) obtained in pharmacological assays under diverse boundary conditions (c(j)). In this work, we handle Shannon entropy measures for developing a model encompassing a multi-target network of neuroprotective/neurotoxic compounds reported in the CHEMBL database. The model predicts correctly >8300 experimental outcomes with Accuracy, Specificity, and Sensitivity above 80%-90% on training and external validation series. Indeed, the model can calculate different outcomes for >30 experimental measures in >400 different experimental protocolsin relation with >150 molecular and cellular targets on 11 different organisms (including human). Hereafter, we reported by the first time the synthesis, characterization, and experimental assays of a new series of chiral 1,2-rasagiline carbamate derivatives not reported in previous works. The experimental tests included: (1) assay in absence of neurotoxic agents; (2) in the presence of glutamate; and (3) in the presence of H2O2. Lastly, we used the new Assessing Links with Moving Averages (ALMA)-entropy model to predict possible outcomes for the new compounds in a high number of pharmacological tests not carried out experimentally.

A neural extracellular matrix-based method for in vitro hippocampal neuron culture and dopaminergic differentiation of neural stem cells

Background: The ability to recreate an optimal cellular microenvironment is critical to understand neuronal behavior and functionality in vitro. An organized neural extracellular matrix (nECM) promotes neural cell adhesion, proliferation and differentiation. Here, we expanded previous observations on the ability of nECM to support in vitro neuronal differentiation, with the following goals: (i) to recreate complex neuronal networks of embryonic rat hippocampal cells, and (ii) to achieve improved levels of dopaminergic differentiation of subventricular zone (SVZ) neural progenitor cells. Methods: Hippocampal cells from E18 rat embryos were seeded on PLL- and nECM-coated substrates. Neurosphere cultures were prepared from the SVZ of P4-P7 rat pups, and differentiation of neurospheres assayed on PLL- and nECM-coated substrates. Results: When seeded on nECM-coated substrates, both hippocampal cells and SVZ progenitor cells showed neural expression patterns that were similar to their poly-L-lysine-seeded counterparts. However, nECM-based cultures of both hippocampal neurons and SVZ progenitor cells could be maintained for longer times as compared to poly-L-lysine-based cultures. As a result, nECM-based cultures gave rise to a more branched neurite arborization of hippocampal neurons. Interestingly, the prolonged differentiation time of SVZ progenitor cells in nECM allowed us to obtain a purer population of dopaminergic neurons. Conclusions: We conclude that nECM-based coating is an efficient substrate to culture neural cells at different stages of differentiation. In addition, neural ECM-coated substrates increased neuronal survival and neuronal differentiation efficiency as compared to cationic polymers such as poly-L-lysine.

Implications of governance structures on urban climate action: evidence from Italy and Spain

47 p.

Europeanization beyond the EU: The case of Georgia.

320 p.

Las Tecnologías de la Información y la Comunicación en la gestión de tesorería: modelo explicativo

[ES] En el presente trabajo se analiza el uso de las TIC (Tecnologías de la Información y la Comunicación) en las responsabilidades de la gestión de la tesorería, tomando como referencia para su estudio las empresas de la CAPV (Comunidad Autónoma del País Vasco). Los resultados indican que las TIC más utilizadas por las empresas en operaciones financieras son el software financiero, Internet y la banca electrónica. Además, estos resultados han permitido desarrollar un modelo explicativo del uso de las TIC en las principales funciones del tesorero, como son la gestión de cobros y pagos, gestión de la liquidez, previsiones de tesorería a corto plazo, gestión de saldos bancarios en fecha valor, negociación con entidades financieras, gestión de la financiación del déficit de tesorería, gestión de la colocación de puntas de tesorería y gestión de riesgos de tipo de interés y tipo de cambio.

Pertsonaia protagonista femeninoen ezaugarriak eta bilakaera euskal narratiba garaikidean

361 p.

MANAGEMENT: Historia y tendencias de la administración de empresas desde sus orígenes hasta el nuevo estilo de relaciones de Koldo Saratxaga.

[ES]Este trabajo presenta la evolución de la administración de empresas desde sus primeras manifestaciones y recopila las teorías y enfoques surgidos desde el siglo XIX hasta nuestros días, así como las últimas tendencias en este ámbito y el nuevo estilo de relaciones de Koldo Saratxaga.

The Spanish corporate structure through interlocking directorates

[EN] The aim of this paper is to determine to what extent globalization pressures are changing interlocking directorate networks modeled on continental capitalism into Anglo-Saxon models. For this purpose we analyse the Spanish network of interlocks, comparing the present structure (2012) with that of 1993 and 2006. We show how, although Spanish corporative structure continues to display characteristics of the continental economies, some major banks are significantly reducing industrial activity. Nevertheless, the financial organizations continue to maintain a close relationship with sectors such as construction and services. The analysis of the network of directorates shows a retreat in activity of industrial banking in Spain. Two large Spanish financial institutions, BSCH and La Caixa, continue to undertake activities of industrial banking in 2006, but this activity is significantly reduced in 2012. According to the theories on the role of the interlocking directorates, the companies in these sectors assure their access to banking credit by incorporating advisors from financial organizations to their board of directors. We cannot conclude that the structure of the Spanish corporate network has become a new case of Anglo-Saxon structure, but we got indications that are becoming less hierarchic as banks seem to slowly abandon centrality positions. This is especially salient if we compare the networks of 2006 and 2012, which show a continuing decrease of the role of banks and insurance companies in the network.

Bizi toki hezkuntza eredu eraldatzailea?

[eus] Haurra kapitalismoaren subjektu antagoniko gisa definituz, kapitalismoa eta eskolaren arteko lotura du abiapuntu gisa lan honek. Kapitalismoaren birprodukzio eta metaketarako beharrezkoa den eskola bi ikuspegitik aztertzen da. Alde batetik, kapitalismoaren osaketa arkitektonikotik. Bestetik, kapitalismoaren balore, ohitura eta erlazionatzeko forma hegemonikoen transmisiotik. Bi ildo teoriko horietan oinarrituta, ikerketa lan honen objektu nagusia zera da, jendarte post-kapitalista eraikitzen ari den Bizi Toki proiektua. Horretarako metodologia kualitatiboa erabili dugu; elkarrizketa erdi egituratua, behaketa eta dokumentuen analisia hain zuzen ere.

Dehydration for a solid coordination network based on CuII-(py)2C(OH)2 trimers

Abstract de congreso: Póster presentado en 12th International Conference on Materials Chemistry (MC12), 20 - 23 July 2015, York, United Kingdom