RCeveierwamide and ceramide 1-phosphate in health and disease

Sphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the promotion of cell cycle arrest and the induction of apoptosis. Phosphorylation of ceramide produces ceramide 1-phosphate (C1P), which has opposite effects to ceramide. C1P is mitogenic and has prosurvival properties. In addition, C1P is an important mediator of inflammatory responses, an action that takes place through stimulation of cytosolic phospholipase A2, and the subsequent release of arachidonic acid and prostaglandin formation. All of the former actions are thought to be mediated by intracellularly generated C1P. However, the recent observation that C1P stimulates macrophage chemotaxis implicates specific plasma membrane receptors that are coupled to Gi proteins. Hence, it can be concluded that C1P has dual actions in cells, as it can act as an intracellular second messenger to promote cell survival, or as an extracellular receptor agonist to stimulate cell migration.

Diseño e implementación de un taller de teatro musical en Educación Primaria

[SPA] Las disciplinas artísticas siempre han sido un campo tan beneficioso como poco utilizado en educación. En esta propuesta de taller de teatro musical en educación primaria se ha indagado en el mundo de la pedagogía teatral y su relación con la música y el juego como técnicas de transmisión de valores y desarrollo de aprendizajes. La puesta en práctica mediante el diseño e implementación de un taller por parte del mediador ha logrado que los alumnos muestren avances significativos en diversos campos como el autoconocimiento corporal o el descubrimiento de nuevos géneros musicales, además de favorecer a la dinámica grupal dentro y fuera del taller. De cara al futuro, este proceso ha abierto las puertas a nuevas propuestas en el ámbito de la dramatización infantil así como al interés formativo del propio educador.

The body social: an enactive approach to the self

This paper takes a new look at an old question: what is the human self? It offers a proposal for theorizing the self from an enactive perspective as an autonomous system that is constituted through interpersonal relations. It addresses a prevalent issue in the philosophy of cognitive science: the body-social problem. Embodied and social approaches to cognitive identity are in mutual tension. On the one hand, embodied cognitive science risks a new form of methodological individualism, implying a dichotomy not between the outside world of objects and the brain-bound individual but rather between body-bound individuals and the outside social world. On the other hand, approaches that emphasize the constitutive relevance of social interaction processes for cognitive identity run the risk of losing the individual in the interaction dynamics and of downplaying the role of embodiment. This paper adopts a middle way and outlines an enactive approach to individuation that is neither individualistic nor disembodied but integrates both approaches. Elaborating on Jonas' notion of needful freedom it outlines an enactive proposal to understanding the self as co-generated in interactions and relations with others. I argue that the human self is a social existence that is organized in terms of a back and forth between social distinction and participation processes. On this view, the body, rather than being identical with the social self, becomes its mediator

Kapital sozialaren garrantzia familia enpresetan

[EU]Kapital sozialaren ikuspegian oinarriturik eta kotizatu gabeko 172 familiaenpresa espainiarren lagin bat erabiliz, barne hartuz enpresan kudeaketa-funtzioak betetzen dituzten pertsona elkarrizketatu bi eta guztira 344 galdetegi izanik, uste dugu kapital sozial familiarrak bitartekari gisa balio duela kapital sozial ez-familiarraren eta enpresaren jardueraren artean. Gainera, gure emaitzek kapital sozialaren ulermena familia-enpresatik haratago hedatzen dute, erakundeek talde sozial nagusi baten presentzia ezaugarritzat duten testuinguru batean.