Nuevo sistema de propulsión naval

143 p.

Recopilación de artículos sobre la geografía vasca, y nota del "Diario de Navarra" sobre las investigaciones del profesor Angel Viñas sobre la Guerra Civil.

Fecha: 11-8-1972/9-5-1982 / Unidad de instalación: Carpeta 48 - Expediente 7-18 / Nº de pág.: 7 (mecanografiadas)

El ultimatum de María Jesús

Duración (en horas): Más de 50 horas. Destinatario: Estudiante y Docente

Carta enviada por Jesús Arpal Poblador a Justo Garate en 1978

1 carta (mecanografiada) ; 207x295mm. Ubicación: Caja 1 - Carpeta 54

Cartas enviadas por José Angel Ascunde a Justo Garate entre 1991 y 1994

9 cartas y 1 tarjeta de visita (mecanografiadas y manuscritas) ; 210x295mm. Ubicación: Caja 1 - Carpeta 70

Carta enviada por Angel Ayestarán a Justo Garate en 1982

1 carta (mecanografiada) ; 219x277mm. Ubicación: Caja 1 - Carpeta 78

Cartas enviadas por Jesús Basañez a Justo Garate en 1982

3 cartas (mecanografiadas) ; 215x280mm

Tarjeta enviada por Jesús Mª Bellido a Justo Garate en 1928

1 tarjeta (manuscrita) ; 140x90mm

Geology alive. GeoBizirik.org

Geology is the science that studies the Earth, its composition, structure and origin in addition to past and present phenomena that leave their mark on rocks. So why does society need geologists? Some of the main reasons are listed below: - Geologists compile and interpret information about the earth’s surface and subsoil, which allows us to establish the planet’s past history, any foreseeable changes and its relationship with the rest of the solar system. - Society needs natural resources (metals, non-metals, water and fossil fuels) to survive. The work of geologists is therefore a key part of finding new deposits and establishing a guide for exploring and managing resources in an environmentally-friendly way. - The creation of geological maps allows us to identify potential risk areas and survey different land uses; in other words, they make an essential contribution to land planning and proposing sustainable development strategies in a region. - Learning about Geology and the proper use of geological information contributes to saving lives and reducing financial loss caused by natural catastrophes such as earthquakes, tsunamis, volcanic eruptions, flooding and landslides, while also helping to develop construction projects, public works, etc. Through the proposed activities we aim to explain some of the basic elements of the different specialities within the field of Geological Sciences. In order to do this, four sessions have been organised that will allow for a quick insight into the fields of Palaeontology, Mineralogy, Petrology and Tectonics.

Geología en acción. GeoBizirik.org

La Geología es la ciencia que estudia la Tierra en su conjunto, su composición, estructura y origen, así como los fenómenos que han tenido lugar en el pasado o que se producen en la actualidad y que han dejado sus huellas en las rocas. Pero, ¿por qué necesita la sociedad a los geólogos? A continuación se citan algunas de las principales razones: - Los geólogos recopilan e interpretan información de la superficie terrestre y del subsuelo, lo que permite establecer la historia pasada del planeta, sus cambios previsibles y su relación con el resto del sistema solar. - La sociedad requiere para su subsistencia recursos naturales (metálicos, no metálicos, hídricos y combustibles fósiles). La labor de los geólogos es determinante para la localización de nuevos yacimientos y para establecer las guías de una explotación y gestión respetuosa con el medio ambiente. - La elaboración de cartografías geológicas permite identificar potenciales zonas de riesgo y acotar distintos usos del suelo; es decir, es esencial para la planificación del territorio y para proponer estrategias de desarrollo sostenible en una región. - La educación en Geología y el buen uso de la información geológica contribuye a salvar vidas y a reducir las pérdidas económicas originadas por catástrofes naturales tales como terremotos, tsunamis, erupciones volcánicas, inundaciones y desprendimientos, así como a desarrollar proyectos de construcción, obras públicas, etc. Con las actividades propuestas se pretende dar a conocer algunos aspectos básicos de distintas especialidades de las Ciencias Geológicas. Para ello se han organizado cuatro sesiones destinadas a realizar una pequeña inmersión en el campo de la Paleontología, la Mineralogía, la Petrología y la Tectónica.

Geology alive. GeoBizirik.org

Geology is the science that studies the Earth, its composition, structure and origin in addition to past and present phenomena that leave their mark on rocks. So why does society need geologists? Some of the main reasons are listed below: - Geologists compile and interpret information about the earth’s surface and subsoil, which allows us to establish the planet’s past history, any foreseeable changes and its relationship with the rest of the solar system. - Society needs natural resources (metals, non-metals, water and fossil fuels) to survive. The work of geologists is therefore a key part of finding new deposits and establishing a guide for exploring and managing resources in an environmentally-friendly way. - The creation of geological maps allows us to identify potential risk areas and survey different land uses; in other words, they make an essential contribution to land planning and proposing sustainable development strategies in a region. - Learning about Geology and the proper use of geological information contributes to saving lives and reducing financial loss caused by natural catastrophes such as earthquakes, tsunamis, volcanic eruptions, flooding and landslides, while also helping to develop construction projects, public works, etc. Through the proposed activities we aim to explain some of the basic elements of the different specialities within the field of Geological Sciences. In order to do this, four sessions have been organised that will allow for a quick insight into the fields of Palaeontology, Mineralogy, Petrology and Tectonics.

Geologia bizirik. GeoBizirik.org

Geologia Lurra aztertzen duen zientzia da: lurraren osaera, egitura eta jatorria, eta bai arroketan aztarnak utzi dituzten iraganeko edo gaur egungo gertaerak ere. Baina, zergatik du gizarteak geologoen beharra? Hona hemen zenbait arrazoi: - Geologoek lurrazalari eta lurpeari buruzko informazioa bildu, eta interpretatu egiten dute. Informazio horrek guztiak ahalbidetzen du planetaren iraganeko historia, Lurrean aurreikus daitezkeen aldaketak eta gure planetak Eguzki-sistemarekin duen harremana finkatzea. - Gizarteak beharrezkoak ditu baliabide naturalak (metalikoak, ez-metalikoak, ura eta erregai fosilak). Geologoen parte-hartzea erabakigarria da hobi berriak aurkitzeko eta ingurumena zaintzen duten baliabide naturalen ustiapen eta kudeaketarako irizpideak ezartzeko. - Kartografia geologikoen bidez arrisku-eremuak identifikatu eta lurzoruaren erabilerak mugatzen dira. Geologoak beharrezkoak dira, beraz, lurraldearen planifikaziorako eta garapen iraunkorrerako estrategiak garatzeko. - Geologiaren ezagutzak eta informazio geologikoaren erabilera egokiak laguntzen dute bizitzak salbatzen eta lurrikarak, tsunamiak, erupzio bolkanikoak, uholdeak eta lurjausiak bezalako katastrofe naturalek eragindako diru-galerak murrizten. Halaber laguntzen dute eraikuntza-proiektuak, herri-lanak eta abar garatzen ere. Proposatutako jardueren bitartez, Zientzia Geologikoen adar desberdinen oinarrizko zenbait alderdi ezagutzera eman nahi ditugu. Horretarako, lau saio antolatu ditugu Paleontologia, Mineralogia, Petrologia eta Tektonika arloetan murgiltzeko.

Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness

Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 (TSC1 or TSC2) genes. While allosteric inhibition of the mechanistic target of rapamycin (mTOR) has shown substantial clinical benefit, complementary therapies are required to improve response and/or to treat specific patients. However, there is a lack of LAM biomarkers that could potentially be used to monitor the disease and to develop other targeted therapies. We hypothesized that the mediators of cancer metastasis to lung, particularly in breast cancer, also play a relevant role in LAM. Analyses across independent breast cancer datasets revealed associations between low TSC1/2 expression, altered mTOR complex 1 (mTORC1) pathway signaling, and metastasis to lung. Subsequently, immunohistochemical analyses of 23 LAM lesions revealed positivity in all cases for the lung metastasis mediators fascin 1 (FSCN1) and inhibitor of DNA binding 1 (ID1). Moreover, assessment of breast cancer stem or luminal progenitor cell biomarkers showed positivity in most LAM tissue for the aldehyde dehydrogenase 1 (ALDH1), integrin-beta 3 (ITGB3/CD61), and/or the sex-determining region Y-box 9 (SOX9) proteins. The immunohistochemical analyses also provided evidence of heterogeneity between and within LAM cases. The analysis of Tsc2-deficient cells revealed relative over-expression of FSCN1 and ID1; however, Tsc2-deficient cells did not show higher sensitivity to ID1-based cancer inhibitors. Collectively, the results of this study reveal novel LAM biomarkers linked to breast cancer metastasis to lung and to cell stemness, which in turn might guide the assessment of additional or complementary therapeutic opportunities for LAM.