21 resultados para Julio César Avanza

em Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco


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La figura de Julio César, y en particular su asesinato, constituye un tema central en la recepción de la historia de la antigua Roma a lo largo de la modernidad occidental. En este trabajo se pretende hacer un recorrido más o menos rápido por la recepción moderna de ese episodio y comentar su significación política a partir de algunos ejemplos concretos. En realidad, se trata de reflexionar sobre una variante concreta del asesinato político, el tiranicidio, apuntando algunos hitos significativos de la recepción del caso cesariano como puedan ser el drama de William Shakespeare o la película de Joseph Mankiewicz.

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1 carta (manuscrita) ; 225x165 mm

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Este artículo se inscribe dentro del programa de perfeccionamiento postdoctoral en el extranjero del Departamento de Educación, Universidades e Investigación del Gobierno Vasco. Forma parte, asimismo, del proyecto HAR2010-21893: «El discurso sobre el imperio en la República romana: Estrategias de dominación en la oratoria diplomática»

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Background The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a humanized monoclonal antibody that recognizes the EGFR extracellular domain and reaches Central Nervous System tumors, in nonclinical and clinical setting. While it has similar activity when compared to other anti-EGFR antibodies, it does not induce skin toxicity or hypomagnesemia. Methods A randomized, double blind, multicentric clinical trial was conducted in high grade glioma patients (41 anaplastic astrocytoma and 29 glioblastoma multiforme) that received radiotherapy plus nimotuzumab or placebo. Treatment and placebo groups were well-balanced for the most important prognostic variables. Patients received 6 weekly doses of 200 mg nimotuzumab or placebo together with irradiation as induction therapy. Maintenance treatment was given for 1 year with subsequent doses administered every 3 weeks. The objectives of this study were to assess the comparative overall survival, progression free survival, response rate, immunogenicity and safety. Results The median cumulative dose was 3200 mg of nimotuzumab given over a median number of 16 doses. The combination of nimotuzumab and RT was well-tolerated. The most prevalent related adverse reactions included nausea, fever, tremors, anorexia and hepatic test alteration. No anti-idiotypic response was detected, confirming the antibody low immunogenicity. The mean and median survival time for subjects treated with nimotuzumab was 31.06 and 17.76 vs. 21.07 and 12.63 months for the control group. Conclusions In this randomized trial, nimotuzumab showed an excellent safety profile and significant survival benefit in combination with irradiation.

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Santamaría, José Miguel; Pajares, Eterio; Olsen, Vickie; Merino, Raquel; Eguíluz, Federico (eds.)

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Panhelenismo y cosmopolitismo en el pensamiento griego antiguo (Javier Aguirre Santos). - Algunas consideraciones sobre el asesinato de Julio César en la tradición occidental (Antonio Duplá Ansuátegui). - Algunos aspectos de la vida cotidiana en la comedia griega (María José García Soler). - Imperator Caesar Augustus según la «Vida de los Césares» de Suetonio (Isidora Emborujo Salgado). - El género epistolar en la Antigüedad tardía: las Cartas de San Jerónimo (María Teresa Muñoz García de Iturrospe). - La novela erótica griega: Dafnis y Cloe de Longo (Elena Redondo Moyano).

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Editoras Rosa Rabadán; Trinidad Guzmán; Marisa Fernández.

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Editoras Rosa Rabadán; Trinidad Guzmán; Marisa Fernández.

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Editoras Rosa Rabadán; Trinidad Guzmán; Marisa Fernández.

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Fecha: 21-3-1940 (>1970 copia) / Unidad de instalación: Carpeta 45 - Expediente 2-14 / Nº de pág.: 4 (mecanografiadas)

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Fecha: s.f. (>1970 copia) / Unidad de instalación: Carpeta 45 - Expediente 2-17 / Nº de pág.: 2 (mecanografiadas)

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[ES] La documentación contenida en este registro ha servido de base para las siguientes publicaciones:

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Background: Completing a marathon is one of the most challenging sports activities, yet the source of running fatigue during this event is not completely understood. The aim of this investigation was to determine the cause(s) of running fatigue during a marathon in warm weather. Methodology/Principal Findings: We recruited 40 amateur runners (34 men and 6 women) for the study. Before the race, body core temperature, body mass, leg muscle power output during a countermovement jump, and blood samples were obtained. During the marathon (27 uC; 27% relative humidity) running fatigue was measured as the pace reduction from the first 5-km to the end of the race. Within 3 min after the marathon, the same pre-exercise variables were obtained. Results: Marathoners reduced their running pace from 3.5 6 0.4 m/s after 5-km to 2.9 6 0.6 m/s at the end of the race (P,0.05), although the running fatigue experienced by the marathoners was uneven. Marathoners with greater running fatigue (. 15% pace reduction) had elevated post-race myoglobin (1318 6 1411 v 623 6 391 mg L21; P,0.05), lactate dehydrogenase (687 6 151 v 583 6 117 U L21; P,0.05), and creatine kinase (564 6 469 v 363 6 158 U L21; P = 0.07) in comparison with marathoners that preserved their running pace reasonably well throughout the race. However, they did not differ in their body mass change (23.1 6 1.0 v 23.0 6 1.0%; P = 0.60) or post-race body temperature (38.7 6 0.7 v 38.9 6 0.9 uC; P = 0.35). Conclusions/Significance: Running pace decline during a marathon was positively related with muscle breakdown blood markers. To elucidate if muscle damage during a marathon is related to mechanistic or metabolic factors requires further investigation.

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3 cartas (manuscritas) ; entre 210x265mm y 161x222mm. Ubicación: Caja 1 - Carpeta 23