Prioritization of candidate cancer genes-an aid to oncogenomic studies

The development of techniques for oncogenomic analyses such as array comparative genomic hybridization, messenger RNA expression arrays and mutational screens have come to the fore in modern cancer research. Studies utilizing these techniques are able to highlight panels of genes that are altered in cancer. However, these candidate cancer genes must then be scrutinized to reveal whether they contribute to oncogenesis or are coincidental and non-causative. We present a computational method for the prioritization of candidate (i) proto-oncogenes and (ii) tumour suppressor genes from oncogenomic experiments. We constructed computational classifiers using different combinations of sequence and functional data including sequence conservation, protein domains and interactions, and regulatory data. We found that these classifiers are able to distinguish between known cancer genes and other human genes. Furthermore, the classifiers also discriminate candidate cancer genes from a recent mutational screen from other human genes. We provide a web-based facility through which cancer biologists may access our results and we propose computational cancer gene classification as a useful method of prioritizing candidate cancer genes identified in oncogenomic studies.

Foreign Aid Linked to Infrastructure and/or Pollution Abatement

This paper studies the macroeconomic effects of a permanent increase in foreign aid in a model that takes into account environmental quality. We develop a dynamic equilibrium model in which both public investment in infrastructure and environmental protection can be financed using domestic resources and international aid programs. The framework considers four scenarios for international aid: untied aid,aid fully tied to infrastructure, aid fully tied to abatement, and aid equally tied to both types of expenditures. We find that the effects of the transfers may depend on (i) the structural characteristics of the recipient country (the elasticity of substitution in production and its dependence on environment and natural resources) and on (ii) how recipient countries distribute their public expenditure. These results underscore the importance of these factors when deciding how and to what extent to tie aid to infrastructure and/or pollution abatement.

Impacto de la web 2.0 en los perfiles profesionales

En pleno siglo XXI, el uso de Internet y los avances no sólo afectan a las personas sino que las empresas también deben evolucionar al mismo ritmo y adaptar todas sus prácticas a dichos avances. Con la aparición de la Web 2.0, ciertos aspectos de las empresas han quedado obsoletos y se han debido adaptar a la nueva era: la era de la comunicación e de la interacción a través de Internet. Se han creado nuevos modelos de negocio, se han mejorado actividades de la cadena de valor, han surgido nuevas estrategias de marketing y comunicación corporativa y se han creado unos nuevos canales de venta, alrededor del fenómeno e-Commerce. En cuanto a los trabajadores, las empresas han comenzado a valorar nuevas competencias relacionadas con el uso de Internet y la Web 2.0. Dichas competencias pueden ser comunes para muchos puestos de trabajo, por ejemplo el uso de redes sociales o la gestión de la información, otras son más específicas y dependen del puesto de trabajo que consideremos. Finalmente, la aparición de la Web 2.0 ha exigido a las empresas a crear nuevas áreas y puestos de trabajo o modificar los actuales para adecuarse a los nuevos tiempos y tendencias. Así surgen los diferentes perfiles profesionales de las áreas de Estrategia Digital, Marketing Digital, Contenido Digital, Social Media, Análisis Big Data, e-Commerce y Mobile Marketing. Estos perfiles gozan de mucha popularidad y demanda por parte de las empresas y se estima que va a crecer aún más el número de puestos relacionados con el ámbito digital, ya que son las profesiones del futuro.

Financial and Economic Report of a Specific Business Group

As a result of the natural evolution of the economy, ever-changing, unpredictable and cyclical, companies must adapt as far as possible to the changes that have taken place in order to continue with their normal operating activities. Likewise, they should also try to maintain a structure for long-term growth, trying at all times to generate the maximum value. The main objective of this project is to provide financial advisory services to a business group, trying to forward solutions and measures that according to the author can be effective. For this end, the situation of the group in question is analysed from early 2008 to the present day, examining its evolution, what steps have been taken together with their corresponding results and the economic-financial situation of the company at the end of last year. Contact with the company was kept throughout the process of analysis and assessment trying to take advantage of the feedback generated so that the appropriate measures can be adopted if the management considers it to be adequate.