Gehiago Pierre Urteren gramatikaren iturriez: Lilyren gramatika

[EN] Pierre Urte wrote Grammaire cantabrique circa 1714, when he was exiled in England. In this article we want to prove that the main source for Urte’s work was the socalled “Lily’s grammar”, which was the oficial grammar to learn Latin language in England from the 16th to the 19th century. The indentification of that source allows us to support the claim that Urte’s grammar must be included in the tradition of language teaching, as was already pointed out by Oyharçabal (1989). In this article, we first offer a brief history of Lily’s grammar. Then, we provide some clues in order to identify the exact edition used by Urte. Finally, in the main section of the article, we confront the two grammatical works; our aim is to ensure Urte’s debt to Lily’s grammar, and to show in detail the principal parts which Urte took from his source (mainly grammatical clasifications and examples).

Calpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain

Bordetella pertussis, the whooping cough pathogen, secretes several virulence factors among which adenylate cyclase toxin (ACT) is essential for establishment of the disease in the respiratory tract. ACT weakens host defenses by suppressing important bactericidal activities of the phagocytic cells. Up to now, it was believed that cell intoxication by ACT was a consequence of the accumulation of abnormally high levels of cAMP, generated exclusively beneath the host plasma membrane by the toxin N-terminal catalytic adenylate cyclase (AC) domain, upon its direct translocation across the lipid bilayer. Here we show that host calpain, a calcium-dependent Cys-protease, is activated into the phagocytes by a toxin-triggered calcium rise, resulting in the proteolytic cleavage of the toxin N-terminal domain that releases a catalytically active "soluble AC''. The calpain-mediated ACT processing allows trafficking of the "soluble AC'' domain into subcellular organella. At least two strategic advantages arise from this singular toxin cleavage, enhancing the specificity of action, and simultaneously preventing an indiscriminate activation of cAMP effectors throughout the cell. The present study provides novel insights into the toxin mechanism of action, as the calpain-mediated toxin processing would confer ACT the capacity for a space- and time-coordinated production of different cAMP "pools'', which would play different roles in the cell pathophysiology.

El Musteriense de la cueva de Harregi en Aussurucq, Soule (Excavaciones: Pierre Roucher, 1954-1960)

[ES] La cueva de Harregi (Aussurucq, Pays de Soule), excavada por P. Boucher entre 1954 y 1960, contiene testimonios prehistóricos del Paleolítico medio, superior y Postpaleolítico. En este artículo se analizan las evidencias de fauna e industria lítica asimiladas al Paleolítico medio. Importantes alteraciones estratigráficas postdeposicionales modificaron la original posición topográfica de la mayor parte de los depósitos musterienses. La composición global del lote industrial y de la serie faunística recuerdan intensamente a los controlados en los niveles musterienses Cj y Cjr de la muy cercana cueva de Gatzarria. Ello hace, bien plantear la posibilidad de una antigua organización estratigráfica y arqueológica de los depósitos musterienses como la de Gatzarria, lamentablemente perturbada por serios procesos hídricos erosivos, bien contemplar el hecho de una secuencia diferente, propia y, en cierta forma, contradictoria con la dinámica reconocida en Gatzarria.