4 resultados para Conrad, Henry W.
em Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco
Resumo:
[EN] The aim of this paper is to introduce the main contributions of Humboldt to the study of the Basque grammar. His methodological innovations and the influence he had on european linguists are pointed out, the grammatical sources available to him are mentioned and his woks on Basque grammar are enumerated. Some of Humboldt's most interesting analysis are mentioned and are placed in the former and later tradition of the Basque grammar.
Resumo:
During the research that it is summarized in the present memory, the activation of enals via iminium ion catalysis in different transformations has been studied. Firstly, a 1,3-dipolar cycloaddition between stable azomethine ylides and a,b-unsaturated aldehydes catalyzed by a chiral imidazolidinone derivative has been optimized. Employing this methodology we have synthesized a large range of densely substituted pyrroloisoquinolines and pyrrolophthalazines with good yields and high values of diastereo- and enantioselectivity. Moreover, a mechanistic study has been carried out based on DFT calculations and experimental data which have allowed us to propose that the (3+2) cycloaddition reaction follows a sequential Michael addition/Mannich cyclization pathway. The formation of the iminium ion as a result of the condensation between the a,b-unsaturated aldehyde and the catalyst plays an essential role, regarding both reactivity and stereoselectivity. On the other hand we have developed a methodology to carry out a cascade Michael/Henry reaction followed by a sequential dehydration. Starting from simple substrates (2-nitromethylacrilates and a,b-unsaturated aldehydes) and employing a prolinol-derivative catalyst a series of quiral nitrocyclohexadienes have been synthesized.
Resumo:
1 carta (mecanografiada) ; 190x250mm
Resumo:
[es]organización del trabajo en la industria del automovil en el s. XX.
