Biomolecule storage on non-modified thermoplastic microfluidic chip by ink-jet printing of ionogels

[EN] This paper reports an innovative technique for reagents storage in microfluidic devices by means of a one-step UV-photoprintable ionogel-based microarray on non-modified polymeric substrates. Although the ionogel and the ink-jet printing technology are well published, this is the first study where both are used for long-term reagent storage in lab-on-a-chip devices. This technology for reagent storage is perfectly compatible with mass production fabrication processes since pre-treatment of the device substrate is not necessary and inkjet printing allows for an efficient reagent deposition process. The functionality of this microarray is demonstrated by testing the release of biotin-647 after being stored for 1 month at room temperature. Analysis of the fluorescence of the ionogel-based microarray that contains biotin-647 demonstrated that 90% of the biotin-647 present was released from the ionogel-based microarray after pumping PBS 0.1% Tween at 37 °C. Moreover, the activity of biotin-647 after being released from the ionogel-based microarray was investigated trough the binding capability of this biotin to a microcontact printed chip surface with avidin. These findings pave the way for a novel, one-step, cheap and mass production on-chip reagents storage method applicable to other reagents such as antibodies and proteins and enzymes.

Modular integration and on-chip sensing approaches for tunable fluid control polymer microdevices

228 p.

SEM and EDS Characterisation of Layering TiOx Growth onto the Cutting Tool Surface in Hard Drilling Processes of Ti-Al-V Alloys

10 p.

Regulación de la transcripción de los genes SND1 (Homo sapiens) y SNDp102 (Rattus norvegicus)

167 p. : il., graf.

Preprocess and data analysis techniques for affymetrix DNA microarrays using bioconductor: a case study in Alzheimer disease

DNA microarray, or DNA chip, is a technology that allows us to obtain the expression level of many genes in a single experiment. The fact that numerical expression values can be easily obtained gives us the possibility to use multiple statistical techniques of data analysis. In this project microarray data is obtained from Gene Expression Omnibus, the repository of National Center for Biotechnology Information (NCBI). Then, the noise is removed and data is normalized, also we use hypothesis tests to find the most relevant genes that may be involved in a disease and use machine learning methods like KNN, Random Forest or Kmeans. For performing the analysis we use Bioconductor, packages in R for the analysis of biological data, and we conduct a case study in Alzheimer disease. The complete code can be found in https://github.com/alberto-poncelas/ bioc-alzheimer

Desarrollo de circuitos electrónicos para la extracción y conversión en energía eléctrica de la vibración aplicada a materiales piezoeléctricos

xx,145 p.

Compensación del factor de potencia en instalaciones eléctricas industriales de baja tensión.

[ES]En las últimas décadas, la optimización de las instalaciones eléctricas se ha convertido en una de las prioridades más importantes de las empresas. En este sentido, la corrección del factor de potencia supone un importante tema a analizar y resolver. Hoy en día, se dispone de muchos métodos de compensación, pero en la mayoría de los casos, la implementación de baterías de condensadores resulta la mejor opción. Por otra parte, dependiendo de la distribución elegida en la instalación de los condensadores, se consiguen ciertas ventajas y desventajas en cuanto a componentes reactivas en el sistema eléctrico y costes finales de la compensación se refiere. Además del desarrollo teórico, se dispondrá de simulaciones realizadas en herramientas de cálculo que ayudarán a la comprobación de estas ideas.

Gain Scheduling Control of an Islanded Microgrid Voltage

The aim of this research study has been to design a gain scheduling (GS) digital controller in order to control the voltage of an islanded microgrid in the presence of fast varying loads (FVLs), and to compare it to a robust controller. The inverter which feeds the microgrid is connected to it through an inductance-capacitor-inductance (LCL) filter. The oscillatory and nonlinear behaviour of the plant is analyzed in the whole operating zone. Afterwards, the design of the controllers which contain two loops in cascade are described. The first loop concerns the current control, while the second is linked to the voltage regulation. Two controllers, one defined as Robust and another one as GS controller, are designed for the two loops, emphasizing in their robustness and their ability to damp the oscillatory plant behaviour. To finish, some simulations are carried out to study and compare the two kinds of controllers in different operating points. The results show that both controllers damp the oscillatory behaviour of the plant in closed loop (CL), and that the GS controller ensures a better rejection of current disturbances from FVLs.

Diseño de un sistema para la detección y caracterización de impactos sobre estructuras.

[ES]Este documento pretende describir de manera clara y concisa la creacion de un dispositivo detector de impactos para estructuras de avion durante su transporte de muy bajo consumo, desde su concepcion como idea hasta su montaje, programacion y posterior comprobacion. El objetivo sera la culminacion exitosa del producto para mas adelante exponerlo ante posibles compradores y/o investigadores. Este dispositivo esta compuesto de tres partes, una unidad de adquisicion y adecuacion de la señal, que ser a recogida por un piezoelectrico; la unidad de inteligencia, que sera un microcontrolador programado en ensamblador mediante la herramienta MPLAB y un chip de radio, que se encargara de transmitir los datos a una unidad mas potente, lease un PC, tablet, movil...

Scalable quantum memory in the ultrastrong coupling regime

Circuit quantum electrodynamics, consisting of superconducting artificial atoms coupled to on-chip resonators, represents a prime candidate to implement the scalable quantum computing architecture because of the presence of good tunability and controllability. Furthermore, recent advances have pushed the technology towards the ultrastrong coupling regime of light-matter interaction, where the qubit-resonator coupling strength reaches a considerable fraction of the resonator frequency. Here, we propose a qubit-resonator system operating in that regime, as a quantum memory device and study the storage and retrieval of quantum information in and from the Z(2) parity-protected quantum memory, within experimentally feasible schemes. We are also convinced that our proposal might pave a way to realize a scalable quantum random-access memory due to its fast storage and readout performances.