Las medidas de acogimiento y su influencia en los menores desprotegidos

[ES]En el presente trabajo se realiza un recorrido teórico de la familia, de los deberes y obligaciones que les corresponden a los padres para con sus hijos, además de estudiarse cómo el cese o la mala práctica de esos compromisos pueden incidir negativamente en ellos. Exponiéndose los diferentes tipos de maltrato infantil, se explican las medidas de acogimiento que se adoptan cuando la situación familiar es considerada perjudicial o peligrosa para el menor. Para ello, mediante entrevistas a distintos profesionales y técnicos de la Sección de Protección a la Infancia de la provincia de Bizkaia, se da a conocer la situación actual de los centros y hogares de acogimiento, la visión profesional acerca de la problemática presentada, los planes creados para el acogimiento familiar, y cómo es el proceso de captación de familias de acogida. Así mismo, se recoge el testimonio de una persona acogida en la infancia.

The promoter of cell growth- and RNA protection-associated SND1 gene is activated by endoplasmic reticulum stress in human hepatoma cells

Background: Staphyloccocal nuclease domain-containing protein 1 (SND1) is involved in the regulation of gene expression and RNA protection. While numerous studies have established that SND1 protein expression is modulated by cellular stresses associated with tumor growth, hypoxia, inflammation, heat- shock and oxidative conditions, little is known about the factors responsible for SND1 expression. Here, we have approached this question by analyzing the transcriptional response of human SND1 gene to pharmacological endoplasmic reticulum (ER) stress in liver cancer cells. Results: We provide first evidence that SND1 promoter activity is increased in human liver cancer cells upon exposure to thapsigargin or tunicamycin or by ectopic expression of ATF6, a crucial transcription factor in the unfolded protein response triggered by ER stress. Deletion analysis of the 5'-flanking region of SND1 promoter identified maximal activation in fragment (-934, +221), which contains most of the predicted ER stress response elements in proximal promoter. Quantitative real- time PCR revealed a near 3 fold increase in SND1 mRNA expression by either of the stress- inducers; whereas SND1 protein was maximally upregulated (3.4-fold) in cells exposed to tunicamycin, a protein glycosylation inhibitor. Conclusion: Promoter activity of the cell growth- and RNA-protection associated SND1 gene is up-regulated by ER stress in human hepatoma cells.

Evaluation of a programme to improve emotional intelligence during adolescence

348 p.