Cartas enviadas por José Antonio Aguirre a Justo Garate entre 1933-1946

7 cartas (mecanografiadas) ; entre 215x286mm y 157x215mm. Ubicación: Caja 1 - Carpeta 10

Cartas enviadas por Karl Bouda a Justo Garate entre 1934 y 1946

9 cartas + 2 tarjetas postales (manuscritas) ; entre 330x225mm y 100x60mm

Reproducción de Tarjeta de visita de Eliodoro de la Torre.

Fecha: s.f. (>1970 reproducción) / Unidad de instalación: Carpeta 25 - Expediente 23-5 / Nº de pág.: 1 (mecanografiada)

Copia de una carta remitida por el obispo Mateo Múgica al Presidente del Gobierno Vasco en el exilio.

Fecha: 19-3-1946 (>1970 copia) / Unidad de instalación: Carpeta 45 - Expediente 2-24 / Nº de pág.: 3 (mecanografiadas)

Dobutamine in Paediatric Population: A Systematic Review in Juvenile Animal Models

Objective: Although dobutamine is widely used in neonatal clinical practice, the evidence for its use in this specific population is not clear. We conducted a systematic review of the use of dobutamine in juvenile animals to determine whether the evidence from juvenile animal experiments with dobutamine supported the design of clinical trials in neonatal/ paediatric population. Methods: Studies were identified by searching MEDLINE (1946-2012) and EMBASE (1974-2012). Articles retrieved were independently reviewed by three authors and only those concerning efficacy and safety of the drug in juvenile animals were included. Only original articles published in English and Spanish were included. Results: Following our literature search, 265 articles were retrieved and 24 studies were included in the review: 17 focused on neonatal models and 7 on young animal models. Although the aims and design of these studies, as well as the doses and ages analysed, were quite heterogeneous, the majority of authors agree that dobutamine infusion improves cardiac output in a dose dependent manner. Moreover, the cardiovascular effects of dobutamine are influenced by postnatal age, as well as by the dose used and the duration of the therapy. There is inadequate information about the effects of dobutamine on cerebral perfusion to draw conclusions. Conclusion: There is enough preclinical evidence to ensure that dobutamine improves cardiac output, however to better understand its effects in peripheral organs, such as the brain, more specific and well designed studies are required to provide additional data to support the design of clinical trials in a paediatric population.