San Pedro berraktibatzen

Pasai San Pedroko Herrikoplaza-ko inguruaren birplanteaketa erabilera berrien integrazioaren eta irisgarritasunaren hobekuntzaren bidez.

Escultura romanista en Gipuzkoa. El taller de Tolosa

El romanismo, estilo al que pertenecen las obras escultóricas estudiadas en este libro, es una adaptación del manierismo italiano de Miguel Ángel y sus seguidores que se caracteriza por la concepción de figuras de gran idealización, de anatomía exaltada y pletóricas de fuerza. En esta publicación se analizan con detenimiento los retablos de finales del siglo XVI y comienzos del XVII en sus vertientes arquitectónica, escultural y pictórica de esta zona geográfica comprendida en el norte de la Península. Se trata de un tema poco estudiado y con su abordaje se han intentado proporcionar las herramientas para que estas obras, algunas de ellas recientemente restauradas, sean valoradas y apreciadas como se merecen. Para ello, las obras se encuadran en el marco político, administrativo, religioso y artístico del entorno de Tolosa, en Gipuzkoa, donde en el cambio de centuria artistas como Jerónimo de Larrea o Pedro de Goicoechea realizaron los retablos mayores de Itsasondo o Irura, en los que se consolida este nuevo estilo contrarreformista. El romanismo se ve analizado en su vertiente estilística, iconográfica o en sus fuentes gráficas, mientras que en cuanto a los artistas estudiados se centra la atención en los aspectos biográficos y profesionales, ofreciendo un amplio catálogo de obras que se distribuyen en el curso del río Oria, desde el actual Goierri hasta la costa cantábrica.

Transformaciones en el retablo mayor de San Miguel Arcángel de Lazkao (Gipuzkoa): del Barroco al Neoclasicismo

[ES] El retablo mayor de la localidad guipuzcoana de Lazkao fue realizado por Juan de Ursularre en 1683, siguiendo los parámetros de la retablística barroca. Queriendo engrandecer su aspecto, fue paulatinamente transformado durante el siglo XVIII. Por ello se concibió un nuevo cascarón con pinturas enviadas desde Madrid y más tarde se adecuó a los nuevos gustos neoclásicos mediante una radical reforma realizada en 1791 que consistió en eliminar todo atisbo de decoración barroca.

Undertreatment of human immunodeficiency virus in psychiatric inpatients: a cross-sectional study of seroprevalence and associated factors

Background: The aims of this study were to evaluate the prevalence of HIV and its associated demographic and clinical factors among psychiatric inpatients of a general hospital. Methods: This was a single-center, observational, cross-sectional study that included patients consecutively admitted to our unit aged 16 years or older and with no relevant cognitive problems. The patients were evaluated using a semistructured interview and an appropriate test for HIV infection. Results: Of the 637 patients who were screened, 546 (86%) who consented to participate were included in the analyses. Twenty-five (4.6%, 95% confidence interval [CI] 3.0-6.8) patients were HIV-positive. The prevalence was higher among patients with substance misuse (17.4%, 95% CI 9.7-28.8). All except one of the 25 patients knew of their seropositive condition prior to participation in the study. Only 14 (56%) of the 25 seropositive patients had previously received pharmacological treatment for their infection. According to the multiple logistic regression analysis, the likelihood of HIV infection was lower in patients with higher levels of education and higher among patients who were single, had history of intravenous drug use, and had an HIV-positive partner, particularly if they did not use condoms. Among the patients with HIV infection, 18 (72%) had a history of suicide attempts compared with 181 (34.7%) of the patients without HIV infection (relative risk 2.1, 95% CI 1.6-2.7; P<0.001). Conclusion: HIV infection is highly prevalent in patients admitted to a psychiatric unit, especially those with a diagnosis of substance misuse. Seropositive patients show very poor treatment adherence. The risk of suicide seems to be very high in this population. Implementing interventions to reduce the suicide risk and improve adherence to antiretroviral therapy and psychotropic medications seems crucial.

2015 urteko Trintxerpe-San Pedro San Silvestre lasterketarako proiektua

2015. urteko Trintxerpe-San Pedro San Silvestre lasterketaren proiektua izango da lan hau. Lasterketa osoa antolatuko da.

Pan para hoy...¿Hambre para mañana?

Nivel educativo: Grado. Duración (en horas): De 31 a 40 horas

Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle

Cannabinoid CB1 receptors peripherally modulate energy metabolism. Here, we investigated the role of CB1 receptors in the expression of glucose/pyruvate/tricarboxylic acid (TCA) metabolism in rat abdominal muscle. Dihydrolipoamide dehydrogenase (DLD), a flavoprotein component (E3) of alpha-ketoacid dehydrogenase complexes with diaphorase activity in mitochondria, was specifically analyzed. After assessing the effectiveness of the CB1 receptor antagonist AM251 (3 mg kg(-1), 14 days) on food intake and body weight, we could identified seven key enzymes from either glycolytic pathway or TCA cycle-regulated by both diet and CB1 receptor activity-through comprehensive proteomic approaches involving two-dimensional electrophoresis and MALDI-TOF/LC-ESI trap mass spectrometry. These enzymes were glucose 6-phosphate isomerase (GPI), triosephosphate isomerase (TPI), enolase (Eno3), lactate dehydrogenase (LDHa), glyoxalase-1 (Glo1) and the mitochondrial DLD, whose expressions were modified by AM251 in hypercaloric diet-induced obesity. Specifically, AM251 blocked high-carbohydrate diet (HCD)-induced expression of GPI, TPI, Eno3 and LDHa, suggesting a down-regulation of glucose/pyruvate/lactate pathways under glucose availability. AM251 reversed the HCD-inhibited expression of Glo1 and DLD in the muscle, and the DLD and CB1 receptor expression in the mitochondrial fraction. Interestingly, we identified the presence of CB1 receptors at the membrane of striate muscle mitochondria. DLD over-expression was confirmed in muscle of CB1-/- mice. AM251 increased the pyruvate dehydrogenase and glutathione reductase activity in C2C12 myotubes, and the diaphorase/oxidative activity in the mitochondria fraction. These results indicated an up-regulation of methylglyoxal and TCA cycle activity. Findings suggest that CB1 receptors in muscle modulate glucose/pyruvate/lactate pathways and mitochondrial oxidative activity by targeting DLD.