376 resultados para Cercas, Javier
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[Es] Este estudio analiza la opinión de los alumnos de diferentes licenciaturas sobre la utilidad didáctica de las tecnologías de la información y comunicación (TICs) en la universidad. Se utilizaron páginas web y el correo electrónico para facilitar diferentes herramientas educativas (guiones docentes, artículos, páginas web, trabajos prácticos y bibliografía). Los análisis univariante y multivariante de los datos obtenidos de las encuestas realizadas a los estudiantes al inicio y final de la asignatura, demuestran que, con independencia de la titulación, el 64% del alumnado considera que la utilización de las TICs mejora la comunicación alumno – profesor, e incrementa la motivación y la participación activa del estudiante.
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Background: Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive genetic disease characterized by the lack of reaction to noxious stimuli and anhidrosis. It is caused by mutations in the NTRK1 gene, which encodes the high affinity tyrosine kinase receptor I for Neurotrophic Growth Factor (NGF). -- Case Presentation: We present the case of a female patient diagnosed with CIPA at the age of 8 months. The patient is currently 6 years old and her psychomotor development conforms to her age (RMN, SPECT and psychological study are in the range of normality). PCR amplification of DNA, followed by direct sequencing, was used to investigate the presence of NTRK1 gene mutations. Reverse transcriptase (RT)-PCR amplification of RNA, followed by cloning and sequencing of isolated RT-PCR products was used to characterize the effect of the mutations on NTRK1 mRNA splicing. The clinical diagnosis of CIPA was confirmed by the detection of two splice-site mutations in NTRK1, revealing that the patient was a compound heterozygote at this gene. One of these alterations, c.574+1G > A, is located at the splice donor site of intron 5. We also found a second mutation, c.2206-2 A > G, not previously reported in the literature, which is located at the splice acceptor site of intron 16. Each parent was confirmed to be a carrier for one of the mutations by DNA sequencing analysis. It has been proposed that the c.574+1G > A mutation would cause exon 5 skipping during NTRK1 mRNA splicing. We could confirm this prediction and, more importantly, we provide evidence that the novel c.2206-2A > G mutation also disrupts normal NTRK1 splicing, leading to the use of an alternative splice acceptor site within exon 17. As a consequence, this mutation would result in the production of a mutant NTRK1 protein with a seven aminoacid in-frame deletion in its tyrosine kinase domain. --Conclusions: We present the first description of a CIPA-associated NTRK1 mutation causing a short interstitial deletion in the tyrosine kinase domain of the receptor. The possible phenotypical implications of this mutation are discussed.
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MELECON 2012 - 2012 16th IEEE Mediterranean Electrotechnical Conference, 25 Mar - 28 Mar 2012, Túnez
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MELECON 2012 - 2012 16th IEEE Mediterranean Electrotechnical Conference, 25 Mar - 28 Mar 2012, Túnez
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Background: Few studies have analyzed predictors of length of stay (LOS) in patients admitted due to acute bipolar manic episodes. The purpose of the present study was to estimate LOS and to determine the potential sociodemographic and clinical risk factors associated with a longer hospitalization. Such information could be useful to identify those patients at high risk for long LOS and to allocate them to special treatments, with the aim of optimizing their hospital management. Methods: This was a cross-sectional study recruiting adult patients with a diagnosis of bipolar disorder (Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM-IV-TR) criteria) who had been hospitalized due to an acute manic episode with a Young Mania Rating Scale total score greater than 20. Bivariate correlational and multiple linear regression analyses were performed to identify independent predictors of LOS. Results: A total of 235 patients from 44 centers were included in the study. The only factors that were significantly associated to LOS in the regression model were the number of previous episodes and the Montgomery-Åsberg Depression Rating Scale (MADRS) total score at admission (P < 0.05). Conclusions: Patients with a high number of previous episodes and those with depressive symptoms during mania are more likely to stay longer in hospital. Patients with severe depressive symptoms may have a more severe or treatment-resistant course of the acute bipolar manic episode.
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[ES] En este trabajo realizamos un análisis de los artículos sobre contabilidad medioambiental publicados en las principales revistas españolas de gestión, durante el periodo 1993-2003. De esta forma, analizamos la situación actual y la evolución de la investigación en esta línea durante el periodo señalado, así como el papel desempeñado por las distintas revistas en el desarrollo del conocimiento sobre esta materia.
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La idea de globalización, asumida hoy en día desde numerosos ámbitos de la sociedad moderna, tiene sus propios referentes teóricos en la Grecia Antigua. A lo largo de la historia de la literatura y pensamiento griegos puede apreciarse un progresivo desplazamiento desde la idea de comunidad cerrada, dominante en la época arcaica, a la doctrina panhelenista de la época clásica y la doctrina de la polis universal, desarrollada en la época helenística e imperial.
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[ES] El presente trabajo analiza la relación entre el control familiar y la credibilidad de los resultados contables. Utilizando un panel de datos de empresas españolas cotizadas no financieras para el período 1997-2003, los resultados alcanzados muestran que la credibilidad de la información contable de la empresa familiar es inferior a la de la no familiar. Asimismo, el incremento de los derechos de voto en manos del último propietario familiar incide negativamente en la credibilidad de sus resultados divulgados. Las únicas empresas en las que la naturaleza familiar incide positivamente en la credibilidad de la información contable son aquellas en las que el presidente del consejo de administración no pertenece a la familia controladora.
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617 p.: il.col., graf.
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417 p. : graf.
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[ES] El proceso de Bolonia ha remarcado una perspectiva institucional en la preocupación por la gestión de la calidad del servicio prestado en las universidades y otras instituciones de enseñanza superior. La calidad del servicio en la educación superior no se centra exclusivamente en el proceso de enseñanza- aprendizaje y en la relación entre docente y discente, sino que debe estar también garantizada en el servicio prestado por las bibliotecas universitarias, los servicios de acción social, los servicios académicos y las secretarías departamentales.
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Ejemplar dedicado a: Serta Palaeohispanica in honorem Javier de Hoz
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In this paper, the influence on corrugation of the most significant track parameters has been examined. After this parametric study, the optimization of the track parameters to minimize the undulatory wear growth has been achieved. Finally, the influence of the dispersion of the track and contact parameters on corrugation growth has been studied. A method has been developed to obtain an optimal solution of the track parameters which minimizes corrugation growth, thus ensuring that this solution remains optimum despite dispersion of track parameters and wheel-rail contact uncertainties. This work is based on the computer application RACING (RAil Corrugation INitiation and Growth) which has been developed by the authors to predict rail corrugation features.
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Traducido al castellano e inglés
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This work shows the method developed to solve the wheel-rail contact problem via a look-up table with a three-dimensional elastic model. This method enables introduction of the two contact point effect on vehicle movement using three-dimensional analysis of surfaces including the influence of the angle of attack. This work presents several dynamic simulations and studies the impact that the introduction of the two contact points on three dimensions has on wear indexes and derailment risk against traditional bidimensional analysis. Furthermore, it studies advantages and disadvantages of using a look-up table against an on-line resolution of the problem.