Datos preliminares sobre fuentes de aprovisionamiento de rocas silíceas en algunos yacimientos paleolíticos y postpaleolíticos del sector oriental de la cuenca vasco-cantábrica

[ES] Exponemos en este trabajo los primeros resultados referentes a las áreas de aprovisionamiento de materiales silíceos en el sector oriental de la Cuenca Vasco-Cantábrica durante el Pleistoceno superior y Holoceno. Se describen aquellos afloramientos cuyos sílex han sido identificados en varios yacimientos del periodo contemplado. Hemos constatado una transformación sustancial de las estrategias de aprovisionamiento, observable a fines del Paleolítico y especialmente significativa desde el Epipaleolítico. Asimismo, las pautas de ocupación del territorio reflejadas muestran indicios de un aprovechamiento rentable, estacional, de tierras en torno a los 600 m.s.n.m. durante el Pleistoceno superior, y con territorios de explotación probablemente de mayor extensión que los contemplados hasta el momento por la historiografía del Paleolítico cantábrico.

Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results

Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared by coupling the molecular features of two well-known drugs, ie, rimonabant and fentanyl. The new compounds have been tested for their affinity and functionality regarding CB1 and CB2 cannabinoid and mu opioid receptors. In [S-35]-GTP.S (guanosine 5'-O-[gamma-thio] triphosphate) binding assays from the post-mortem human frontal cortex, they proved to be CB1 cannabinoid antagonists and mu opioid antagonists. Interestingly, in vivo, the new compounds exhibited a significant dual antagonist action on the endocannabinoid and opioid systems.

Quantum Simulator for Transport Phenomena in Fluid Flows

Transport phenomena still stand as one of the most challenging problems in computational physics. By exploiting the analogies between Dirac and lattice Boltzmann equations, we develop a quantum simulator based on pseudospin-boson quantum systems, which is suitable for encoding fluid dynamics transport phenomena within a lattice kinetic formalism. It is shown that both the streaming and collision processes of lattice Boltzmann dynamics can be implemented with controlled quantum operations, using a heralded quantum protocol to encode non-unitary scattering processes. The proposed simulator is amenable to realization in controlled quantum platforms, such as ion-trap quantum computers or circuit quantum electrodynamics processors.

Parte de guerra del Batallón Euzko Indarra de ANV, firmado por el Comisario Político Bernabé Orbegozo y el Comisario General Luis Ruiz de Aguirre

Fecha: 18 de julio de 1937 / Unidad de ínstalación: Carpeta Rectorado - E-1 / Nº de pág.: 1 (Mecanografiada y firmas manuscritas)

Notificación de las posiciones ocupadas por el Batallón Euzko Indarra de ANV, firmada por ordén del Comisario político al Comisario General Luis Ruiz de Aguirre

Fecha: 19-7-1937 / Unidad de ínstalación: Carpeta Rectorado - E-2 / Nº de pág.: 1 (Mecanografiada y firma manuscrita del Delegado ayudante)

Nombramiento de Luis Ruiz de Aguirre como Comisario Político de ANV, firmado por el jefe de operaciones del Ejército de Euzkadi

Fecha: 19-4-1937 / Unidad de ínstalación: Carpeta Rectorado - F-1 / Nº de pág.: 1 (mecanografiado y firma manuscrita)

Notificación de Leopoldo Gaspar a Luis Ruiz de Aguirre sobre el nombramiento de un comisario en el Regimiento de carros de combate

Fecha: 14-8-1937 / Unidad de ínstalación: Carpeta Rectorado - F-2 / Nº de pág.: 1 (mecanografiada y firma manuscrita)

Certificado del Delegado del Gobierno de Euzkadi en Bayona, Javier de Gortazar, expedido a Luis Ruiz de Aguirre, en el que se hace constar que forma parte del personal del Departamento de Agricultura del Gobierno de Euzkadi

Fecha: 1-9-1937 / Unidad de ínstalación: Carpeta Rectorado - F-3 / Nº de hojas: 1. Mecanografiado y firma manuscrita

Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness

Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 (TSC1 or TSC2) genes. While allosteric inhibition of the mechanistic target of rapamycin (mTOR) has shown substantial clinical benefit, complementary therapies are required to improve response and/or to treat specific patients. However, there is a lack of LAM biomarkers that could potentially be used to monitor the disease and to develop other targeted therapies. We hypothesized that the mediators of cancer metastasis to lung, particularly in breast cancer, also play a relevant role in LAM. Analyses across independent breast cancer datasets revealed associations between low TSC1/2 expression, altered mTOR complex 1 (mTORC1) pathway signaling, and metastasis to lung. Subsequently, immunohistochemical analyses of 23 LAM lesions revealed positivity in all cases for the lung metastasis mediators fascin 1 (FSCN1) and inhibitor of DNA binding 1 (ID1). Moreover, assessment of breast cancer stem or luminal progenitor cell biomarkers showed positivity in most LAM tissue for the aldehyde dehydrogenase 1 (ALDH1), integrin-beta 3 (ITGB3/CD61), and/or the sex-determining region Y-box 9 (SOX9) proteins. The immunohistochemical analyses also provided evidence of heterogeneity between and within LAM cases. The analysis of Tsc2-deficient cells revealed relative over-expression of FSCN1 and ID1; however, Tsc2-deficient cells did not show higher sensitivity to ID1-based cancer inhibitors. Collectively, the results of this study reveal novel LAM biomarkers linked to breast cancer metastasis to lung and to cell stemness, which in turn might guide the assessment of additional or complementary therapeutic opportunities for LAM.

Luminescence and Magnetic Properties of Two Three -Dimensional Terbium and Dysprosium MOFs Based on Azobenzene-4,4 '-Dicarboxylic Linker

We report the in situ formation of two novel metal-organic frameworks based on terbium and dysprosium ions using azobenzene-4,4-dicarboxylic acid (H(2)abd) as ligand, synthesized by soft hydrothermal routes. Both materials show isostructural three-dimensional networks with channels along a axis and display intense photoluminescence properties in the solid state at room temperature. Textural properties of the metal-organic frameworks (MOFs) have been fully characterized although no appreciable porosity was obtained. Magnetic properties of these materials were studied, highlighting the dysprosium material displays slightly frequency-dependent out of phase signals when measured under zero external field and under an applied field of 1000 Oe.