Cartas enviadas por José María Bengoa a Justo Garate entre 1947 y 1961

11 cartas (mecanografiadas y manuscritas); entre 170x225mm y 215x275mm

Cartas enviadas por José María Bengoa a Justo Garate entre 1962 y 1992

8 cartas (mecanografiadas y manuscritas); entre 150x210mm y 215x275mm .- 1 Felicitación de Navidad (manuscrita y sin fecha) ; 110mmx160mm

Carta enviada por José Berruezo a Justo Garate en 1973

1 carta (mecanografiada) ; 215x300mm

El arbitraje en el derecho internacional privado

La universalidad como un conglomerado natural de grupos sociales, dio paso después de una revolución industrial denominada globalización, que para su estudio tenemos que descomponer. El presente trabajo se inscribe en este sentido puesto que pretende introducirnos en el tema a través de la identificación del instrumento que ha sido vector y soporte de su consagración.

Epitope mapping of antibodies to alpha-synuclein in LRRK2 mutation carriers, idiopathic Parkinson disease patients, and healthy controls

Alpha-synuclein (Snca) plays a major role in Parkinson disease (PD). Circulating anti-Snca antibodies has been described in PD patients and healthy controls, but they have been poorly characterized. This study was designed to assess the prevalence of anti-Snca reactivity in human subjects carrying the LRRK2 mutation, idiopathic PD (iPD) patients, and healthy controls and to map the epitopes of the anti-Snca antibodies. Antibodies to Snca were detected by ELISA and immunoblotting using purified recombinant Snca in plasma from individuals carrying LRRK2 mutations (104), iPD patients (59), and healthy controls (83). Epitopes of antibodies were mapped using recombinant protein constructs comprising different regions of Snca. Clear positive anti-Snca reactivity showed no correlation with age, sex, years of evolution, or the disability scores for PD patients and anti-Snca reactivity was not prevalent in human patients with other neurological or autoimmune diseases. Thirteen of the positive individuals were carriers of LRRK2 mutations either non-manifesting (8 out 49 screened) or manifesting (5 positive out 55), three positive (out of 59) were iPD patients, and five positive (out of 83) were healthy controls. Epitope mapping showed that antibodies against the N-terminal (a.a. 1-60) or C-terminal (a.a. 109-140) regions of Snca predominate in LRRK2 mutation carriers and iPD patients, being N122 a critical amino acid for recognition by the anti-C-terminal directed antibodies. Anti-Snca circulating antibodies seem to cluster within families carrying the LRRK2 mutation indicating possible genetic or common environmental factors in the generation of anti-Snca antibodies. These results suggest that case-controls' studies are insufficient and further studies in family cohorts of patients and healthy controls should be undertaken, to progress in the understanding of the possible relationship of anti-Snca antibodies and PD patholog

Proposal and validation of methodologies for the categorisation of continuous variables in the development of prediction models

158 p.

La gestación por sustitución: análisis desde la óptica del Derecho Internacional Privado

El presente Trabajo Fin de Grado pretende, principalmente, arrojar cierta luz sobre todos los interrogantes que surgen en torno a la gestación por sustitución. De manera que, el objetivo fundamental del Trabajo se articula a partir de un análisis pormenorizado de las diferentes corrientes legistlativas y jurisprudenciales en torno a la materia, poniendo especial énfasis en la conjunción del respeto del orden público y las libertades individuales. Esto es, la armonía entre la legislación vigente y los derechos e intereses de los individuos que intervengan en el desarollo de la gestación por sustitución.

Caso Prestige: hacia un compromiso con el medio ambiente

El presente trabajo tiene como objetivofundamental situar el naufragio del petrolero Prestige en su contexto jurídico internacional tanto en lo relativo al análisis de la responsabilidad limitada, como en la reparación del daño ocasionado. Básicamente, en el presente trabajo se analizará con detenimiento la normativa vigente en el momento del naufragio del buque y acorde con ese entramado de normas, que alcance puede tener la reparación. Finalmente, se concluirá mencionando esos aspectos que considero que deber ser mejorados con el único fin de preservar el medio ambiente.

Effect of Neonatal Asphyxia on the Impairment of the Auditory Pathway by Recording Auditory Brainstem Responses in Newborn Piglets: A New Experimentation Model to Study the Perinatal Hypoxic-Ischemic Damage on the Auditory Syste

Introduction Hypoxia-ischemia (HI) is a major perinatal problem that results in severe damage to the brain impairing the normal development of the auditory system. The purpose of the present study is to study the effect of perinatal asphyxia on the auditory pathway by recording auditory brain responses in a novel animal experimentation model in newborn piglets. Method Hypoxia-ischemia was induced to 1.3 day-old piglets by clamping 30 minutes both carotid arteries by vascular occluders and lowering the fraction of inspired oxygen. We compared the Auditory Brain Responses (ABRs) of newborn piglets exposed to acute hypoxia/ischemia (n = 6) and a control group with no such exposure (n = 10). ABRs were recorded for both ears before the start of the experiment (baseline), after 30 minutes of HI injury, and every 30 minutes during 6 h after the HI injury. Results Auditory brain responses were altered during the hypoxic-ischemic insult but recovered 30-60 minutes later. Hypoxia/ischemia seemed to induce auditory functional damage by increasing I-V latencies and decreasing wave I, III and V amplitudes, although differences were not significant. Conclusion The described experimental model of hypoxia-ischemia in newborn piglets may be useful for studying the effect of perinatal asphyxia on the impairment of the auditory pathway.