Elektrioestimulazioak eskaladako test espezifikoetan duen eragina ikusteko Oñatiko eskalatzaileekin eginiko interbentzioa

Elektroestimulazioak eskaladako test espezifikoetan duen eragina ikusteko, maila ezberdineko Oñatiko bederatzi eskalatzaileri egindako interbentzioa da.

Análisis de la mejora en el rendimiento en el test de 20 minutos en diez remeros de élite

En el siguiente estudio se analiza, mediante el test de 20 minutos, la mejora en el rendimiento de diez remeros pertenecientes a un club de elite. Estos sujetos, se sometieron a dos test en diferentes fechas de la temporada. Se hizo una comparación entre ambas pruebas. Las variables analizadas en esa comparación y que muestran la evolución de los deportistas son las siguientes: wattios, ritmo y frecuencia cardiaca. Analizando los wattios se calculó la potencia obtenida durante todo el test, con el ritmo nos referimos a las paladas por minuto y mirando la frecuencia cardiaca pudimos obtener dos indicadores: cuál es el porcentaje de la frecuencia cardiaca máxima con la que cada deportista realizó la prueba y en qué medida recuperaba cada sujeto.

Análisis de la percepción de la fatiga en test de fuerza-resistencia; comparación entre elementos elásticos y carga fija.

Al inicio del plan de tutorización que se ha llevado a cabo durante el presente curso 2014-2015, la idea que plantee, se relacionaba con aspectos del ámbito del entrenamiento de la actividad física, y más concretamente con el entrenamiento personal o personal coaching. Esta primera propuesta, debatida en las primeras reuniones con el tutor, fue descartada, y a posteriori, inicie un proceso de reflexión conjuntamente y bajo las directrices del tutor del trabajo, en el ámbito de la especificidad del trabajo de fuerza. Este trabajo de reflexión concluyó en la primera etapa del proceso de tutorización con la propuesta de un título provisional en relación al análisis comparado en los ejercicios de tracción con elementos elásticos y con carga fija, título inicial, que ha prefijado la estrategia del trabajo de fin de grado

Dobutamine in Paediatric Population: A Systematic Review in Juvenile Animal Models

Objective: Although dobutamine is widely used in neonatal clinical practice, the evidence for its use in this specific population is not clear. We conducted a systematic review of the use of dobutamine in juvenile animals to determine whether the evidence from juvenile animal experiments with dobutamine supported the design of clinical trials in neonatal/ paediatric population. Methods: Studies were identified by searching MEDLINE (1946-2012) and EMBASE (1974-2012). Articles retrieved were independently reviewed by three authors and only those concerning efficacy and safety of the drug in juvenile animals were included. Only original articles published in English and Spanish were included. Results: Following our literature search, 265 articles were retrieved and 24 studies were included in the review: 17 focused on neonatal models and 7 on young animal models. Although the aims and design of these studies, as well as the doses and ages analysed, were quite heterogeneous, the majority of authors agree that dobutamine infusion improves cardiac output in a dose dependent manner. Moreover, the cardiovascular effects of dobutamine are influenced by postnatal age, as well as by the dose used and the duration of the therapy. There is inadequate information about the effects of dobutamine on cerebral perfusion to draw conclusions. Conclusion: There is enough preclinical evidence to ensure that dobutamine improves cardiac output, however to better understand its effects in peripheral organs, such as the brain, more specific and well designed studies are required to provide additional data to support the design of clinical trials in a paediatric population.

Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS

Background: There is growing evidence that microglia are key players in the pathological process of amyotrophic lateral sclerosis (ALS). It is suggested that microglia have a dual role in motoneurone degeneration through the release of both neuroprotective and neurotoxic factors. Results: To identify candidate genes that may be involved in ALS pathology we have analysed at early symptomatic age (P90), the molecular signature of microglia from the lumbar region of the spinal cord of hSOD1(G93A) mice, the most widely used animal model of ALS. We first identified unique hSOD1(G93A) microglia transcriptomic profile that, in addition to more classical processes such as chemotaxis and immune response, pointed toward the potential involvement of the tumour suppressor gene breast cancer susceptibility gene 1 (Brca1). Secondly, comparison with our previous data on hSOD1(G93A) motoneurone gene profile substantiated the putative contribution of Brca1 in ALS. Finally, we established that Brca1 protein is specifically expressed in human spinal microglia and is up-regulated in ALS patients. Conclusions: Overall, our data provide new insights into the pathogenic concept of a non-cell-autonomous disease and the involvement of microglia in ALS. Importantly, the identification of Brca1 as a novel microglial marker and as possible contributor in both human and animal model of ALS may represent a valid therapeutic target. Moreover, our data points toward novel research strategies such as investigating the role of oncogenic proteins in neurodegenerative diseases.

Cellular and molecular responses of zebrafish to legacy and emerging pollutants: the specific cases of PAHs and metal oxide nanoparticles

270 p.

Dietary animal and plant protein intakes and their associations with obesity and cardio-metabolic indicators in European adolescents: the HELENA cross-sectional study

Background: Previous studies suggest that dietary protein might play a beneficial role in combating obesity and its related chronic diseases. Total, animal and plant protein intakes and their associations with anthropometry and serum biomarkers in European adolescents using one standardised methodology across European countries are not well documented. Objectives: To evaluate total, animal and plant protein intakes in European adolescents stratified by gender and age, and to investigate their associations with cardio-metabolic indicators (anthropometry and biomarkers). Methods: The current analysis included 1804 randomly selected adolescents participating in the HELENA study (conducted in 2006-2007) aged 12.5-17.5 y (47% males) who completed two non-consecutive computerised 24-h dietary recalls. Associations between animal and plant protein intakes, and anthropometry and serum biomarkers were examined with General linear Model multivariate analysis. Results: Average total protein intake exceeded the recommendations of World Health Organization and European Food Safety Authority. Mean total protein intake was 96 g/d (59% derived from animal protein). Total, animal and plant protein intakes (g/d) were significantly lower in females than in males and total and plant protein intakes were lower in younger participants (12.5-14.9 y). Protein intake was significantly lower in underweight subjects and higher in obese ones; the direction of the relationship was reversed after adjustments for body weight (g/(kg.d)). The inverse association of plant protein intakes was stronger with BMI z-score and body fat percentage (BF%) compared to animal protein intakes. Additionally, BMI and BF% were positively associated with energy percentage of animal protein. Conclusions: This sample of European adolescents appeared to have adequate total protein intake. Our findings suggest that plant protein intakes may play a role in preventing obesity among European adolescents. Further longitudinal studies are needed to investigate the potential beneficial effects observed in this study in the prevention of obesity and related chronic diseases.