Unidades organizativas indígenas del área indoeuropea de Hispania III: addenda

[ES] Se ofrecen los nuevos nombres, repetidos o no, de unidades organizativas indígenas (cognationes, gentes y gentilitates) aparecidos desde la década de los 90 del pasado siglo y documentados en la epigrafía latina y celtibérica de la Hispania indoeuropea

Candida albicans Increases Tumor Cell Adhesion to Endothelial Cells In Vitro: Intraspecific Differences and Importance of the Mannose Receptor

The dimorphic fungus Candida albicans is able to trigger a cytokine-mediated pro-inflammatory response that increases tumor cell adhesion to hepatic endothelium and metastasis. To check the intraspecific differences in this effect, we used an in vitro murine model of hepatic response against C. albicans, which made clear that tumor cells adhered more to endothelium incubated with blastoconidia, both live and killed, than germ tubes. This finding was related to the higher carbohydrate/protein ratio found in blastoconidia. In fact, destruction of mannose ligand residues on the cell surface by metaperiodate treatment significantly reduced tumor cell adhesion induced. Moreover, we also noticed that the effect of clinical strains was greater than that of the reference one. This finding could not be explained by the carbohydrate/protein data, but to explain these differences between strains, we analyzed the expression level of ten genes (ADH1, APE3, IDH2, ENO1, FBA1, ILV5, PDI1, PGK1, QCR2 and TUF1) that code for the proteins identified previously in a mannoprotein-enriched pro-metastatic fraction of C. albicans. The results corroborated that their expression was higher in clinical strains than the reference one. To confirm the importance of the mannoprotein fraction, we also demonstrate that blocking the mannose receptor decreases the effect of C. albicans and its mannoproteins, inhibiting IL-18 synthesis and tumor cell adhesion increase by around 60%. These findings could be the first step towards a new treatment for solid organ cancers based on the role of the mannose receptor in C. albicans-induced tumor progression and metastasis.

Creación Colectiva. Teorías sobre la noción de autoría, modelos colaborativos de creación e implicaciones para la práctica y la educación del arte contemporáneo

Es una tesis muy extensa a propósito para probar la presencia e importancia del arte colaborativo a lo largo de la historia reciente y la necesidad de darle cabida en el terreno de la educación. No podemos seguir ignorando su potencial amparándonos en un concepto trasnochado y romántico de artista genial que trabaja en solitario. El arte está para muchas más cosas que la mera exposición y en un futuro cercano veremos trabajar en colaboración a artistas con expertos de muy distintas áreas de conocimiento.

[R_SanAsensio_Estrella] Levantamiento topográfico de la antigua hospedería y de los aposentos del arcediano. Estudio e integración de la cartografía existente. Monasterio de la Estrella (San Asensio, La Rioja)

[ES] La parte documentada consta de un edificio independiente (que no exento) que corresponde a la antigua hospedería, que tiene unas dimensiones de 25x15 metros y está formado por ocho espacios abovedados. En la fachada exterior Norte tiene adosada la denominada «Fuente de Felipe II». Por otro lado, los «aposentos del arcediano» consisten en una entrada al claustro por la conocida como «Puerta de los Caballeros» que es un espacio abovedado de 6 x 6 metros que da también acceso a una estancia rectangular de 12 x 6 metros que actualmente se utiliza como capilla. Este espacio cuenta también con varias vidrieras que también se han documentado.

Análisis del desarrollo de aplicaciones accesibles sobre el sistema operativo Android. Implementación de un sistema de barrido.

El objetivo principal de este proyecto es facilitar a aquellos usuarios con diversidades motrices el uso de sus dispositivos móviles con sistema Android a través de un barrido sobre la pantalla. Este barrido se realiza con dos ejes cartesianos que el usuario controla mediante cualquier periférico adaptado que posea y le permite decidir las coordenadas de la pantalla sobre las que desea interactuar.

[R_Casalarreina_Condestables] Documentación geométrica del Palacio de los Condestables de Casalarreina (La Rioja)

[ES] La documentación de este proyecto ha servido como base para la realización de los siguientes proyectos y artículos:

Ingeniaritzako proiektuak. Ariketak

Helburuak: Ingeniaritzako proiektuei buruzko zenbait ariketa bildu dira ikasmaterial honetan. Proiektuen oinarri teorikoak eta metodologikoak hainbat liburutan azaltzen direnez, ikuspegi praktiko bat proposatu da hemen. Mota askotako ariketak bildu dira, helburu espezifiko hauek betetzeko asmoz: oinarri teorikoak ezagutzea eta ulertzea, informazioa bilatzea, iragaztea eta analizatzea, kasuak ebaztea, erabakiak hartzea, hautaketak egitea, arrazoitzea, eta abar. Norentzat izan daiteke baliagarria: Ingeniaritzako ikasketetako proiektuen alorreko irakasgaien ikasle eta irakasleentzat da ariketa-bilduma hau. Nahiz eta energiako, meatzeetako eta obra zibileko ariketak erabili diren, proiektu teknikoetan interesik duen edonorentzat erabilgarria izan daiteke.

A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold

Proteolytic enzymes have evolved several mechanisms to cleave peptide bonds. These distinct types have been systematically categorized in the MEROPS database. While a BLAST search on these proteases identifies homologous proteins, sequence alignment methods often fail to identify relationships arising from convergent evolution, exon shuffling, and modular reuse of catalytic units. We have previously established a computational method to detect functions in proteins based on the spatial and electrostatic properties of the catalytic residues (CLASP). CLASP identified a promiscuous serine protease scaffold in alkaline phosphatases (AP) and a scaffold recognizing a beta-lactam (imipenem) in a cold-active Vibrio AP. Subsequently, we defined a methodology to quantify promiscuous activities in a wide range of proteins. Here, we assemble a module which encapsulates the multifarious motifs used by protease families listed in the MEROPS database. Since APs and proteases are an integral component of outer membrane vesicles (OMV), we sought to query other OMV proteins, like phospholipase C (PLC), using this search module. Our analysis indicated that phosphoinositide-specific PLC from Bacillus cereus is a serine protease. This was validated by protease assays, mass spectrometry and by inhibition of the native phospholipase activity of PI-PLC by the well-known serine protease inhibitor AEBSF (IC50 = 0.018 mM). Edman degradation analysis linked the specificity of the protease activity to a proline in the amino terminal, suggesting that the PI-PLC is a prolyl peptidase. Thus, we propose a computational method of extending protein families based on the spatial and electrostatic congruence of active site residues.

The Expanded mtDNA Phylogeny of the Franco-Cantabrian Region Upholds the Pre-Neolithic Genetic Substrate of Basques

9 p.

Clinical factors associated with a Candida albicans Germ Tube Antibody positive test in Intensive Care Unit patients

Background: Poor outcomes of invasive candidiasis (IC) are associated with the difficulty in establishing the microbiological diagnosis at an early stage. New scores and laboratory tests have been developed in order to make an early therapeutic intervention in an attempt to reduce the high mortality associated with invasive fungal infections. Candida albicans IFA IgG has been recently commercialized for germ tube antibody detection (CAGTA). This test provides a rapid and simple diagnosis of IC (84.4% sensitivity and 94.7% specificity). The aim of this study is to identify the patients who could be benefited by the use of CAGTA test in critical care setting. Methods: A prospective, cohort, observational multicentre study was carried out in six medical/surgical Intensive care units (ICU) of tertiary-care Spanish hospitals. Candida albicans Germ Tube Antibody test was performed twice a week if predetermined risk factors were present, and serologically demonstrated candidiasis was considered if the testing serum dilution was >= 1: 160 in at least one sample and no other microbiological evidence of invasive candidiasis was found. Results: Fifty-three critically ill non-neutropenic patients (37.7% post surgery) were included. Twenty-two patients (41.5%) had CAGTA-positive results, none of them with positive blood culture for Candida. Neither corrected colonization index nor antifungal treatment had influence on CAGTA results. This finding could corroborate that the CAGTA may be an important biomarker to distinguish between colonization and infection in these patients. The presence of acute renal failure at the beginning of the study was more frequent in CAGTA-negative patients. Previous surgery was statistically more frequent in CAGTA-positive patients. Conclusions: This study identified previous surgery as the principal clinical factor associated with CAGTA-positive results and emphasises the utility of this promising technique, which was not influenced by high Candida colonization or antifungal treatment. Our results suggest that detection of CAGTA may be important for the diagnosis of invasive candidiasis in surgical patients admitted in ICU.

Biologically-inspired data decorrelation for hyper-spectral imaging

Hyper-spectral data allows the construction of more robust statistical models to sample the material properties than the standard tri-chromatic color representation. However, because of the large dimensionality and complexity of the hyper-spectral data, the extraction of robust features (image descriptors) is not a trivial issue. Thus, to facilitate efficient feature extraction, decorrelation techniques are commonly applied to reduce the dimensionality of the hyper-spectral data with the aim of generating compact and highly discriminative image descriptors. Current methodologies for data decorrelation such as principal component analysis (PCA), linear discriminant analysis (LDA), wavelet decomposition (WD), or band selection methods require complex and subjective training procedures and in addition the compressed spectral information is not directly related to the physical (spectral) characteristics associated with the analyzed materials. The major objective of this article is to introduce and evaluate a new data decorrelation methodology using an approach that closely emulates the human vision. The proposed data decorrelation scheme has been employed to optimally minimize the amount of redundant information contained in the highly correlated hyper-spectral bands and has been comprehensively evaluated in the context of non-ferrous material classification

Algas verdes en el picoplancton y nanoplancton del estuario del río Nervión (Golfo de Vizcaya)

332 p. : il., gráf.

Effect of Molecular Flexibility on the Nematic-to-Isotropic Phase Transition for Highly Biaxial Molecular Non-Symmetric Liquid Crystal Dimers

In this work, a study of the nematic (N)-isotropic (I) phase transition has been made in a series of odd non-symmetric liquid crystal dimers, the alpha-(4-cyanobiphenyl-4'-yloxy)-omega-(1-pyrenimine-benzylidene-4'-oxy) alkanes, by means of accurate calorimetric and dielectric measurements. These materials are potential candidates to present the elusive biaxial nematic (N-B) phase, as they exhibit both molecular biaxiality and flexibility. According to the theory, the uniaxial nematic (N-U)-isotropic (I) phase transition is first-order in nature, whereas the N-B-I phase transition is second-order. Thus, a fine analysis of the critical behavior of the N-I phase transition would allow us to determine the presence or not of the biaxial nematic phase and understand how the molecular biaxiality and flexibility of these compounds influences the critical behavior of the N-I phase transition.

Aproximación al estudio de los contextos cerámicos del País Vasco, siglos XIV-XVII

Trabajo de Investigación Predoctoral 2006

Tracing the Basque presence in eastern Canada during the 16th and 17th centuries, through ceramic remains: the example of the glazed pottery produced in Bilbao

Poster presentado en Society for Post-Medieval Archaeology Conference, in St John's, Newfoundland,(Canadá)(June 2010)