Desarrollo de una herramienta virtual destinada al diseño de una plataforma robótica reconfigurable.

[ES]Este proyecto tiene como objeto aumentar el conocimiento concerniente a mecanismos robóticos reconfigurables, así como ponerlo en práctica. Estos mecanismos pueden lograr rápidas transiciones y son capaces de adaptarse a sí mismos a muchos entornos diferentes, conduciendo a una reducción de costes y requerimientos de espacio. Para ello, se estudia el estado del arte, de manera que se pueda reunir información sobre las principales aplicaciones y oportunidades que este campo ofrece en diferentes áreas. A continuación, se requiere llevar a cabo un análisis cinemático de un robot específico, y junto a métodos de planificación de trayectorias, su implementación en un software gráfico para simular su movimiento. La herramienta de software “Matlab” va a ser la que permitirá llevar a cabo toda la programación y representación a lo largo de todo el proyecto.

Celiac disease in the Mediterranean area

Background: The World Gastroenterology Organization recommends developing national guidelines for the diagnosis of Celiac Disease (CD): hence a profile of the diagnosis of CD in each country is required. We aim to describe a cross-sectional picture of the clinical features and diagnostic facilities in 16 countries of the Mediterranean basin. Since a new ESPGHAN diagnostic protocol was recently published, our secondary aim is to estimate how many cases in the same area could be identified without a small intestinal biopsy. Methods: By a stratified cross-sectional retrospective study design, we examined clinical, histological and laboratory data from 749 consecutive unselected CD children diagnosed by national referral centers. Results: The vast majority of cases were diagnosed before the age of 10 (median: 5 years), affected by diarrhea, weight loss and food refusal, as expected. Only 59 cases (7.8%) did not suffer of major complaints. Tissue transglutaminase (tTG) assay was available, but one-third of centers reported financial constraints in the regular purchase of the assay kits. 252 cases (33.6%) showed tTG values over 10 times the local normal limit. Endomysial antibodies and HLA typing were routinely available in only half of the centers. CD was mainly diagnosed from small intestinal biopsy, available in all centers. Based on these data, only 154/749 cases (20.5%) would have qualified for a diagnosis of CD without a small intestinal biopsy, according to the new ESPGHAN protocol. Conclusions: This cross-sectional study of CD in the Mediterranean referral centers offers a puzzling picture of the capacities to deal with the emerging epidemic of CD in the area, giving a substantive support to the World Gastroenterology Organization guidelines.

Adimen gaitasun handiko nesken ezaugarriak eta hauei laguntzeko prozedurak Haur Hezkuntzan: ekarpen didaktikoak

[eus] Adimen gaitasun handiko nesken egoera oso berezia da. Adimen gaitasun handi gisa, oso neska gutxi daude identifikatuta. Horren arrazoia, besteak beste nesken ezaugarriak, portaerak, jasotzen duten hezkuntza eta inguratzen dituen gizartea dira. Hori dela eta, irakasleen lana arlo honetan oso garrantzitsua da. Horrexegatik, lan honen helburua, irakasleei eta familiei laguntzeko ekarpen didaktikoak sortzea izan da. Alde batetik, neska hauen ezaugarriak eta hauei laguntzeko zenbait prozedura azaltzen dituen bideoa sortu da, bestetik, neska hauek identifikatzeko eta laguntzeko behaketa-tresna proposatu da.

Fluidic flow delay by ionogel passive pumps in microfluidicpaper-based analytical devices

[EN] A new concept for fluid flow manipulation in microfluidic paper-based analytical devices ( µPADs) is presented by introducing ionogel materials as passive pumps. µPADs were fabricated using a new doubleside contact stamping process and ionogels were precisely photopolymerised at the inlet of the µPADs.The ionogels remain mainly on the surface of the paper and get absorbed in the superficial paper-fibers allowing for the liquid to flow from the ionogel into the paper easily. As a proof of concept the fluid flow and mixing behaviour of two different ionogels µPADs were compared with the non-treated µPADs.It was demonstrated that both ionogels highly affect the fluid flow by delaying the flow due to their different physical and chemical properties and water holding capacities.

Sensing parasites: proteomic and advanced bio-detection alternatives

[EN] Parasitic diseases have a great impact in human and animal health. The gold standard for the diagnosis of the majority of parasitic infections is still conventional microscopy, which presents important limitations in terms of sensitivity and specificity and commonly requires highly trained technicians. More accurate molecular-based diagnostic tools are needed for the implementation of early detection, effective treatments and massive screenings with high-throughput capacities. In this respect, sensitive and affordable devices could greatly impact on sustainable control programmes which exist against parasitic diseases, especially in low income settings. Proteomics and nanotechnology approaches are valuable tools for sensing pathogens and host alteration signatures within microfluidic detection platforms. These new devices might provide novel solutions to fight parasitic diseases. Newly described specific parasite derived products with immune-modulatory properties have been postulated as the best candidates for the early and accurate detection of parasitic infections as well as for the blockage of parasite development. This review provides the most recent methodological and technological advances with great potential for biosensing parasites in their hosts, showing the newest opportunities offered by modern “-omics” and platforms for parasite detection and control.