Is there a subgroup of long-term evolution among patients with advanced lung cancer?: Hints from the analysis of survival curves from cancer registry data

Background: Recently, with the access of low toxicity biological and targeted therapies, evidence of the existence of a long-term survival subpopulation of cancer patients is appearing. We have studied an unselected population with advanced lung cancer to look for evidence of multimodality in survival distribution, and estimate the proportion of long-term survivors. Methods: We used survival data of 4944 patients with non-small-cell lung cancer (NSCLC) stages IIIb-IV at diagnostic, registered in the National Cancer Registry of Cuba (NCRC) between January 1998 and December 2006. We fitted one-component survival model and two-component mixture models to identify short-and long-term survivors. Bayesian information criterion was used for model selection. Results: For all of the selected parametric distributions the two components model presented the best fit. The population with short-term survival (almost 4 months median survival) represented 64% of patients. The population of long-term survival included 35% of patients, and showed a median survival around 12 months. None of the patients of short-term survival was still alive at month 24, while 10% of the patients of long-term survival died afterwards. Conclusions: There is a subgroup showing long-term evolution among patients with advanced lung cancer. As survival rates continue to improve with the new generation of therapies, prognostic models considering short-and long-term survival subpopulations should be considered in clinical research.

Pharmacogenetics of MicroRNAs and MicroRNAs Biogenesis Machinery in Pediatric Acute Lymphoblastic Leukemia

Despite the clinical success of acute lymphoblastic leukemia (ALL) therapy, toxicity is frequent. Therefore, it would be useful to identify predictors of adverse effects. In the last years, several studies have investigated the relationship between genetic variation and treatment-related toxicity. However, most of these studies are focused in coding regions. Nowadays, it is known that regions that do not codify proteins, such as microRNAs (miRNAs), may have an important regulatory function. MiRNAs can regulate the expression of genes affecting drug response. In fact, the expression of some of those miRNAs has been associated with drug response. Genetic variations affecting miRNAs can modify their function, which may lead to drug sensitivity. The aim of this study was to detect new toxicity markers in pediatric B-ALL, studying miRNA-related polymorphisms, which can affect miRNA levels and function. We analyzed 118 SNPs in pre-miRNAs and miRNA processing genes in association with toxicity in 152 pediatric B-ALL patients all treated with the same protocol (LAL/SHOP). Among the results found, we detected for the first time an association between rs639174 in DROSHA and vomits that remained statistically significant after FDR correction. DROSHA had been associated with alterations in miRNAs expression, which could affect genes involved in drug transport. This suggests that miRNA-related SNPs could be a useful tool for toxicity prediction in pediatric B-ALL.

Revisión sistemática y metanálisis multivariado de la eficacia de potenciadores cognitivos en esquizofrenia

[287]p.

Transcripción de la conversación por teletipo mantenida por el Presidente de Euzkadi y los militares republicanos Belarmino Tomás y Francisco Ciutat sobre diversos aspectos de la campaña del Norte

Sin fecha (1937)/ Unidad de ínstalación: Carpeta Rectorado - B-2 / Nº de hojas: 2. Mecanografiado

Transcripción de la conversación por teletipo entre el Presidente de Euzkadi y Francisco Ciutat con relación al estado de la guerra

Sin fecha (1937) / Unidad de ínstalación: Carpeta Rectorado - B-3 / Nº de pág.: 1 (mecanografiada)

Transcripción de la conversación por teletipo entre los militares republicanos Belarmino Tomás y Francisco Ciutat con el Presidente de Euzkadi con relación a noticias sobre el frente

Sin fecha (1937) / Unidad de ínstalación: Carpeta Rectorado - B-4 / Nº de pág.: 1. Mecanografiada

Transcripción de la conversación con teletipo entre Francisco Ciutat y el Presidente de Euzkadi con relación al estado de la Guerra Civil

Sin fecha (1937) / Unidad de ínstalación: Carpeta Rectorado - B-5 y 6 / Nº de pág.: 1 (escrita por las dos caras). Mecanografiada