18 resultados para Augmented Dice


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[EUS] Lan honetan aurkikuntza baten berri ematen dugu: Plentziako armarri batean aurkitutako hiru euskal esaera zahar (1603) aurkezten eta hizkuntzaren eta historiaren ikuspuntutik aztertzen ditugu. Hiru esaerotatik bi «Refranes y sentencias» 1596) lanean agertzen dira, eta hori datu garrantzitsua da; izan ere, Lakarrak 1996) errefrau-bilduma anonimo horren jatorriaz egindako proposamena berresteko argudio berria da. Zehazki, Bizkaiko ipar-mendebala proposatu zuen Lakarrak bildumako errefrauen jatorri gisa. Beste alde batetik, Bizkaiko ipar-mendebaleko euskararen zenbait ezaugarri baliatuta, Arrasateko erreketari buruzko zenbait kantu eremu horretan sortu zirela proposatzen dugu —zehazki, Butroeko (Gatika) dorretxearen inguruan—, hizkuntzari dagozkion argudioak historiari buruzkoekin osatuta.

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Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson's disease (PD) and psychiatric disorders. L-DOPA, the leading treatment of PD, facilitates the production and release of dopamine. This study assessed the action of L-DOPA on monoamine synaptic transmission in mouse brain slices. Application of L-DOPA augmented the D2-receptor-mediated inhibitory postsynaptic current (IPSC) in dopamine neurons of the substantia nigra. This augmentation was largely due to dopamine release from 5-HT terminals. Selective optogenetic stimulation of 5-HT terminals evoked dopamine release, producing D2-receptor-mediated IPSCs following treatment with L-DOPA. In the dorsal raphe, L-DOPA produced a long-lasting depression of the 5-HT1A-receptor-mediated IPSC in 5-HT neurons. When D2 receptors were expressed in the dorsal raphe, application of L-DOPA resulted in a D2-receptor-mediated IPSC. Thus, treatment with L-DOPA caused ectopic dopamine release from 5-HT terminals and a loss of 5-HT-mediated synaptic transmission.