104 resultados para Alba, José Álvarez de Toledo , Duque de-Panegírics


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Providing on line travel time information to commuters has become an important issue for Advanced Traveler Information Systems and Route Guidance Systems in the past years, due to the increasing traffic volume and congestion in the road networks. Travel time is one of the most useful traffic variables because it is more intuitive than other traffic variables such as flow, occupancy or density, and is useful for travelers in decision making. The aim of this paper is to present a global view of the literature on the modeling of travel time, introducing crucial concepts and giving a thorough classification of the existing tech- niques. Most of the attention will focus on travel time estimation and travel time prediction, which are generally not presented together. The main goals of these models, the study areas and methodologies used to carry out these tasks will be further explored and categorized.

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Eguíluz, Federico; Merino, Raquel; Olsen, Vickie; Pajares, Eterio; Santamaría, José Miguel (eds.)

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[EN] This contribution offers a brief overview of research undertaken for the last few years under the TRACE (translation and censorship, or censored translations) project with respect to theatre. The AGA (General Administration Archive in Alcala de Henares, Madrid), a unique source for information for translation scholars, has become the focus of TRACE-theatre investigations on Francoist Spain in the last few years. In Spain, these censorship archives have proved to be an essential source of information, and a rich reservoir of data that, when explored in depth, help draw a history of Spanish theatre in translation. Contrary to what one may think at first, the purpose of using censorship archives in TRACE is not only to check what got censored (banned, crossed out or modified) but rather to trace back all written evidence left by plays that underwent the bureaucratic censoring process which was applied to all cultural manifestations, national or foreign, theatrical as well as non-dramatic. And it is precisely when tracing back censorship records that one finds a way to uncover a history of Spanish theatre in translation that is yet to be written but can now be outlined.

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El tema que vamos a desarrollar se orienta a la satisfacción y fidelización de la clientela como objetivo esencial de la empresa, lo que pemitirá aumentar la competitividad y pilotar la organización por la senda de la máxima eficiencia posible, en un enfoque sistématico de mejora continua hacia la excelencia empresarial.

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[ES] El área de trabajo ocupa unos 60 x 60 metros y está situada en la cima del monte Aitz Txiki (Astxiki) en la que se aprecian algunos restos de muros y un aljibe, pertenecientes a una construcción defensiva.

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[ES] El conjunto está formado por la torre de Martiartu (de unas 16 x 16 metros de planta), la pequeña ermita de la San Antonio y el área circundante.

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Background The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a humanized monoclonal antibody that recognizes the EGFR extracellular domain and reaches Central Nervous System tumors, in nonclinical and clinical setting. While it has similar activity when compared to other anti-EGFR antibodies, it does not induce skin toxicity or hypomagnesemia. Methods A randomized, double blind, multicentric clinical trial was conducted in high grade glioma patients (41 anaplastic astrocytoma and 29 glioblastoma multiforme) that received radiotherapy plus nimotuzumab or placebo. Treatment and placebo groups were well-balanced for the most important prognostic variables. Patients received 6 weekly doses of 200 mg nimotuzumab or placebo together with irradiation as induction therapy. Maintenance treatment was given for 1 year with subsequent doses administered every 3 weeks. The objectives of this study were to assess the comparative overall survival, progression free survival, response rate, immunogenicity and safety. Results The median cumulative dose was 3200 mg of nimotuzumab given over a median number of 16 doses. The combination of nimotuzumab and RT was well-tolerated. The most prevalent related adverse reactions included nausea, fever, tremors, anorexia and hepatic test alteration. No anti-idiotypic response was detected, confirming the antibody low immunogenicity. The mean and median survival time for subjects treated with nimotuzumab was 31.06 and 17.76 vs. 21.07 and 12.63 months for the control group. Conclusions In this randomized trial, nimotuzumab showed an excellent safety profile and significant survival benefit in combination with irradiation.

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Eterio Pajares, Raquel Merino y José Miguel Santamaría (eds.)

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Eterio Pajares, Raquel Merino y José Miguel Santamaría (eds.)

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Eterio Pajares, Raquel Merino y José Miguel Santamaría (eds.)

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Raquel Merino Álvarez, José Miguel Santamaría, Eterio Pajares (eds.)

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Raquel Merino Álvarez, José Miguel Santamaría, Eterio Pajares (eds.)

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Raquel Merino Álvarez, José Miguel Santamaría, Eterio Pajares (eds.)

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Raquel Merino Álvarez, José Miguel Santamaría, Eterio Pajares (eds.)