1 resultado para Muscle and tibiotarsus
em Universita di Parma
Filtro por publicador
- ABACUS. Repositorio de Producción Científica - Universidad Europea (4)
- Abertay Research Collections - Abertay University’s repository (3)
- Academic Archive On-line (Mid Sweden University; Sweden) (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (4)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (7)
- Aquatic Commons (28)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (5)
- Aston University Research Archive (39)
- Biblioteca de Teses e Dissertações da USP (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (27)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (21)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (9)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (47)
- Boston University Digital Common (2)
- Brock University, Canada (5)
- Cambridge University Engineering Department Publications Database (8)
- CentAUR: Central Archive University of Reading - UK (17)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (32)
- Cochin University of Science & Technology (CUSAT), India (3)
- Coffee Science - Universidade Federal de Lavras (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (5)
- Deakin Research Online - Australia (91)
- Digital Commons - Michigan Tech (2)
- Digital Commons at Florida International University (3)
- Digital Repository at Iowa State University (2)
- DigitalCommons@The Texas Medical Center (10)
- Duke University (8)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (5)
- Glasgow Theses Service (1)
- Greenwich Academic Literature Archive - UK (1)
- Helda - Digital Repository of University of Helsinki (21)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (13)
- Instituto Politécnico de Viseu (2)
- Instituto Politécnico do Porto, Portugal (1)
- Massachusetts Institute of Technology (1)
- National Center for Biotechnology Information - NCBI (51)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (7)
- Publishing Network for Geoscientific & Environmental Data (2)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (58)
- Queensland University of Technology - ePrints Archive (104)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (2)
- Repositório Institucional da Universidade Federal de São Paulo - UNIFESP (1)
- Repositório Institucional da Universidade Federal do Rio Grande - FURG (4)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (189)
- SAPIENTIA - Universidade do Algarve - Portugal (4)
- South Carolina State Documents Depository (1)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (2)
- Universidad Politécnica de Madrid (1)
- Universidade Complutense de Madrid (2)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Federal do Pará (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (9)
- Universita di Parma (1)
- Universitat de Girona, Spain (1)
- Université de Lausanne, Switzerland (3)
- Université de Montréal, Canada (7)
- Université Laval Mémoires et thèses électroniques (1)
- University of Connecticut - USA (2)
- University of Michigan (3)
- University of Queensland eSpace - Australia (19)
- WestminsterResearch - UK (2)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
The aging myopathy manifests itself with diastolic dysfunction and preserved ejection fraction. However, the difficulty in defining myocardial aging and the mechanisms involved complicates the recognition of the cellular processes underlying impaired diastolic relaxation. We raised the possibility that, in a mouse model of physiological aging, defects in the electromechanical properties of cardiomyocytes are important determinants of the diastolic properties of the myocardium, independently from changes in the structural composition of the muscle and collagen framework. Here we show that an increase in the late Na+ current (INaL) in aging cardiomyocytes prolongs the action potential (AP) and influences the temporal kinetics of Ca2+ cycling and cell shortening. These alterations increase force development and passive tension. Inhibition of INaL shortens the AP and corrects the dynamics of Ca2+ transient, cell contraction and relaxation. Similarly, repolarization and diastolic tension of the senescent myocardium are partly restored. INaL offers inotropic support, but negatively interferes with cellular and ventricular compliance, providing a new perspective of the biology of myocardial aging and the etiology of the defective cardiac performance in the elderly.