1 resultado para RNA viral
em Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer
Filtro por publicador
- University of Cagliari UniCA Eprints (1)
- Aberystwyth University Repository - Reino Unido (1)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- Adam Mickiewicz University Repository (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (4)
- Aquatic Commons (3)
- ARCA - Repositório Institucional da FIOCRUZ (4)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (5)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (13)
- Aston University Research Archive (2)
- B-Digital - Universidade Fernando Pessoa - Portugal (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (5)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (1)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (28)
- Brock University, Canada (10)
- CaltechTHESIS (13)
- Cambridge University Engineering Department Publications Database (7)
- CentAUR: Central Archive University of Reading - UK (35)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (91)
- Cochin University of Science & Technology (CUSAT), India (4)
- CORA - Cork Open Research Archive - University College Cork - Ireland (3)
- Deakin Research Online - Australia (20)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (2)
- Digital Commons at Florida International University (1)
- DigitalCommons@The Texas Medical Center (14)
- DigitalCommons@University of Nebraska - Lincoln (1)
- DRUM (Digital Repository at the University of Maryland) (5)
- Duke University (26)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (22)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Greenwich Academic Literature Archive - UK (1)
- Helda - Digital Repository of University of Helsinki (41)
- Indian Institute of Science - Bangalore - Índia (136)
- Instituto Gulbenkian de Ciência (1)
- National Center for Biotechnology Information - NCBI (58)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (19)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (121)
- Queensland University of Technology - ePrints Archive (105)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (2)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositorio Institucional de la Universidad Pública de Navarra - Espanha (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (39)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- SAPIENTIA - Universidade do Algarve - Portugal (3)
- School of Medicine, Washington University, United States (3)
- Universidad Autónoma de Nuevo León, Mexico (12)
- Universidad del Rosario, Colombia (5)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (4)
- Universidade Federal do Pará (13)
- Universidade Federal do Rio Grande do Norte (UFRN) (1)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (7)
- Université de Lausanne, Switzerland (10)
- Université de Montréal, Canada (39)
- University of Connecticut - USA (1)
- University of Queensland eSpace - Australia (11)
- University of Washington (1)
- WestminsterResearch - UK (4)
Resumo:
Archaeal replicative DNA polymerase D (PolD) constitute an atypical class of DNA polymerases made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2), both with unknown structures. We have determined the crystal structures of Pyrococcus abyssi DP1 and DP2 at 2.5 and 2.2 angstrom resolution, respectively, revealing a catalytic core strikingly different from all other known DNA polymerases (DNAPs). Rather, the PolD DP2 catalytic core has the same 'double-psi beta-barrel' architecture seen in the RNA polymerase (RNAP) superfamily, which includes multi-subunit transcriptases of all domains of life, homodimeric RNA-silencing pathway RNAPs and atypical viral RNAPs. This finding bridges together, in non-viral world, DNA transcription and DNA replication within the same protein superfamily. This study documents further the complex evolutionary history of the DNA replication apparatus in different domains of life and proposes a classification of all extant DNAPs.