1 resultado para One-author literary journals
em Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer
Filtro por publicador
- JISC Information Environment Repository (5)
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Aberdeen University (2)
- Aberystwyth University Repository - Reino Unido (1)
- Academic Archive On-line (Jönköping University; Sweden) (1)
- Academic Research Repository at Institute of Developing Economies (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (2)
- Adam Mickiewicz University Repository (5)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (7)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (4)
- Andina Digital - Repositorio UASB-Digital - Universidade Andina Simón Bolívar (6)
- Aquatic Commons (3)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (2)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (77)
- Aston University Research Archive (12)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (5)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (3)
- Biblioteca Digital de la Universidad Católica Argentina (2)
- Biblioteca Digital de la Universidad del Valle - Colombia (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (20)
- Blue Tiger Commons - Lincoln University - USA (9)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (17)
- Brock University, Canada (3)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- Bulgarian Digital Mathematics Library at IMI-BAS (2)
- Cambridge University Engineering Department Publications Database (1)
- CentAUR: Central Archive University of Reading - UK (11)
- Center for Jewish History Digital Collections (1)
- Central European University - Research Support Scheme (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (1)
- Coffee Science - Universidade Federal de Lavras (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (6)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- CUNY Academic Works (1)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (49)
- Digital Commons - Michigan Tech (1)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (6)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- Duke University (5)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- Greenwich Academic Literature Archive - UK (1)
- Harvard University (1)
- Helda - Digital Repository of University of Helsinki (19)
- Indian Institute of Science - Bangalore - Índia (11)
- Institutional Repository of Leibniz University Hannover (2)
- Instituto Politécnico de Viseu (1)
- Instituto Politécnico do Porto, Portugal (2)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (2)
- Memoria Académica - FaHCE, UNLP - Argentina (30)
- National Center for Biotechnology Information - NCBI (2)
- Nottingham eTheses (1)
- Portal de Revistas Científicas Complutenses - Espanha (44)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (11)
- Queensland University of Technology - ePrints Archive (234)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório Científico da Universidade de Évora - Portugal (2)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositorio de la Universidad de Cuenca (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade de Brasília (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (63)
- Repositorio Institucional Universidad de Medellín (1)
- Research Open Access Repository of the University of East London. (2)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (2)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (3)
- Universidad Politécnica de Madrid (7)
- Universidade Complutense de Madrid (6)
- Universidade Federal do Pará (7)
- Universidade Federal do Rio Grande do Norte (UFRN) (4)
- Universidade Metodista de São Paulo (3)
- Universidade Técnica de Lisboa (1)
- Universitat de Girona, Spain (1)
- Université de Montréal, Canada (26)
- University of Canberra Research Repository - Australia (1)
- University of Connecticut - USA (2)
- University of Michigan (78)
- University of Queensland eSpace - Australia (4)
- University of Southampton, United Kingdom (1)
- University of Washington (3)
Resumo:
Collagen VI (COLVI), a protein ubiquitously expressed in connective tissues, is crucial for structural integrity, cellular adhesion, migration and survival. Six different genes are recognized in mammalians, encoding six COLVI-chains that assemble as two ‘short’ (α1, α2) and one ‘long’ chain (theoretically any one of α3–6). In humans, defects in the most widely expressed heterotrimer (α123), due to mutations in the COL6A1-3 genes, cause a heterogeneous group of neuromuscular disorders, collectively termed COLVI-related muscle disorders. Little is known about the function(s) of the recently described α4-6 chains and no mutations have been detected yet. In this study, we characterized two novel COLVI long chains in zebrafish that are most homologous to the mammalian α4 chain; therefore, we named the corresponding genes col6a4a and col6a4b. These orthologues represent ancestors of the mammalian Col6a4-6 genes. By in situ hybridization and RT-qPCR, we unveiled a distinctive expression kinetics for col6a4b, compared with the other col6a genes. Using morpholino antisense oligonucleotides targeting col6a4a, col6a4b and col6a2, we modelled partial and complete COLVI deficiency, respectively. All morphant embryos presented altered muscle structure and impaired motility. While apoptosis was not drastically increased, autophagy induction was defective in all morphants. Furthermore, motoneuron axon growth was abnormal in these morphants. Importantly, some phenotypical differences emerged between col6a4a and col6a4b morphants, suggesting only partial functional redundancy. Overall, our results further confirm the importance of COLVI in zebrafish muscle development and may provide important clues for potential human phenotypes associated with deficiency of the recently described COLVI-chains.