61 resultados para MALARIA VECTORS
Filtro por publicador
- KUPS-Datenbank - Universität zu Köln - Kölner UniversitätsPublikationsServer (1)
- Repository Napier (1)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- Academic Research Repository at Institute of Developing Economies (2)
- Aquatic Commons (9)
- ARCA - Repositório Institucional da FIOCRUZ (4)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archive of European Integration (16)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (3)
- Aston University Research Archive (4)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (39)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (25)
- Bioline International (7)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (53)
- Boston University Digital Common (1)
- Brock University, Canada (3)
- Bulgarian Digital Mathematics Library at IMI-BAS (2)
- CaltechTHESIS (2)
- Cambridge University Engineering Department Publications Database (5)
- CentAUR: Central Archive University of Reading - UK (21)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (4)
- Coffee Science - Universidade Federal de Lavras (1)
- Collection Of Biostatistics Research Archive (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (2)
- CORA - Cork Open Research Archive - University College Cork - Ireland (4)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (2)
- Dalarna University College Electronic Archive (3)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons - Michigan Tech (1)
- Digital Commons at Florida International University (1)
- Digital Knowledge Repository of Central Drug Research Institute (1)
- DigitalCommons@The Texas Medical Center (12)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (7)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- Duke University (12)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (18)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (1)
- Helda - Digital Repository of University of Helsinki (18)
- Indian Institute of Science - Bangalore - Índia (84)
- Instituto Gulbenkian de Ciência (1)
- Instituto Politécnico do Porto, Portugal (1)
- National Center for Biotechnology Information - NCBI (61)
- Nottingham eTheses (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (3)
- Publishing Network for Geoscientific & Environmental Data (1)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (20)
- Queensland University of Technology - ePrints Archive (239)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (2)
- Repositório Científico da Universidade de Évora - Portugal (2)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (2)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (48)
- Research Open Access Repository of the University of East London. (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (7)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- Scielo España (1)
- Scientific Open-access Literature Archive and Repository (1)
- South Carolina State Documents Depository (1)
- Universidad Autónoma de Nuevo León, Mexico (1)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (4)
- Universidad Politécnica de Madrid (9)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (4)
- Universidade de Madeira (1)
- Universidade Federal do Pará (8)
- Universidade Federal do Rio Grande do Norte (UFRN) (2)
- Universitat de Girona, Spain (1)
- Université de Lausanne, Switzerland (8)
- Université de Montréal (1)
- Université de Montréal, Canada (2)
- Université Laval Mémoires et thèses électroniques (1)
- University of Michigan (28)
- University of Queensland eSpace - Australia (35)
- University of Southampton, United Kingdom (2)
- University of Washington (4)
- WestminsterResearch - UK (1)
Resumo:
Immunization of rodents and humans with irradiation-attenuated malaria sporozoites confers preerythrocytic stage-specific protective immunity to challenge infection. This immunity is directed against intrahepatic parasites and involves T cells and interferon gamma, which prevent development of exoerythrocytic stages and subsequent blood infection. The present study was undertaken to determine how protective immunity is achieved after immunization of rodent hosts with irradiated Plasmodium berghei sporozoites. We present evidence that irradiated parasites persist in hepatocytes of rats and mice for up to 6 months after immunization. A relationship between the persistence of parasites and the maintenance of protective immunity was observed. Protective immunity was abrogated in irradiated-sporozoite-immunized rats following the application of chemotherapy to remove preexisting liver parasites. Additionally, protective immunity against sporozoite challenge was established in rats vaccinated with early and late hepatic stages of irradiated parasites. These results show that irradiation-attenuated sporozoites produce persistent intrahepatic stages in vivo necessary for the induction and maintenance of protective immunity.