16 resultados para 5-METHYL-5-BENZYLOXYCARBONYL-1
Filtro por publicador
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Campus - Alm@DL - Università di Bologna (4)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (1)
- Aquatic Commons (5)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (4)
- Archive of European Integration (9)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (1)
- Aston University Research Archive (11)
- Biblioteca de Teses e Dissertações da USP (4)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (22)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (10)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Bibloteca do Senado Federal do Brasil (7)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (21)
- Brock University, Canada (4)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- CaltechTHESIS (3)
- Cambridge University Engineering Department Publications Database (2)
- CentAUR: Central Archive University of Reading - UK (20)
- Center for Jewish History Digital Collections (7)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (89)
- Cochin University of Science & Technology (CUSAT), India (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Deakin Research Online - Australia (10)
- Digital Commons - Michigan Tech (1)
- Digital Commons - Montana Tech (2)
- Digital Commons @ Winthrop University (1)
- Digital Commons at Florida International University (2)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (4)
- DigitalCommons@University of Nebraska - Lincoln (2)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (12)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (17)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (5)
- Greenwich Academic Literature Archive - UK (1)
- Harvard University (14)
- Helda - Digital Repository of University of Helsinki (21)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (225)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (2)
- Instituto Nacional de Saúde de Portugal (1)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (3)
- National Center for Biotechnology Information - NCBI (16)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- Publishing Network for Geoscientific & Environmental Data (118)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (15)
- Queensland University of Technology - ePrints Archive (133)
- Repositorio Academico Digital UANL (2)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade Federal do Rio Grande - FURG (1)
- Repositorio Institucional de la Universidad Nacional Agraria (17)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (64)
- Repositorio Institucional Universidad de Medellín (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (1)
- School of Medicine, Washington University, United States (1)
- Scielo Uruguai (1)
- South Carolina State Documents Depository (1)
- Universidad Autónoma de Nuevo León, Mexico (1)
- Universidad de Alicante (4)
- Universidad del Rosario, Colombia (3)
- Universidad Politécnica de Madrid (2)
- Universidade Complutense de Madrid (2)
- Universidade Federal do Pará (2)
- Universidade Federal do Rio Grande do Norte (UFRN) (1)
- Universidade Metodista de São Paulo (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (4)
- Université de Lausanne, Switzerland (1)
- Université de Montréal, Canada (4)
- University of Michigan (9)
- University of Queensland eSpace - Australia (9)
Resumo:
Extracellular human immunodeficiency virus type 1 (HIV-1) Tat protein promotes growth of spindle cells derived from AIDS-associated Kaposi sarcoma (AIDS-KS), an angioproliferative disease very frequent in HIV-1-infected individuals. Normal vascular cells, progenitors of AIDS-KS cells, proliferate in response to Tat after exposure to inflammatory cytokines, whose levels are augmented in HIV-1-infected individuals and in KS lesions. Here we show that Tat also promotes AIDS-KS and normal vascular cells to migrate and to degrade the basement membrane and stimulates endothelial cell morphogenesis on a matrix substrate. These effects are obtained at picomolar concentrations of exogenous Tat and are promoted by the treatment of the cells with the same inflammatory cytokines stimulating expression of the receptors for Tat, the integrins alpha 5 beta 1 and alpha v beta 3. Thus, under specific circumstances, Tat has angiogenic properties. As Tat and its receptors are present in AIDS-KS lesions, these data may explain some of the mechanisms by which Tat can induce angiogenesis and cooperate in the development of AIDS-KS.