Comparison of the traditional pharmaceutical validation method versus an assisted pharmaceutical validation in hospitalized patients

Objective: To analyze pharmaceutical interventions that have been carried out with the support of an automated system for validation of treatments vs. the traditional method without computer support. Method: The automated program, ALTOMEDICAMENTOS® version 0, has 925 052 data with information regarding approximately 20 000 medicines, analyzing doses, administration routes, number of days with such a treatment, dosing in renal and liver failure, interactions control, similar drugs, and enteral medicines. During eight days, in four different hospitals (high complexity with over 1 000 beds, 400-bed intermediate, geriatric and monographic), the same patients and treatments were analyzed using both systems. Results: 3,490 patients were analyzed, with 42 155 different treatments. 238 interventions were performed using the traditional system (interventions 0.56% / possible interventions) vs. 580 (1.38%) with the automated one. Very significant pharmaceutical interventions were 0.14% vs. 0.46%; significant was 0.38% vs. 0.90%; non-significant was 0.05% vs. 0.01%, respectively. If both systems are simultaneously used, interventions are performed in 1.85% vs. 0.56% with just the traditional system. Using only the traditional model, 30.5% of the possible interventions are detected, whereas without manual review and only the automated one, 84% of the possible interventions are detected. Conclusions: The automated system increases pharmaceutical interventions between 2.43 to 3.64 times. According to the results of this study the traditional validation system needs to be revised relying on automated systems. The automated program works correctly in different hospitals.

Using autologous platelet-rich plasma for the treatment of complex fistulas

Objective: This study aims to demonstrate the effectiveness and safety of autologous fibrin gel rich in platelet growth factors for the treatment of complex perianal fistulas. Material and methods: Prospective epidemiological study. Patients with complex perianal fistula or perianal fistula mere alteration of continence are included. identification of both holes and the journey, curettage of it and instillation of Vivostat PRF® in the way it is done to observe excess material by OFE. The variables analyzed were: age, sex, use of prior Seton clinic prevalent type of fistula, postoperative complications, fistula closure and impaired quality of life using the SF-36 test (v2). Results: From January 2011 to May 2013 have involved 23 patients, 12 men and 11 women, with an average age of 49 years and a minimum follow-up of 12 months. Two dropped out. 17 patients had low transsphincteric fistulas, 2 and 2 high transsphincteric intersphincteric with impaired continence. The most common symptom is the discharge. Twelve patients had a loose seton (62%), of which nine cured. Of all the patients we have operated the success rate is 62%. No patient developed incontinence after treatment. Only two reported a worse quality of life after surgery. Conclusion: This study demonstrates that there is a clear benefit to the use of Vivostat PRF® as a treatment for complex perianal fistulas. It is a highly reproducible technique with acceptable results and does not produce impairment of continence.

Efecto de 12 sesiones de un entrenamiento interválico de alta intensidad sobre la composición corporal en adultos jóvenes

Introducción: actualmente los programas de entrenamiento interválicos de alta intensidad parecen ser una forma de optimizar el tiempo, provocando cambios en la composición corporal debido a la activación de diferentes mecanismos hormonales y metabólicos. Objetivo: observar el efecto de cuatro semanas de entrenamiento de esprints repetidos basados en la prueba de Wingate sobre la potencia y la composición corporal en adultos jóvenes. Métodos: los participantes (22,4 ± 1,8 años) fueron asignados aleatoriamente a un grupo experimental o a un grupo control. Antes de comenzar y al acabar el periodo experimental, a los sujetos se les realizó una densitometría de cuerpo completo y una prueba de Wingate. El grupo experimental realizó 12 sesiones de esprints repetidos, realizando de 3 a 6 esprints de 30 segundos con un tiempo de recuperación de 4 minutos. El grupo control continuó con su rutina diaria y no se le aplicó ningún tipo de intervención. Resultados: en el grupo experimental, la potencia media y máxima incrementó un 9,4-16,5% (p < 0,001). Además, disminuyó la masa grasa total un 8,1% (p < 0,028) y la grasa abdominal un 10,0% (p < 0,038). El grupo control no sufrió cambios en ninguna de las variables estudiadas. Conclusiones: cuatro semanas de entrenamiento de esprints repetidos basados en la prueba de Wingate con un volumen específico de ~3 minutos por sesión y una frecuencia de 3 sesiones por semana, muestra mejoras estadísticamente significativas en la potencia máxima y media. Además, provoca cambios en la composición corporal, principalmente en la masa grasa total y de la zona abdominal.