6 resultados para biochemical and ultrastructural changes

em Universidad Politécnica de Madrid


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Observation has widely shown for nearly all last century that the Spanish (Dynamic) Maritime Climate was following around 10 to 11 year cycles in its most significant figure, wind wave, despite it being better to register cycles of 20 to 22 years, in analogical way with the semi-diurnal and diurnal cycles of Cantabrian tides. Those cycles were soon linked to sun activity and, at the end of the century, the latter was related to the Solar System evolution. We know now that waves and storm surges are coupled and that (Dynamic) Maritime Climate forms part of a more complex “Thermal Machine” including Hydrological cycle. The analysis of coastal floods could so facilitate the extension of that experience. According to their immediate cause, simple flood are usually sorted out into flash, pluvial, fluvial, groundwater and coastal types, considering the last as caused by sea waters. But the fact is that most of coastal floods are the result of the concomitance of several former simple types. Actually, the several Southeastern Mediterranean coastal flood events show to be the result of the superposition within the coastal zone of flash, fluvial, pluvial and groundwater flood types under boundary condition imposed by the concomitant storm sea level rise. This work shall be regarded as an attempt to clarify that cyclic experience, through an in-depth review of a past flood events in Valencia (Turia and Júcar basins), as in Murcia (Segura’s) as well.

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The well-known eponym El Sidrón has a very special history. It started with the development of a karstic system between two types of rock (sandstone and Neogene conglomerates) as a result of the flow of a small stream. It continued with the use of the cave as a refuge and a hiding place during the Spanish Civil War and the aftermath and with the presence of some endemic species of bats and cave insects

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Impact response surfaces (IRSs) depict the response of an impact variable to changes in two explanatory variables as a plotted surface. Here, IRSs of spring and winter wheat yields were constructed from a 25-member ensemble of process-based crop simulation models. Twenty-one models were calibrated by different groups using a common set of calibration data, with calibrations applied independently to the same models in three cases. The sensitivity of modelled yield to changes in temperature and precipitation was tested by systematically modifying values of 1981-2010 baseline weather data to span the range of 19 changes projected for the late 21st century at three locations in Europe.

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Common bean (Phaseolus vulgaris L.) is a leguminous in high demand for human nutrition and a very important agricultural product. Production of common bean is constrained by environmental stresses such as drought. Although conventional plant selection has been used to increase production yield and stress tolerance, drought tolerance selection based on phenotype is complicated by associated physiological, anatomical, cellular, biochemical, and molecular changes. These changes are modulated by differential gene expression. A common method to identify genes associated with phenotypes of interest is the characterization of Single Nucleotide Polymorphims (SNPs) to link them to specific functions. In this work, we selected two drought-tolerant parental lines from Mesoamerica, Pinto Villa, and Pinto Saltillo. The parental lines were used to generate a population of 282 families (F3:5) and characterized by 169 SNPs. We associated the segregation of the molecular markers in our population with phenotypes including flowering time, physiological maturity, reproductive period, plant, seed and total biomass, reuse index, seed yield, weight of 100 seeds, and harvest index in three cultivation cycles. We observed 83 SNPs with significant association (p < 0.0003 after Bonferroni correction) with our quantified phenotypes. Phenotypes most associated were days to flowering and seed biomass with 58 and 44 associated SNPs, respectively. Thirty-seven out of the 83 SNPs were annotated to a gene with a potential function related to drought tolerance or relevant molecular/biochemical functions. Some SNPs such as SNP28 and SNP128 are related to starch biosynthesis, a common osmotic protector; and SNP18 is related to proline biosynthesis, another well-known osmotic protector.

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Objectives The study sought to evaluate the ability of cardiac magnetic resonance (CMR) to monitor acute and long-term changes in pulmonary vascular resistance (PVR) noninvasively. Background PVR monitoring during the follow-up of patients with pulmonary hypertension (PH) and the response to vasodilator testing require invasive right heart catheterization. Methods An experimental study in pigs was designed to evaluate the ability of CMR to monitor: 1) an acute increase in PVR generated by acute pulmonary embolization (n = 10); 2) serial changes in PVR in chronic PH (n = 22); and 3) changes in PVR during vasodilator testing in chronic PH (n = 10). CMR studies were performed with simultaneous hemodynamic assessment using a CMR-compatible Swan-Ganz catheter. Average flow velocity in the main pulmonary artery (PA) was quantified with phase contrast imaging. Pearson correlation and mixed model analysis were used to correlate changes in PVR with changes in CMR-quantified PA velocity. Additionally, PVR was estimated from CMR data (PA velocity and right ventricular ejection fraction) using a formula previously validated. Results Changes in PA velocity strongly and inversely correlated with acute increases in PVR induced by pulmonary embolization (r = –0.92), serial PVR fluctuations in chronic PH (r = –0.89), and acute reductions during vasodilator testing (r = –0.89, p ≤ 0.01 for all). CMR-estimated PVR showed adequate agreement with invasive PVR (mean bias –1.1 Wood units,; 95% confidence interval: –5.9 to 3.7) and changes in both indices correlated strongly (r = 0.86, p < 0.01). Conclusions CMR allows for noninvasive monitoring of acute and chronic changes in PVR in PH. This capability may be valuable in the evaluation and follow-up of patients with PH.

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Ariebreen is a small (0.37 km2) valley glacier located in southern Spitsbergen. Our ground-penetrating radar surveys of the glacier show that it is less than 30 m thick on average, with a maximum thickness of 82 m, and it appears to be entirely cold. By analysing digital terrain models of the ice surface from different dates, we determine the area and volume changes during two periods, 1936-1990 and 1990-2007. The total ice volume of the glacier has decreased by 73% during the entire period 1936-2007, which is equivalent to a mean mass balance rate of -0.6190.17 m/yr w.eq. The glacier thinning rate has increased markedly between the first and second periods, from -0.5090.22 to -0.9590.17 m/yr w.eq.