Research lines in Hyperthermia at the Bioinstrumentation Laboratory of the Centre for Biomedical Technology

The Bioinstrumentation Laboratory belongs to the Centre for Biomedical Technology (CTB) of the Technical University of Madrid and its main objective is to provide the scientific community with devices and techniques for the characterization of micro and nanostructures and consequently finding their best biomedical applications. Hyperthermia (greek word for “overheating”) is defined as the phenomenon that occurs when a body is exposed to an energy generating source that can produce a rise in temperature (42-45ºC) for a given time [1]. Specifically, the aim of the hyperthermia methods used in The Bioinstrumentation Laboratory is the development of thermal therapies, some of these using different kinds of nanoparticles, to kill cancer cells and reduce the damage on healthy tissues. The optical hyperthermia is based on noble metal nanoparticles and laser irradiation. This kind of nanoparticles has an immense potential associated to the development of therapies for cancer on account of their Surface Plasmon Resonance (SPR) enhanced light scattering and absorption. In a short period of time, the absorbed light is converted into localized heat, so we can take advantage of these characteristics to heat up tumor cells in order to obtain the cellular death [2]. In this case, the laboratory has an optical hyperthermia device based on a continuous wave laser used to kill glioblastoma cell lines (1321N1) in the presence of gold nanorods (Figure 1a). The wavelength of the laser light is 808 nm because the penetration of the light in the tissue is deeper in the Near Infrared Region. The first optical hyperthermia results show that the laser irradiation produces cellular death in the experimental samples of glioblastoma cell lines using gold nanorods but is not able to decrease the cellular viability of cancer cells in samples without the suitable nanorods (Figure 1b) [3]. The generation of magnetic hyperthermia is performed through changes of the magnetic induction in magnetic nanoparticles (MNPs) that are embedded in viscous medium. The Figure 2 shows a schematic design of the AC induction hyperthermia device in magnetic fluids. The equipment has been manufactured at The Bioinstrumentation Laboratory. The first block implies two steps: the signal selection with frequency manipulation option from 9 KHz to 2MHz, and a linear output up to 1500W. The second block is where magnetic field is generated ( 5mm, 10 turns). Finally, the third block is a software control where the user can establish initial parameters, and also shows the temperature response of MNPs due to the magnetic field applied [4-8]. The Bioinstrumentation Laboratory in collaboration with the Mexican company MRI-DT have recently implemented a new research line on Nuclear Magnetic Resonance Hyperthermia, which is sustained on the patent US 7,423,429B2 owned by this company. This investigation is based on the use of clinical MRI equipment not only for diagnosis but for therapy [9]. This idea consists of two main facts: Magnetic Resonance Imaging can cause focal heating [10], and the differentiation in resonant frequency between healthy and cancer cells [11]. To produce only heating in cancer cells when the whole body is irradiated, it is necessary to determine the specific resonant frequency of the target, using the information contained in the spectra of the area of interest. Then, special RF pulse sequence is applied to produce fast excitation and relaxation mechanism that generates temperature increase of the tumor, causing cellular death or metabolism malfunction that stops cellular division

On the lateral excitation of shear modes in AlN layered resonators

In this paper we describe the fabrication and frequency characterization of different structures intended for the lateral excitation of shear modes in AlN c-axis-oriented films, which are at the same time designed to minimize the excitation of longitudinal modes. Laterally excited resonators were built on partially metallic (SiO2, W) and insulating (SiOC, Si3N4) acoustic mirrors built on silicon substrates, and on insulating mirrors (SiO2, TaOx) built on insulating glass plates. TiOx seed layers were used to stimulate the growth of highly c-axis oriented AlN films, which was confirmed by XRD and SAW measurements. Coplanar Mo electrodes of different geometries were defined on top of the AlN films to excite the shear modes. All the structures analyzed displayed a clear longitudinal mode, corresponding to an acoustic velocity of 11000 m/s, but a null or extremely weak shear response corresponding to a sound velocity of around 6350 m/s. The simulation of the frequency response based on Mason's model confirms that the shear resonance is extremely weak. The observed longitudinal modes are attributed either to the field applied between the electrodes and a conductive plane (metallic layer or Si substrate) or to the electric field parallel to the c-axis in the edges of the electrodes or in tilted grains. The low excitation of shear modes is attributed to the very low values of electric field strength parallel to the surface.

ESP in Spain: goals, achievements and prospects

This paper aims to describe the development of English for Specific Purposes (ESP) as specialised language study and research at tertiary level in Spain over the past twenty years. The year 1992 is chosen as a starting point because AELFE, the Association of Languages for Specific Purposes, was founded in Madrid at the time. As more members from other countries have joined in, this Association has served as an academic landmark for the development of ESP within the umbrella of applied linguistics. ESP has reflected the social changes, educational shifts, linguistic trends, and technological innovations involved in academic and professional contexts. The evolution of the specialised language practitioner’s scenarios and communicative situations has turned ESP into a lively and stimulating action, though not lacking in controversy, e.g., a general increase in the ESP teacher’s workload. Different lines of work and research have been followed from the inception of AELFE until the implementation of the Bologna agreement in our universities. The examination of such variables is conducted in the light of some quantitative and qualitative findings.

Large-scale testing of proficiency in English: Back to multiple choice?

The paper analyses whether that a properly designed multiple choice test can discriminate with a high level of accuracy if a student in our context has reached a B2 level according to the CEFRL.

Consulta on-line basada en corpus de construcciones con preposición en el texto técnico en inglés y su traducción al español

Basándonos en la recopilación inicial de preposiciones, locuciones preposicionales, términos con preposición dependiente y phrasal verbs utilizados en el texto técnico realizada en otros proyectos anteriores del Departamento de Lingüística Aplicada a la Ciencia y a la Tecnología, el objetivo de este trabajo es completar, organizar, actualizar y dar visibilidad a esta información inicial. Tras realizar un proceso exhaustivo de verificación, unificación, clasificación y ampliación de la información existente, en caso necesario, el listado resultante se utiliza para elaborar un glosario de términos con preposición. El objetivo final de este proyecto es que este glosario esté a disposición de los usuarios, a través de una consulta on-line, en la página del ILLLab (http://illlab.euitt.upm.es/wordpress/), dependiente del Departamento de Lingüística Aplicada a la Ciencia y a la Tecnología. Para incluir en el glosario ejemplos actualizados de textos técnicos, se ha recopilado un corpus lingüístico de textos técnicos, tomando como base diferentes números de la revista IEEE Spectrum, en su edición digital, publicados entre los años 2009 y 2012. El objetivo de esta recopilación es la de ofrecer al consultante diferentes ejemplos de uso en el texto técnico de los distintos términos con preposición que componen el glosario, de manera que pueda acceder de manera rápida y sencilla a ejemplos de uso real de los términos que está buscando, con objeto de clarificar aspectos relacionados con su uso o, en su caso, facilitar su aprendizaje. Toda esta información, tanto el listado de términos con preposición como las frases pertenecientes al corpus recopilado, se incorpora a una base de datos, alojada dentro de la misma página web del ILLLab. A través de un formulario de consulta, a disposición del usuario en dicha página, se pueden obtener todos los términos recopilados que coincidan con los criterios de búsqueda introducidos. El usuario puede realizar dos tipos de búsqueda principales: por preposición o por término completo. Además, puede elegir una búsqueda global (entre todos los términos que integran el glosario) o parcial (en una sola de las categorías en las que se han dividido los diferentes términos, de acuerdo con su función gramatical). Por último, se presentan unas estadísticas de uso de los términos recopilados dentro de los diferentes textos que integran el corpus lingüístico, de manera que pueda establecerse una relación de los que aparecen con más frecuencia en el texto técnico. ABSTRACT. Based on the initial collection of prepositions, prepositional phrases, dependent prepositions and phrasal verbs used in technical texts collected on previous projects in the Department of Applied Linguistics to Science and Technology, the aim of this project is to improve, organize, update and provide visibility to this initial information. Following a process of verification, unification, classification and extension of existing information, if necessary, a glossary of terms with preposition is built. The ultimate objective of this project is to make this glossary available to users through an online consultation in the ILLLab webpage (http://illlab.euitt.upm.es/wordpress/). The administration of tis webpage depends of the Department of Applied Linguistics in Science and Technology. A linguistic corpus of technical texts has been compiled, based on different numbers of the IEEE Spectrum magazine, in its online edition, published between the years 2009 and 2012. The aim of this collection is to provide different examples of use in the technical text for the terms included in the glossary, so that examples of the actual use of the terms consulted can be easily and quickly accessed, in order to clarify doubts regarding their meaning or translation into Spanish and facilitate learning. All this information, both the list of terms with prepositional phrases as well as the corpus developed, is incorporated in a database. Through a searching form, the ILLLab's user may obtain all the terms matching the search criteria entered. The user can perform two types of main search: by preposition or by full term. Additionally, a global search can be selected (including all terms included in the glossary) or a partial one (including only one of the glossary's categories). Finally, some statistics of use are presented according to the various texts included in the corpus, so a relation of the most frequent prepositions in the technical text can be established.

Applied genre analysis: the case of introductions in spanish teacher trainees curricular design documents

A host of studies over the years have been published on introductions to research articles across a variety of fields. However, much less attention has been paid to professional or workplace introductions as well as student written introductions. This study aims to redress this imbalance by studying the writing samples of four primary English teacher trainees’ introductions to curricular design i.e. the document candidates must present to an examination board in Spain. This genre can be considered occluded in that exemplars are private and confidential and not readily available to the aspiring candidate. Three recurrent moves were identified, namely, explaining the importance of curricular design, providing background and defining concepts. Instances of self-glorification (Bhatia 1996) were revealed. The implications of the findings can have a positive effect on students’ future writing. RESUMEN. Se han publicado varios estudios en los últimos años sobre las introducciones de los artículos de investigación en varios campos. Sin embargo, se ha prestado mucha menor atención a las introducciones en los ámbitos profesionales o las introducciones en el lugar de trabajo, así como a las introducciones escritas por estudiantes. Este estudio tiene por objeto corregir este desequilibrio mediante el análisis de cuatro introducciones redactadas por candidatos para las oposiciones públicas de profesores de inglés de primaria. Este género se puede considerar oculto puesto que las muestras de dichas introducciones no están publicadas. El análisis de estas introducciones muestra que hay tres movimientos recurrentes: una explicación de la importancia del diseño curricular, definición del contexto educativo y, por último, definición de conceptos. Hay ejemplos en este estudio empírico de auto-promoción (Bhatia 1996). Las implicaciones de los resultados pueden tener un efecto positivo en la escritura de estos estudiantes en el futuro.