22 resultados para Protein Array Analysis -- methods
em Universidad Politécnica de Madrid
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Background: Several meta-analysis methods can be used to quantitatively combine the results of a group of experiments, including the weighted mean difference, statistical vote counting, the parametric response ratio and the non-parametric response ratio. The software engineering community has focused on the weighted mean difference method. However, other meta-analysis methods have distinct strengths, such as being able to be used when variances are not reported. There are as yet no guidelines to indicate which method is best for use in each case. Aim: Compile a set of rules that SE researchers can use to ascertain which aggregation method is best for use in the synthesis phase of a systematic review. Method: Monte Carlo simulation varying the number of experiments in the meta analyses, the number of subjects that they include, their variance and effect size. We empirically calculated the reliability and statistical power in each case Results: WMD is generally reliable if the variance is low, whereas its power depends on the effect size and number of subjects per meta-analysis; the reliability of RR is generally unaffected by changes in variance, but it does require more subjects than WMD to be powerful; NPRR is the most reliable method, but it is not very powerful; SVC behaves well when the effect size is moderate, but is less reliable with other effect sizes. Detailed tables of results are annexed. Conclusions: Before undertaking statistical aggregation in software engineering, it is worthwhile checking whether there is any appreciable difference in the reliability and power of the methods. If there is, software engineers should select the method that optimizes both parameters.
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This article presents and illustrates a practical approach to the dataow analysis of constraint logic programming languages using abstract interpretation. It is rst argued that from the framework point of view it suces to propose relatively simple extensions of traditional analysis methods which have already been proved useful and practical and for exist. This is shown by proposing a simple extension of Bruynooghes traditional framework which allows it to analyze constraint logic programs. Then and using this generalized framework two abstract domains and their required abstract functions are presented the rst abstract domain approximates deniteness information and the second one freeness. Finally an approach for cobining those domains is proposed The two domains and their combination have been implemented and used in the analysis of CLP and Prolog III applications. Results from this implementation showing its performance and accuracy are also presented
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This paper presents and illustrates with an example a practical approach to the dataflow analysis of programs written in constraint logic programming (CLP) languages using abstract interpretation. It is first argued that, from the framework point of view, it sufnces to propose relatively simple extensions of traditional analysis methods which have already been proved useful and practical and for which efncient fixpoint algorithms have been developed. This is shown by proposing a simple but quite general extensión of Bruynooghe's traditional framework to the analysis of CLP programs. In this extensión constraints are viewed not as "suspended goals" but rather as new information in the store, following the traditional view of CLP. Using this approach, and as an example of its use, a complete, constraint system independent, abstract analysis is presented for approximating definiteness information. The analysis is in fact of quite general applicability. It has been implemented and used in the analysis of CLP(R) and Prolog-III applications. Results from the implementation of this analysis are also presented.
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habilidades de comprensión y resolución de problemas. Tanto es así que se puede afirmar con rotundidad que no existe el método perfecto para cada una de las etapas de desarrollo y tampoco existe el modelo de ciclo de vida perfecto: cada nuevo problema que se plantea es diferente a los anteriores en algún aspecto y esto hace que técnicas que funcionaron en proyectos anteriores fracasen en los proyectos nuevos. Por ello actualmente se realiza un planteamiento integrador que pretende utilizar en cada caso las técnicas, métodos y herramientas más acordes con las características del problema planteado al ingeniero. Bajo este punto de vista se plantean nuevos problemas. En primer lugar está la selección de enfoques de desarrollo. Si no existe el mejor enfoque, ¿cómo se hace para elegir el más adecuado de entre el conjunto de los existentes? Un segundo problema estriba en la relación entre las etapas de análisis y diseño. En este sentido existen dos grandes riesgos. Por un lado, se puede hacer un análisis del problema demasiado superficial, con lo que se produce una excesiva distancia entre el análisis y el diseño que muchas veces imposibilita el paso de uno a otro. Por otro lado, se puede optar por un análisis en términos del diseño que provoca que no cumpla su objetivo de centrarse en el problema, sino que se convierte en una primera versión de la solución, lo que se conoce como diseño preliminar. Como consecuencia de lo anterior surge el dilema del análisis, que puede plantearse como sigue: para cada problema planteado hay que elegir las técnicas más adecuadas, lo que requiere que se conozcan las características del problema. Para ello, a su vez, se debe analizar el problema, eligiendo una técnica antes de conocerlo. Si la técnica utiliza términos de diseño entonces se ha precondicionado el paradigma de solución y es posible que no sea el más adecuado para resolver el problema. En último lugar están las barreras pragmáticas que frenan la expansión del uso de métodos con base formal, dificultando su aplicación en la práctica cotidiana. Teniendo en cuenta todos los problemas planteados, se requieren métodos de análisis del problema que cumplan una serie de objetivos, el primero de los cuales es la necesidad de una base formal, con el fin de evitar la ambigüedad y permitir verificar la corrección de los modelos generados. Un segundo objetivo es la independencia de diseño: se deben utilizar términos que no tengan reflejo directo en el diseño, para que permitan centrarse en las características del problema. Además los métodos deben permitir analizar problemas de cualquier tipo: algorítmicos, de soporte a la decisión o basados en el conocimiento, entre otros. En siguiente lugar están los objetivos relacionados con aspectos pragmáticos. Por un lado deben incorporar una notación textual formal pero no matemática, de forma que se facilite su validación y comprensión por personas sin conocimientos matemáticos profundos pero al mismo tiempo sea lo suficientemente rigurosa para facilitar su verificación. Por otro lado, se requiere una notación gráfica complementaria para representar los modelos, de forma que puedan ser comprendidos y validados cómodamente por parte de los clientes y usuarios. Esta tesis doctoral presenta SETCM, un método de análisis que cumple estos objetivos. Para ello se han definido todos los elementos que forman los modelos de análisis usando una terminología independiente de paradigmas de diseño y se han formalizado dichas definiciones usando los elementos fundamentales de la teoría de conjuntos: elementos, conjuntos y relaciones entre conjuntos. Por otro lado se ha definido un lenguaje formal para representar los elementos de los modelos de análisis – evitando en lo posible el uso de notaciones matemáticas – complementado con una notación gráfica que permite representar de forma visual las partes más relevantes de los modelos. El método propuesto ha sido sometido a una intensa fase de experimentación, durante la que fue aplicado a 13 casos de estudio, todos ellos proyectos reales que han concluido en productos transferidos a entidades públicas o privadas. Durante la experimentación se ha evaluado la adecuación de SETCM para el análisis de problemas de distinto tamaño y en sistemas cuyo diseño final usaba paradigmas diferentes e incluso paradigmas mixtos. También se ha evaluado su uso por analistas con distinto nivel de experiencia – noveles, intermedios o expertos – analizando en todos los casos la curva de aprendizaje, con el fin de averiguar si es fácil de aprender su uso, independientemente de si se conoce o no alguna otra técnica de análisis. Por otro lado se ha estudiado la capacidad de ampliación de modelos generados con SETCM, para comprobar si permite abordar proyectos realizados en varias fases, en los que el análisis de una fase consista en ampliar el análisis de la fase anterior. En resumidas cuentas, se ha tratado de evaluar la capacidad de integración de SETCM en una organización como la técnica de análisis preferida para el desarrollo de software. Los resultados obtenidos tras esta experimentación han sido muy positivos, habiéndose alcanzado un alto grado de cumplimiento de todos los objetivos planteados al definir el método.---ABSTRACT---Software development is an inherently complex activity, which requires specific abilities of problem comprehension and solving. It is so difficult that it can even be said that there is no perfect method for each of the development stages and that there is no perfect life cycle model: each new problem is different to the precedent ones in some respect and the techniques that worked in other problems can fail in the new ones. Given that situation, the current trend is to integrate different methods, tools and techniques, using the best suited for each situation. This trend, however, raises some new problems. The first one is the selection of development approaches. If there is no a manifestly single best approach, how does one go about choosing an approach from the array of available options? The second problem has to do with the relationship between the analysis and design phases. This relation can lead to two major risks. On one hand, the analysis could be too shallow and far away from the design, making it very difficult to perform the transition between them. On the other hand, the analysis could be expressed using design terminology, thus becoming more a kind of preliminary design than a model of the problem to be solved. In third place there is the analysis dilemma, which can be expressed as follows. The developer has to choose the most adequate techniques for each problem, and to make this decision it is necessary to know the most relevant properties of the problem. This implies that the developer has to analyse the problem, choosing an analysis method before really knowing the problem. If the chosen technique uses design terminology then the solution paradigm has been preconditioned and it is possible that, once the problem is well known, that paradigm wouldn’t be the chosen one. The last problem consists of some pragmatic barriers that limit the applicability of formal based methods, making it difficult to use them in current practice. In order to solve these problems there is a need for analysis methods that fulfil several goals. The first one is the need of a formal base, which prevents ambiguity and allows the verification of the analysis models. The second goal is design-independence: the analysis should use a terminology different from the design, to facilitate a real comprehension of the problem under study. In third place the analysis method should allow the developer to study different kinds of problems: algorithmic, decision-support, knowledge based, etc. Next there are two goals related to pragmatic aspects. Firstly, the methods should have a non mathematical but formal textual notation. This notation will allow people without deep mathematical knowledge to understand and validate the resulting models, without losing the needed rigour for verification. Secondly, the methods should have a complementary graphical notation to make more natural the understanding and validation of the relevant parts of the analysis. This Thesis proposes such a method, called SETCM. The elements conforming the analysis models have been defined using a terminology that is independent from design paradigms. Those terms have been then formalised using the main concepts of the set theory: elements, sets and correspondences between sets. In addition, a formal language has been created, which avoids the use of mathematical notations. Finally, a graphical notation has been defined, which can visually represent the most relevant elements of the models. The proposed method has been thoroughly tested during the experimentation phase. It has been used to perform the analysis of 13 actual projects, all of them resulting in transferred products. This experimentation allowed evaluating the adequacy of SETCM for the analysis of problems of varying size, whose final design used different paradigms and even mixed ones. The use of the method by people with different levels of expertise was also evaluated, along with the corresponding learning curve, in order to assess if the method is easy to learn, independently of previous knowledge on other analysis techniques. In addition, the expandability of the analysis models was evaluated, assessing if the technique was adequate for projects organised in incremental steps, in which the analysis of one step grows from the precedent models. The final goal was to assess if SETCM can be used inside an organisation as the preferred analysis method for software development. The obtained results have been very positive, as SETCM has obtained a high degree of fulfilment of the goals stated for the method.
Linear global instability of non-orthogonal incompressible swept attachment-line boundary layer flow
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Instability of the orthogonal swept attachment line boundary layer has received attention by local1, 2 and global3–5 analysis methods over several decades, owing to the significance of this model to transition to turbulence on the surface of swept wings. However, substantially less attention has been paid to the problem of laminar flow instability in the non-orthogonal swept attachment-line boundary layer; only a local analysis framework has been employed to-date.6 The present contribution addresses this issue from a linear global (BiGlobal) instability analysis point of view in the incompressible regime. Direct numerical simulations have also been performed in order to verify the analysis results and unravel the limits of validity of the Dorrepaal basic flow7 model analyzed. Cross-validated results document the effect of the angle _ on the critical conditions identified by Hall et al.1 and show linear destabilization of the flow with decreasing AoA, up to a limit at which the assumptions of the Dorrepaal model become questionable. Finally, a simple extension of the extended G¨ortler-H¨ammerlin ODE-based polynomial model proposed by Theofilis et al.4 is presented for the non-orthogonal flow. In this model, the symmetries of the three-dimensional disturbances are broken by the non-orthogonal flow conditions. Temporal and spatial one-dimensional linear eigenvalue codes were developed, obtaining consistent results with BiGlobal stability analysis and DNS. Beyond the computational advantages presented by the ODE-based model, it allows us to understand the functional dependence of the three-dimensional disturbances in the non-orthogonal case as well as their connections with the disturbances of the orthogonal stability problem.
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Objective The neurodevelopmental–neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods Fifteen patients (age range 23–42 years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23–42 years) underwent a resting-state magnetoencephalographic evaluation and Lempel–Ziv complexity (LZC) scores were calculated. Results Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. Conclusions Results demonstrated that SCH patients failed to follow the “normal” process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. Significance Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration. Highlights ► Schizophrenic patients show higher complexity values as compared to controls. ► Schizophrenic patients showed a tendency to reduced complexity values as a function of age while controls showed the opposite tendency. ► The tendency observed in schizophrenic patients parallels the tendency observed in Alzheimer disease patients.
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El objetivo central de la presente investigación es profundizar la interpretación de los parámetros multifractales en el caso de las series de precipitación. Para ello se aborda, en primer lugar, la objetivación de la selección de la parte lineal de las curvas log-log que se encuentra en la base de los métodos de análisis fractal y multifractal; y, en segundo lugar, la generación de series artificiales de precipitación, con características similares a las reales, que permitan manipular los datos y evaluar la influencia de las modificaciones controladas de las series en los resultados de los parámetros multifractales derivados. En cuanto al problema de la selección de la parte lineal de las curvas log-log se desarrollaron dos métodos: a. Cambio de tendencia, que consiste en analizar el cambio de pendiente de las rectas ajustadas a dos subconjuntos consecutivos de los datos. b. Eliminación de casos, que analiza la mejora en el p-valor asociado al coeficiente de correlación al eliminar secuencialmente los puntos finales de la regresión. Los resultados obtenidos respecto a la regresión lineal establecen las siguientes conclusiones: - La metodología estadística de la regresión muestra la dificultad para encontrar el valor de la pendiente de tramos rectos de curvas en el procedimiento base del análisis fractal, indicando que la toma de decisión de los puntos a considerar redunda en diferencias significativas de las pendientes encontradas. - La utilización conjunta de los dos métodos propuestos ayuda a objetivar la toma de decisión sobre la parte lineal de las familias de curvas en el análisis fractal, pero su utilidad sigue dependiendo del número de datos de que se dispone y de las altas significaciones que se obtienen. En cuanto al significado empírico de los parámetros multifratales de la precipitación, se han generado 19 series de precipitación por medio de un simulador de datos diarios en cascada a partir de estimaciones anuales y mensuales, y en base a estadísticos reales de 4 estaciones meteorológicas españolas localizadas en un gradiente de NW a SE. Para todas las series generadas, se calculan los parámetros multifractales siguiendo la técnica de estimación de la DTM (Double Trace Moments - Momentos de Doble Traza) desarrollado por Lavalle et al. (1993) y se observan las modificaciones producidas. Los resultados obtenidos arrojaron las siguientes conclusiones: - La intermitencia, C1, aumenta al concentrar las precipitaciones en menos días, al hacerla más variable, o al incrementar su concentración en los días de máxima, mientras no se ve afectado por la modificación en la variabilidad del número de días de lluvia. - La multifractalidad, α, se ve incrementada con el número de días de lluvia y la variabilidad de la precipitación, tanto anual como mensual, así como también con la concentración de precipitación en el día de máxima. - La singularidad probable máxima, γs, se ve incrementada con la concentración de la lluvia en el día de precipitación máxima mensual y la variabilidad a nivel anual y mensual. - El grado no- conservativo, H, depende del número de los días de lluvia que aparezcan en la serie y secundariamente de la variabilidad general de la lluvia. - El índice de Hurst generalizado se halla muy ligado a la singularidad probable máxima. ABSTRACT The main objective of this research is to interpret the multifractal parameters in the case of precipitation series from an empirical approach. In order to do so the first proposed task was to objectify the selection of the linear part of the log-log curves that is a fundamental step of the fractal and multifractal analysis methods. A second task was to generate precipitation series, with real like features, which allow evaluating the influence of controlled series modifications on the values of the multifractal parameters estimated. Two methods are developed for selecting the linear part of the log-log curves in the fractal and multifractal analysis: A) Tendency change, which means analyzing the change in slope of the fitted lines to two consecutive subsets of data. B) Point elimination, which analyzes the improvement in the p- value associated to the coefficient of correlation when the final regression points are sequentially eliminated. The results indicate the following conclusions: - Statistical methodology of the regression shows the difficulty of finding the slope value of straight sections of curves in the base procedure of the fractal analysis, pointing that the decision on the points to be considered yield significant differences in slopes values. - The simultaneous use of the two proposed methods helps to objectify the decision about the lineal part of a family of curves in fractal analysis, but its usefulness are still depending on the number of data and the statistical significances obtained. Respect to the empiric meaning of the precipitation multifractal parameters, nineteen precipitation series were generated with a daily precipitation simulator derived from year and month estimations and considering statistics from actual data of four Spanish rain gauges located in a gradient from NW to SE. For all generated series the multifractal parameters were estimated following the technique DTM (Double Trace Moments) developed by Lavalle et al. (1993) and the variations produced considered. The results show the following conclusions: 1. The intermittency, C1, increases when precipitation is concentrating for fewer days, making it more variable, or when increasing its concentration on maximum monthly precipitation days, while it is not affected due to the modification in the variability in the number of days it rained. 2. Multifractility, α, increases with the number of rainy days and the variability of the precipitation, yearly as well as monthly, as well as with the concentration of precipitation on the maximum monthly precipitation day. 3. The maximum probable singularity, γs, increases with the concentration of rain on the day of the maximum monthly precipitation and the variability in yearly and monthly level. 4. The non-conservative degree, H’, depends on the number of rainy days that appear on the series and secondly on the general variability of the rain. 5. The general Hurst index is linked to the maximum probable singularity.
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This article describes the results of an investigation aimed at the analysis methods used in the design of the protections against scour phenomenon on offshore wind farms in transitional waters, using medium and large diameter monopile type deep foundations.
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The analysis of the interdependence between time series has become an important field of research in the last years, mainly as a result of advances in the characterization of dynamical systems from the signals they produce, the introduction of concepts such as generalized and phase synchronization and the application of information theory to time series analysis. In neurophysiology, different analytical tools stemming from these concepts have added to the ‘traditional’ set of linear methods, which includes the cross-correlation and the coherency function in the time and frequency domain, respectively, or more elaborated tools such as Granger Causality. This increase in the number of approaches to tackle the existence of functional (FC) or effective connectivity (EC) between two (or among many) neural networks, along with the mathematical complexity of the corresponding time series analysis tools, makes it desirable to arrange them into a unified-easy-to-use software package. The goal is to allow neuroscientists, neurophysiologists and researchers from related fields to easily access and make use of these analysis methods from a single integrated toolbox. Here we present HERMES (http://hermes.ctb.upm.es), a toolbox for the Matlab® environment (The Mathworks, Inc), which is designed to study functional and effective brain connectivity from neurophysiological data such as multivariate EEG and/or MEG records. It includes also visualization tools and statistical methods to address the problem of multiple comparisons. We believe that this toolbox will be very helpful to all the researchers working in the emerging field of brain connectivity analysis.
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Versatile and accurate motion capture systems, with the required properties to be integrated within both clinical and domiciliary environments, would represent a significant advance in following the progress of the patients as well as in allowing the incorporation of new data exploitation and analysis methods to enhance the functional neurorehabilitation therapeutic processes. Besides, these systems would permit the later development of new applications focused on the automatization of the therapeutic tasks in order to increase the therapist/patient ratio, thus decreasing the costs [1]. However, current motion capture systems are not still ready to work within uncontrolled environments.
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Traumatic Brain Injury -TBI- -1- is defined as an acute event that causes certain damage to areas of the brain. TBI may result in a significant impairment of an individuals physical, cognitive and psychosocial functioning. The main consequence of TBI is a dramatic change in the individuals daily life involving a profound disruption of the family, a loss of future income capacity and an increase of lifetime cost. One of the main challenges of TBI Neuroimaging is to develop robust automated image analysis methods to detect signatures of TBI, such as: hyper-intensity areas, changes in image contrast and in brain shape. The final goal of this research is to develop a method to identify the altered brain structures by automatically detecting landmarks on the image where signal changes and to provide comprehensive information to the clinician about them. These landmarks identify injured structures by co-registering the patient?s image with an atlas where landmarks have been previously detected. The research work has been initiated by identifying brain structures on healthy subjects to validate the proposed method. Later, this method will be used to identify modified structures on TBI imaging studies.
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The analysis of the interdependence between time series has become an important field of research in the last years, mainly as a result of advances in the characterization of dynamical systems from the signals they produce, the introduction of concepts such as generalized and phase synchronization and the application of information theory to time series analysis. In neurophysiology, different analytical tools stemming from these concepts have added to the ?traditional? set of linear methods, which includes the cross-correlation and the coherency function in the time and frequency domain, respectively, or more elaborated tools such as Granger Causality. This increase in the number of approaches to tackle the existence of functional (FC) or effective connectivity (EC) between two (or among many) neural networks, along with the mathematical complexity of the corresponding time series analysis tools, makes it desirable to arrange them into a unified, easy-to-use software package. The goal is to allow neuroscientists, neurophysiologists and researchers from related fields to easily access and make use of these analysis methods from a single integrated toolbox. Here we present HERMES (http://hermes.ctb.upm.es), a toolbox for the Matlab® environment (The Mathworks, Inc), which is designed to study functional and effective brain connectivity from neurophysiological data such as multivariate EEG and/or MEG records. It includes also visualization tools and statistical methods to address the problem of multiple comparisons. We believe that this toolbox will be very helpful to all the researchers working in the emerging field of brain connectivity analysis.
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Las piezas pretensadas de hormigón presentan zonas muy solicitadas correspondientes a la zona de transferencia. En muchos casos se ha detectado figuración en tales zonas cuyo origen está ligado a la transferencia de la fuerza de pretensado, pudiendo llegar a causar el rechazo de la pieza. En el caso de las piezas prefabricadas con armaduras pretesas adherentes, no siempre es posible disponer armado transversal para controlar esta fisuración, ya sea por el proceso constructivo, ya sea por disponer en general de secciones transversales muy optimizadas. Recientemente se desarrolló una nueva tipología de piezas de hormigón prefabricado para forjados unidireccionales pretensadas con armadura activa pretesa y sin armadura transversal. La tipología se asimila a una sección en PI invertida, con alas de gran envergadura en comparación con el ancho de nervio, y armadura activa distribuida en las alas. Este diseño parece propenso a la aparición de fisuración en el momento de la transferencia del pretensado. Así, se han producido fallos de carácter frágil: colapso de piezas ya colocadas en obra, separándose la losa inferior de los nervios y cayendo sobre el piso. Las herramientas de análisis usuales han resultado inútiles al aplicarse a la investigación de esta patología. Para afrontar el estudio de los problemas detectados en la tipología, se ha analizado el fenómeno de las tensiones de tracción en la zona de transferencia, usualmente denominadas exfoliación y estallido, así como los métodos de análisis aplicables a elementos pretesos sin armadura transversal. En algunas ocasiones se trata del resultado de trabajos desarrollados para piezas postesadas, o para calcular cuantías de armadura transversal, adaptados a posteriori. También existen métodos desarrollados específicamente para piezas pretesas sin armadura transversal. Junto a los factores considerados en los métodos existentes se han localizado otros, no tenidos en cuenta habitualmente, pero que pueden ser determinantes en piezas no convencionales, como son: la existencia de pretensado superior e inferior, la falta de simetría de la sección transversal, el ancho variable de las piezas, una relación entre el ancho del ala y el espesor de los nervios elevada, la distribución transversal del pretensado en relación al ancho variable. Además, la mayoría de los métodos se han basado en simplificaciones bidimensionales. Para tener en cuenta la influencia de estos factores, se han modelizado piezas en las que varían tanto la geometría de la sección transversal y la cuantía de pretensado, como la ley de adherencia o la distribución de armadura activa en la sección. Estos modelos se han analizado mediante el método de elementos finitos, efectuándose u análisis elástico lineal tridimensional. En general, los métodos existentes no han predicho adecuadamente las tensiones obtenidas mediante elementos finitos. Sobre los resultados obtenidos por elementos finitos se ha desarrollado un ajuste experimental, que presentan un alto grado de correlación y de significación, así como una reducida dispersión y error relativo. En consecuencia, se propone un método de obtención de la tensión máxima de exfoliación, consistente en varias ecuaciones, que tienen en cuenta las peculiaridades de la configuración de las piezas citadas y permiten considerar cualquier ley de adherencia, manteniendo la coherencia con la longitud de transmisión. Las ecuaciones se emplean para la obtención de la tensión máxima de exfoliación en piezas de la tipología estudiada cuya armadura activa se sitúe fuera del núcleo central de la sección transversal. Respecto al estallido, se propone una modificación de los métodos existentes que, comparado con los resultados del análisis por elementos finitos, mejora el valor medio y la dispersión a valores admisibles y del lado de la seguridad. El método considera la geometría de la sección y la distribución del pretensado en la losa inferior. Finalmente, se ofrecen estrategias de diseño para piezas de la tipología o semejantes. End zones of prestressed concrete members are highly stressed. Cracking have often appeared at end zone, and its beginning is related to prestress release. Some members become rejected because of these cracks. Sometimes it is not possible having transverse reinforcement in order to control cracking, when referring to pretensioned precast members. The reason may be the construction process or highly optimized crosssections. A new typology of precast concrete members designed for one-way composite floors was recently developed. The members, without transverse reinforcement, are prestressed with pretensioned wires or strands. This typology is similar to an inverted TT slab, with a large flange related to the web thickness and prestressing reinforcement spread across the flange. This design is highly susceptible to appear cracking at prestress release. Therefore, brittle failures have been reported: fail of slabs laid in place on a construction site, resulting in the separation of the flange from the webs,, and the subsequent fall on the lower floor. Usual analytical methods have been useless to study the failure. End zone tensile stresses have been analysed to study the detected typology problems. These tensile stresses are usually called spalling and bursting (also called splitting in the U.S.). Analysis methods applicable to pretensioned members without transverse reinforcement have been analysed too. Some methods were originally developed for postensioned concrete or for obtaining the amount of transverse reinforcement. In addition, there are methods developed specifically for pretensioned members without transverse reinforcement. Some factors, frequently ignored, have been found, such as lower and upper prestress, lack of symmetry in the cross section, variable width, a high ratio between flange width and web thickness or prestressing reinforcement location related to variable width. They can play a decisive role in non-conventional members. In addition, most methods are based on 2D simplifications. Finite Element modelling has been conducted in order to consider the influence of these factors. A linear 3D approach has been used. The modelled members vary according to cross section geometry, bond behaviour, or prestressing reinforcement location. In general, the obtained tensile stresses don’t agree with existing methods. An experimental adjustment has been conducted on the obtained results, with a high correlation ratio and significance level as well as a low dispersion and relative error. Therefore, a method to obtain the maximum spalling stress is proposed. The proposal consists on some equations that consider the special features of the typology and bond behaviour. Consistency between transmission length and bond behaviour is considered too. The equations are used to calculate maximum spalling stress for the studied typology members whose prestressing reinforcement is located out of the core of the cross section. In relation to bursting, a modification of existing methods is proposed. Compared to finite element results, the proposal improves mean value and dispersion, whose ranges are considered acceptable and secure. The method takes into account cross section geometry and location of prestressing reinforcement across the lower flange. Finally, strategies to design members of this typology or similar are proposed.
Resumo:
A 2D computer simulation method of random packings is applied to sets of particles generated by a self-similar uniparametric model for particle size distributions (PSDs) in granular media. The parameter p which controls the model is the proportion of mass of particles corresponding to the left half of the normalized size interval [0,1]. First the influence on the total porosity of the parameter p is analyzed and interpreted. It is shown that such parameter, and the fractal exponent of the associated power scaling, are efficient packing parameters, but this last one is not in the way predicted in a former published work addressing an analogous research in artificial granular materials. The total porosity reaches the minimum value for p = 0.6. Limited information on the pore size distribution is obtained from the packing simulations and by means of morphological analysis methods. Results show that the range of pore sizes increases for decreasing values of p showing also different shape in the volume pore size distribution. Further research including simulations with a greater number of particles and image resolution are required to obtain finer results on the hierarchical structure of pore space.
Resumo:
Arch bridge structural solution has been known for centuries, in fact the simple nature of arch that require low tension and shear strength was an advantage as the simple materials like stone and brick were the only option back in ancient centuries. By the pass of time especially after industrial revolution, the new materials were adopted in construction of arch bridges to reach longer spans. Nowadays one long span arch bridge is made of steel, concrete or combination of these two as "CFST", as the result of using these high strength materials, very long spans can be achieved. The current record for longest arch belongs to Chaotianmen bridge over Yangtze river in China with 552 meters span made of steel and the longest reinforced concrete type is Wanxian bridge which also cross the Yangtze river through a 420 meters span. Today the designer is no longer limited by span length as long as arch bridge is the most applicable solution among other approaches, i.e. cable stayed and suspended bridges are more reasonable if very long span is desired. Like any super structure, the economical and architectural aspects in construction of a bridge is extremely important, in other words, as a narrower bridge has better appearance, it also require smaller volume of material which make the design more economical. Design of such bridge, beside the high strength materials, requires precise structural analysis approaches capable of integrating the combination of material behaviour and complex geometry of structure and various types of loads which may be applied to bridge during its service life. Depend on the design strategy, analysis may only evaluates the linear elastic behaviour of structure or consider the nonlinear properties as well. Although most of structures in the past were designed to act in their elastic range, the rapid increase in computational capacity allow us to consider different sources of nonlinearities in order to achieve a more realistic evaluations where the dynamic behaviour of bridge is important especially in seismic zones where large movements may occur or structure experience P - _ effect during the earthquake. The above mentioned type of analysis is computationally expensive and very time consuming. In recent years, several methods were proposed in order to resolve this problem. Discussion of recent developments on these methods and their application on long span concrete arch bridges is the main goal of this research. Accordingly available long span concrete arch bridges have been studied to gather the critical information about their geometrical aspects and properties of their materials. Based on concluded information, several concrete arch bridges were designed for further studies. The main span of these bridges range from 100 to 400 meters. The Structural analysis methods implemented in in this study are as following: Elastic Analysis: Direct Response History Analysis (DRHA): This method solves the direct equation of motion over time history of applied acceleration or imposed load in linear elastic range. Modal Response History Analysis (MRHA): Similar to DRHA, this method is also based on time history, but the equation of motion is simplified to single degree of freedom system and calculates the response of each mode independently. Performing this analysis require less time than DRHA. Modal Response Spectrum Analysis (MRSA): As it is obvious from its name, this method calculates the peak response of structure for each mode and combine them using modal combination rules based on the introduced spectra of ground motion. This method is expected to be fastest among Elastic analysis. Inelastic Analysis: Nonlinear Response History Analysis (NL-RHA): The most accurate strategy to address significant nonlinearities in structural dynamics is undoubtedly the nonlinear response history analysis which is similar to DRHA but extended to inelastic range by updating the stiffness matrix for every iteration. This onerous task, clearly increase the computational cost especially for unsymmetrical buildings that requires to be analyzed in a full 3D model for taking the torsional effects in to consideration. Modal Pushover Analysis (MPA): The Modal Pushover Analysis is basically the MRHA but extended to inelastic stage. After all, the MRHA cannot solve the system of dynamics because the resisting force fs(u; u_ ) is unknown for inelastic stage. The solution of MPA for this obstacle is using the previously recorded fs to evaluate system of dynamics. Extended Modal Pushover Analysis (EMPA): Expanded Modal pushover is a one of very recent proposed methods which evaluates response of structure under multi-directional excitation using the modal pushover analysis strategy. In one specific mode,the original pushover neglect the contribution of the directions different than characteristic one, this is reasonable in regular symmetric building but a structure with complex shape like long span arch bridges may go through strong modal coupling. This method intend to consider modal coupling while it take same time of computation as MPA. Coupled Nonlinear Static Pushover Analysis (CNSP): The EMPA includes the contribution of non-characteristic direction to the formal MPA procedure. However the static pushovers in EMPA are performed individually for every mode, accordingly the resulted values from different modes can be combined but this is only valid in elastic phase; as soon as any element in structure starts yielding the neutral axis of that section is no longer fixed for both response during the earthquake, meaning the longitudinal deflection unavoidably affect the transverse one or vice versa. To overcome this drawback, the CNSP suggests executing pushover analysis for governing modes of each direction at the same time. This strategy is estimated to be more accurate than MPA and EMPA, moreover the calculation time is reduced because only one pushover analysis is required. Regardless of the strategy, the accuracy of structural analysis is highly dependent on modelling and numerical integration approaches used in evaluation of each method. Therefore the widely used Finite Element Method is implemented in process of all analysis performed in this research. In order to address the study, chapter 2, starts with gathered information about constructed long span arch bridges, this chapter continuous with geometrical and material definition of new models. Chapter 3 provides the detailed information about structural analysis strategies; furthermore the step by step description of procedure of all methods is available in Appendix A. The document ends with the description of results and conclusion of chapter 4.